dnaA:Quickview: Difference between revisions

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Adding EcoGene Comments
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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[dnaA:Gene|''dnaA]]'' (synonyms: ''ECK3694, b3702, JW3679'')<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[dnaA:Gene_Product(s)|DnaA product]]<ref name='LIB:Riley_2006'/>: chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator product, B3702 product, DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator product
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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DnaA transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
!align=left {{table_heading_style}} |Product Synonyms(s)
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:dnaAN-recF|dnaAN-recF]]<ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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Revision as of 20:26, 4 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name
Gene Synonym(s)
Product Desc.
Product Synonyms(s)
Knock-Out Phenotype
Regulation/Expression
Regulation/Activity
edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. Acidic phospholipids release bound ADP, reactivating DnaA by allowing ATP to rebind. Null mutations in seqA, yccV or rpoN suppress dna46(Ts). Increases in DnaA levels reduce Fis oriC primary binding thus allowing DnaA to bind, this may play a role in the dynamics of prereplication complexes. Collapsed replication forks (primarily within 10 map units of oriC) are a result of the level of initiation induced by elevated dnaA expression. Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008).[1]



References

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  1. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.