cysB:Gene Product(s): Difference between revisions

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Table edited by Gwen via TableEdit
Table edited by Gwen via TableEdit
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[[PMID:6792186]]<ref name=PMID:6792186/>
[[PMID:6792186]]<ref name=PMID:6792186/>
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IDA: Inferred from Direct Assay
IMP: Inferred from Mutant Phenotype
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Revision as of 17:51, 18 July 2008

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

CysB product

Synonyms

DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding product[1], B1275 product[2][1], CysB product[2][1], positive transcriptional regulator for cysteine regulon product[2][1]

Product description

CysB[2][3];

Component of ; CysB transcriptional dual regulator[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0006350

transcription

P

Seeded from EcoCyc 11.1[3].

required fields missing

NOT

GO:0019344

cysteine biosynthetic process

P

Seeded from EcoCyc 11.1[3].

CysB is a regulator of genes involved in the cystein biosynthetic process

required field missing

GO:0016564

transcription repressor activity

PMID:10506196[4]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 11.1[3].

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016563

transcription activator activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016564

transcription repressor activity

PMID:6792186[5]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc 11.1[3].

complete

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Interactions

Partner Type Partner Notes

Protein

Subunits of CysB transcriptional dual regulator

could be indirect

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Notes

Localization

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc

MKLQQLRYIV EVVNHNLNVS STAEGLYTSQ PGISKQVRML EDELGIQIFS RSGKHLTQVT
PAGQEIIRIA REVLSKVDAI KSVAGEHTWP DKGSLYIATT HTQARYALPN VIKGFIERYP
RVSLHMHQGS PTQIADAVSK GNADFAIATE ALHLYEDLVM LPCYHWNRAI VVTPDHPLAG
KKAITIEELA QYPLVTYTFG FTGRSELDTA FNRAGLTPRI VFTATDADVI KTYVRLGLGV
GVIASMAVDP VADPDLVRVD AHDIFSHSTT KIGFRRSTFL RSYMYDFIQR FAPHLTRDVV
DAAVALRSNE EIEVMFKDIK LPEK
Mol. Wt

36.15 kDa (calc) [2]

pI

7.25[2]

Extinction coefficient

28880 - 29005 (calc based on 12 Y, 2 W, and 1 C residues)

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Domains/Motifs/Modification Sites

Type Residues Description Notes
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Structure

Structure Type Organism Accession Residues covered Notes

X-RAY DIFFRACTION

Klebsiella aerogenes

1AL3 COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES

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Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:PD00232

SwissModel (EcoliWiki Page)

SwissModel:P0A9F3

UniProt (EcoliWiki Page)

UniProt:P0A9F3

PFAM (EcoliWiki Page)

PFAM:PF00126

RefSeq (EcoliWiki Page)

RefSeq:NP_415791

ModBase (EcoliWiki Page)

ModBase:P0A9F3

PDB (EcoliWiki Page)

PDB:1AL3

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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ van Der Ploeg, JR et al. (1999) The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl. J. Biol. Chem. 274 29358-65 PubMed
  5. ↑ Jagura-Burdzy, G & Hulanicka, D (1981) Use of gene fusions to study expression of cysB, the regulatory gene of the cysteine regulon. J. Bacteriol. 147 744-51 PubMed


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