umuD:Expression: Difference between revisions
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===Notes=== | ===Notes=== | ||
UmuD<sub>2</sub> and the UmuD' subunit of the UmuDD' heterodimer are degraded by ClpXP <ref name='PMID:14595014'/> <ref name='PMID:11013227'/><br /> | |||
UmuD<sub>2</sub> is degraded by Lon protease <ref name='PMID:9869642'/> | |||
==Experimental== | ==Experimental== | ||
Revision as of 21:09, 21 February 2011
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Overview | Transcription | Translation | Turnover | Experimental | Links | References | Suggestions |
Overview
This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Cellular Levels
| Molecule | Organism or Strain | Value | Units | Experimental Conditions | Assay used | Notes | Reference(s) |
|---|---|---|---|---|---|---|---|
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Notes
Transcription and Transcriptional Regulation
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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.
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Notes
LexA-regulated[1]
Translation and Regulation of Translation
<gbrowseImage> name=NC_000913:1229970..1230010 source=ecoli type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.
Notes
This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Turnover and Regulation of Turnover
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Notes
UmuD2 and the UmuD' subunit of the UmuDD' heterodimer are degraded by ClpXP [2] [3]
UmuD2 is degraded by Lon protease [4]
Experimental
Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.
| Allele Name | Mutation | Phenotype | Reference |
|---|---|---|---|
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Expression Studies
See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.
| Type | Reference | Notes |
|---|---|---|
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microarray |
NCBI GEO profiles for umuD | |
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microarray |
Summary of data for umuD from multiple microarray studies | |
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Expression Resources
See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.
| Resource Name | Resource Type | Description | Source | Notes |
|---|---|---|---|---|
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GFP Fusion |
Intergenic region (1229552..1230069) fused to gfpmut2. |
GFP fusion described in Zaslaver, et al. | ||
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Notes
Accessions Related to umuD Expression
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ Caramel, A & Schnetz, K (2000) Antagonistic control of the Escherichia coli bgl promoter by FIS and CAP in vitro. Mol. Microbiol. 36 85-92 PubMed
- ↑ Neher, SB et al. (2003) Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease. Proc. Natl. Acad. Sci. U.S.A. 100 13219-24 PubMed
- ↑ Gonzalez, M et al. (2000) Subunit-specific degradation of the UmuD/D' heterodimer by the ClpXP protease: the role of trans recognition in UmuD' stability. EMBO J. 19 5251-8 PubMed
- ↑ Gonzalez, M et al. (1998) Lon-mediated proteolysis of the Escherichia coli UmuD mutagenesis protein: in vitro degradation and identification of residues required for proteolysis. Genes Dev. 12 3889-99 PubMed
- ↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed
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