DNA Mismatch Repair: Difference between revisions
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==Components== | ==Components== | ||
*[[mutS:Gene_Product(s)|MutS]]- Mismatch Recognition and Specificity | *[[mutS:Gene_Product(s)|MutS]]<ref name='PMID:1542666'/>- Mismatch Recognition and Specificity | ||
*[[mutH:Gene_Product(s)|MutH]] | *[[mutH:Gene_Product(s)|MutH]] | ||
*[[mutL:Gene_Product(s)|MutL]]<ref name='PMID:10734142'/> | *[[mutL:Gene_Product(s)|MutL]]<ref name='PMID:10734142'/> | ||
Revision as of 20:42, 30 August 2010
General Description
"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
Corrects mismatched and unpaired bases arising from:
- Replication Errors
- Physical Damage to Bases
- Homologous Recombination
Review Articles[1]
Components
Function
Regulation
Cell Biology
1. Recognition of a Mismatch[4][5]
- MutS binds DNA non-specifically and bends it in search of a mismatch
- MutS undergoes a conformation change when bound to a mismatched duplex to form an initial recognition complex (DNA is kinked)
- MutS undergoes a further conformation change to a final recognition complex (DNA is unbent)
Experimental Resources
Comparison with other Organisms
Notes
Related GO Terms
References
- ↑ Modrich, P & Lahue, R (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65 101-33 PubMed
- ↑ Parker, BO & Marinus, MG (1992) Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 89 1730-4 PubMed
- ↑ Spampinato, C & Modrich, P (2000) The MutL ATPase is required for mismatch repair. J. Biol. Chem. 275 9863-9 PubMed
- ↑ Wang, H et al. (2003) DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc. Natl. Acad. Sci. U.S.A. 100 14822-7 PubMed
- ↑ Smith, J & Modrich, P (1996) Mutation detection with MutH, MutL, and MutS mismatch repair proteins. Proc. Natl. Acad. Sci. U.S.A. 93 4374-9 PubMed