msbA:Gene Product(s): Difference between revisions
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MsbA | MsbA | ||
fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | |||
ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | |||
Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/> | |||
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!align=left {{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
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!align=left {{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
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!align=left {{table heading style}} |EC number (for enzymes) | !align=left {{table heading style}} |EC number (for enzymes) | ||
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GO:0005319 | |||
lipid transporter activity | |||
GOA:hamap<br />GO_REF:0000020 | |||
IEA: Inferred from Electronic Annotation | |||
HAMAP:MF_01703 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005524 | |||
ATP binding | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR001140 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005524 | |||
ATP binding | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR003439 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005524 | |||
ATP binding | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR011527 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005524 | |||
ATP binding | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR011917 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005524 | |||
ATP binding | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR017871 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005524 | |||
ATP binding | |||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
IEA: Inferred from Electronic Annotation | |||
SP_KW:KW-0067 | |||
F | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005886 | |||
plasma membrane | |||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
IEA: Inferred from Electronic Annotation | |||
SP_KW:KW-0997 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005886 | |||
plasma membrane | |||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
IEA: Inferred from Electronic Annotation | |||
SP_KW:KW-1003 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0006869 | |||
lipid transport | |||
GOA:hamap<br />GO_REF:0000020 | |||
IEA: Inferred from Electronic Annotation | |||
HAMAP:MF_01703 | |||
P | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0006869 | |||
lipid transport | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR011917 | |||
P | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0006869 | |||
lipid transport | |||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
IEA: Inferred from Electronic Annotation | |||
SP_KW:KW-0445 | |||
P | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0016020 | |||
membrane | |||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
IEA: Inferred from Electronic Annotation | |||
SP_KW:KW-0472 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0016020 | |||
membrane | |||
PMID:16858726 | |||
IDA: Inferred from Direct Assay | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0016021 | |||
integral to membrane | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR001140 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0016021 | |||
integral to membrane | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR011527 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0016021 | |||
integral to membrane | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR011917 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0005515 | |||
protein binding | |||
PMID:18344567 | |||
IDA: Inferred from Direct Assay | |||
C | |||
complete | |||
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|- | |- | ||
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GO:0016021 | |||
integral to membrane | |||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
IEA: Inferred from Electronic Annotation | |||
SP_KW:KW-0812 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0034040 | |||
lipid-transporting ATPase activity | |||
PMID:18344567 | |||
IDA: Inferred from Direct Assay | |||
F | |||
complete | |||
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GO:0016021 | |||
integral to membrane | |||
GO_REF:0000023 | |||
IEA: Inferred from Electronic Annotation | |||
SP_SL:SL-9909 | |||
C | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0008289 | |||
lipid binding | |||
PMID:18344567 | |||
IDA: Inferred from Direct Assay | |||
F | |||
complete | |||
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|- | |- | ||
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GO:0055085 | |||
transmembrane transport | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR001140 | |||
P | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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GO:0008144 | |||
drug binding | |||
PMID:18344567 | |||
IDA: Inferred from Direct Assay | |||
F | |||
complete | |||
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|- | |- | ||
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GO:0055085 | |||
transmembrane transport | |||
GOA:interpro<br />GO_REF:0000002 | |||
IEA: Inferred from Electronic Annotation | |||
InterPro:IPR011527 | |||
P | |||
Seeded from [[EcoCyc]] (v14.0) | |||
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plasma membrane | plasma membrane | ||
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains | |||
Daley et al. (2005) <ref name=PMID:15919996/> | |||
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LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS | LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS | ||
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ</pre> | TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ</pre> | ||
582 | |||
64.462 kDa | |||
8.8 (calculated) | |||
46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues) | |||
|- | |- | ||
!align=left {{table heading style}} |Length | !align=left {{table heading style}} |Length | ||
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|- | |- | ||
!align=left {{table heading style}} |Mol. Wt | !align=left {{table heading style}} |Mol. Wt | ||
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|- | |- | ||
!align=left {{table heading style}} |pI | !align=left {{table heading style}} |pI | ||
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|- | |- | ||
!align=left {{table heading style}} |Extinction coefficient | !align=left {{table heading style}} |Extinction coefficient | ||
