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===Notes===
===Notes===
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PutA is a multifunctional membrane-associated flavoprotein involved in proline catabolism: the central proline dehydrogenese domain feeds its product to the C-terminal Delta(1)-pyrroline-5-carboxylate dehydrogenese domain, to produce glutamate. The N-terminal 90 residue domain is the DNA-binding repressor domain. A divergon is a regulon comprised of two adjacent divergent operons or genes. Binds TrxA (Kumar, 2004).<ref name='LIB:EcoGene'/>





Revision as of 00:27, 3 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

putA (synonyms: ECK1005, b1014, JW0999, poaA, putC, proline utilization A)[1][2]

Product(s)

PutA product[1]: fused DNA-binding transcriptional regulator product, proline dehydrogenase product, pyrroline-5-carboxylate dehydrogenase product, B1014 product, PutC product, PoaA product

Description

PutA bifunctional enzyme and transcriptional regulator[2] PutA transcriptional repressor, Proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase[3]

Component of PUTA-CPLX[2]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): putA[2]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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PutA is a multifunctional membrane-associated flavoprotein involved in proline catabolism: the central proline dehydrogenese domain feeds its product to the C-terminal Delta(1)-pyrroline-5-carboxylate dehydrogenese domain, to produce glutamate. The N-terminal 90 residue domain is the DNA-binding repressor domain. A divergon is a regulon comprised of two adjacent divergent operons or genes. Binds TrxA (Kumar, 2004).[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.