Phage lambda cI:Gene Product(s)

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Gene

Gene Product(s)

Expression

Evolution

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Nomenclature

Function

Interactions

Localization

Sequence

Domains

Structure

Resources

Accessions

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References

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	cI
Synonyms	cI, lambdap88
Product description	repressor
EC number (for enzymes)
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Function

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Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Localization

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Compartment	Description	Evidence	Source	Notes
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Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	MSTKKKPLTQ EQLEDARRLK AIYEKKKNEL GLSQESVADK MGMGQSGVGA LFNGINALNA YNAALLAKIL KVSVEEFSPS IAREIYEMYE AVSMQPSLRS EYEYPVFSHV QAGMFSPELR TFTKGDAERW VSTTKKASDS AFWLEVEGNS MTAPTGSKPS FPDGMLILVD PEQAVEPGDF CIARLGGDEF TFKKLIRDSG QVFLQPLNPQ YPMIPCNESC SVVGKVIASQ WPEETFG
Length
Mol. Wt
pI
Extinction coefficient
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki. Type Residues Description Notes References Domain 19 - 77 HTH cro/C1-type UniProt:P03034 edit table

<motif_map/>

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki. Structures <beststructure> gene=Phage_lambda_cI taxon=10710 </beststructure> Models View models at: PSI-PRED Genomes TO Protein (GTOP) edit table

Structure figures

See Help:Jmol in EcoliWiki full length lambda repressor bound to operator DNA <jmol> <jmolApplet> <color>white</color> <uploadedFileContents >3BDN.pdb</uploadedFileContents> <script> wireframe off; spacefill off; trace off; reset;center {11.954998 19.6415 35.014}; rotate z 95.96; rotate y 86.35; rotate z 117.3; cartoon; select protein; color chain; </script> </jmolApplet> </jmol> <jmol> <jmolCheckbox > <scriptWhenChecked > rotate on; </scriptWhenChecked > <scriptWhenUnchecked > rotate off; </scriptWhenUnchecked > <checked>false</checked> <text>rotate</text> </jmolCheckbox > <jmolButton><script>reset; reset;center {11.954998 19.6415 35.014}; rotate z 95.96; rotate y 86.35; rotate z 117.3; cartoon; select protein; color chain; </script><text>reset</text></jmolButton> </jmol>

Notes

Lambda repressor consists of an N-terminal DNA binding domain and a C-terminal oligomerization domain, connected by a flexible linker. The N-terminal domain in isolation dimerizes weakly through helix 5-helix 5 contacts. The C-terminal domain is required for dimerization and DNA binding at normal in vivo expression levels. Induction of phage lambda by the SOS response involves autoproteolysis at a specific site in the linker by the C-domain.

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Genbank (EcoliWiki Page)	Genbank:NP_040628.1
UniProt (EcoliWiki Page)	UniProt:P03034
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Links

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Name	URL	Comments
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References

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Categories

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