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|- class="tableEdit_footer" | |- class="tableEdit_footer" | ||
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taxon=562,83333 | taxon=562,83333 | ||
</beststructure> | </beststructure> | ||
View models at: | View models at: | ||
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict] | * [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict] | ||
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* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS) | * [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS) | ||
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP) | * [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP) | ||
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!align=left {{table heading style}} |Models | |||
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|- class="tableEdit_footer" | |- class="tableEdit_footer" | ||
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]]) | [http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]]) | ||
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10613-MONOMER EcoCyc:EG10613-MONOMER] | |||
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | [http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | ||
[[uniprot:P60752|UniProt:P60752]] | |||
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]]) | [http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]]) | ||
[http://pfam.sanger.ac.uk/family?acc=PF00664 PFAM:PF00664] | |||
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]]) | [http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]]) | ||
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415434 RefSeq:NP_415434] | |||
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Revision as of 23:06, 18 June 2010
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
MsbA fused lipid transporter subunits of ABC superfamily: membrane component[1], ATP-binding component[1], B0914[2][1], MsbA[2][1] ATP-binding transport protein[2][3] Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase[4] |
|---|---|
| Synonyms | |
| Product description | |
| EC number (for enzymes) |
|
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005319
lipid transporter activity
GOA:hamap |
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| GO:0005524
ATP binding
GOA:interpro |
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| GO:0005524
ATP binding
GOA:interpro |
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| GO:0005524
ATP binding
GOA:interpro |
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| GO:0005524
ATP binding
GOA:interpro |
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| GO:0005524
ATP binding
GOA:interpro |
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| GO:0005524
ATP binding
GOA:spkw |
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| GO:0005886
plasma membrane
GOA:spkw |
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| GO:0005886
plasma membrane
GOA:spkw |
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| GO:0006869
lipid transport
GOA:hamap |
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| GO:0006869
lipid transport
GOA:interpro |
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| GO:0006869
lipid transport
GOA:spkw |
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| GO:0016020
membrane
GOA:spkw |
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| GO:0016020
membrane PMID:16858726[5] IDA: Inferred from Direct Assay C Seeded from EcoCyc (v14.0) |
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| GO:0016021
integral to membrane
GOA:interpro |
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| GO:0016021
integral to membrane
GOA:interpro |
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| GO:0016021
integral to membrane
GOA:interpro |
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| GO:0005515
protein binding PMID:18344567[6] IDA: Inferred from Direct Assay C complete |
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| GO:0016021
integral to membrane
GOA:spkw |
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| GO:0034040
lipid-transporting ATPase activity PMID:18344567[6] IDA: Inferred from Direct Assay F complete |
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| GO:0016021
integral to membrane GO_REF:0000023 IEA: Inferred from Electronic Annotation SP_SL:SL-9909 C Seeded from EcoCyc (v14.0) |
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| GO:0008289
lipid binding PMID:18344567[6] IDA: Inferred from Direct Assay F complete |
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| GO:0055085
transmembrane transport
GOA:interpro |
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| GO:0008144
drug binding PMID:18344567[6] IDA: Inferred from Direct Assay F complete |
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| GO:0055085
transmembrane transport
GOA:interpro |
| |||||||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Source | Notes |
|---|---|---|---|---|
|
plasma membrane C-terminus localized in the cytoplasm with 6 predicted transmembrane domains Daley et al. (2005) [7]
|
| |||
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD RSVLVWMPLV VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI AIRVVSKRFR NISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT YPGRDVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ 582 64.462 kDa 8.8 (calculated) 46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues) |
|---|---|
| Length | |
| Mol. Wt | |
| pI | |
| Extinction coefficient |
|
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
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Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
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| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
- ↑ 6.0 6.1 6.2 6.3 Eckford, PD & Sharom, FJ (2008) Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. J. Biol. Chem. 283 12840-50 PubMed
- ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
Categories
- GO:0005319 ! lipid transporter activity
- GO:0005524 ! ATP binding
- GO:0005886 ! plasma membrane
- GO:0006869 ! lipid transport
- GO:0016020 ! membrane
- GO:0016021 ! integral component of membrane
- GO:0005515 ! protein binding
- GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity
- GO:0008289 ! lipid binding
- GO:0055085 ! transmembrane transport
- GO:0008144 ! drug binding
- TMHMM Prediction
- Proteins
- RefGenome Annotated Gene
