gpt:Gene Product(s): Difference between revisions

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Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
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complete
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GO:0032263
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GMP salvage
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PMID:820683
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IMP: Inferred from Mutant Phenotype
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P
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Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete  
complete  
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InterPro:IPR002375<br />SP_KW:KW-0808
InterPro:IPR002375<br />SP_KW:KW-0808
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F
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Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
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complete
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GO:0016757
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transferase activity, transferring glycosyl groups
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GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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SP_KW:KW-0328
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F
F
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GO:0016757
GO:0032263
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transferase activity, transferring glycosyl groups
GMP salvage
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GO_REF:0000004
PMID:820683
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IEA: Inferred from Electronic Annotation
IMP: Inferred from Mutant Phenotype
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SP_KW:KW-0328
 
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F
P
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Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>

Revision as of 01:53, 12 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Gpt

Synonyms

guanine-hypoxanthine phosphoribosyltransferase[1], B0238[2][1], Gxu[2][1], GlyD[2][1], Gpt[2][1]

Product description

Gpt[2][3];

Component of GPT-CPLX[2]

Guanine-xanthine phosphoribosyltransferase phosphotransferase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0000310

xanthine phosphoribosyltransferase activity

PMID:6305942[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0004422

hypoxanthine phosphoribosyltransferase activity

PMID:6305942[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [7]

complete

GO:0005515

protein binding

PMID:16606699[8]

IPI: Inferred from Physical Interaction

UniProtKB:P0A901

F

Seeded from EcoCyc [7]

complete

GO:0032264

IMP salvage

PMID:6305942[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0032265

XMP salvage

PMID:820683[9]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0000287

magnesium ion binding

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460
HAMAP:MF_01903

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0000310

xanthine phosphoribosyltransferase activity

GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

EC:2.4.2.22
HAMAP:MF_01903

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0006166

purine ribonucleoside salvage

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0660
HAMAP:MF_01903

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0009116

nucleoside metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000836

P

Seeded from EcoCyc [7]

complete

GO:0016740

transferase activity

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002375
SP_KW:KW-0808

F

Seeded from EcoCyc [7]

complete

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0328

F

Seeded from EcoCyc [7]

complete

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005829

cytosol

PMID:16858726[10]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [7]

complete

GO:0005886

plasma membrane

GO_REF:0000020
GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

HAMAP:MF_01903
SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [7]

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc [7]

complete

GO:0015949

nucleobase, nucleoside and nucleotide interconversion

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0032263

GMP salvage

PMID:820683[9]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [7]

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of GPT-CPLX

could be indirect

Protein

blc

PMID:16606699[8]

Experiment(s):EBI-1135993

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes

cytoplasm

From EcoCyc[3]

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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSEKYIVTWD MLQIHARKLA SRLMPSEQWK GIIAVSRGGL VPGALLAREL GIRHVDTVCI
SSYDHDNQRE LKVLKRAEGD GEGFIVIDDL VDTGGTAVAI REMYPKAHFV TIFAKPAGRP
LVDDYVVDIP QDTWIEQPWD MGVVFVPPIS GR
Mol. Wt

16.97 kDa (calc) [2]

pI

5.85[2]

Extinction coefficient

27960 - 28085 (calc based on 4 Y, 4 W, and 1 C residues)

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Domains/Motifs/Modification Sites See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes
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Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>gpt 562</beststructure>

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:GPT-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A9M5

PFAM (EcoliWiki Page)

PFAM:PF00156

RefSeq (EcoliWiki Page)

RefSeq:NP_414773

ModBase (EcoliWiki Page)

ModBase:P0A9M5

PDB (EcoliWiki Page)

PDB:1A95


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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Liu, SW & Milman, G (1983) Purification and characterization of Escherichia coli guanine-xanthine phosphoribosyltransferase produced by a high efficiency expression plasmid utilizing a lambda PL promoter and CI857 temperature-sensitive repressor. J. Biol. Chem. 258 7469-75 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 Holden, JA et al. (1976) Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase. J. Bacteriol. 126 1141-8 PubMed
  10. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed


Categories

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