lipB:Gene Product(s): Difference between revisions

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GO:0009107
GO:0003824
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lipoate biosynthetic process
catalytic activity
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PMID:8444795
GOA:interpro<br />GO_REF:0000002
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IMP: Inferred from Mutant Phenotype
IEA: Inferred from Electronic Annotation
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InterPro:IPR004143
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P
F
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Seeded from [[EcoCyc]] (v14.0)
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complete
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GO:0000273
GO:0005737
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lipoic acid metabolic process
cytoplasm
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PMID:1655709
GOA:interpro<br />GO_REF:0000002
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IMP: Inferred from Mutant Phenotype
IEA: Inferred from Electronic Annotation
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InterPro:IPR000544
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P
C
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Seeded from [[EcoCyc]] (v14.0)
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complete
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GO:0030528
GO:0005737
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transcription regulator activity
cytoplasm
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PMID:11072067
GOA:interpro<br />GO_REF:0000002
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IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
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InterPro:IPR020605
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F
C
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Seeded from [[EcoCyc]] (v14.0)
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complete
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GO:0003824
GO:0005737
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catalytic activity
cytoplasm
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GOA:interpro<br />GO_REF:0000002
GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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InterPro:IPR004143
SP_KW:KW-0963
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F
C
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Seeded from [[EcoCyc]] (v14.0)
Seeded from [[EcoCyc]] (v14.0)
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GO:0005737
GO:0009107
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cytoplasm
lipoate biosynthetic process
|
|
GOA:interpro<br />GO_REF:0000002
PMID:8444795
|
|
IEA: Inferred from Electronic Annotation
IMP: Inferred from Mutant Phenotype
|
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InterPro:IPR000544
 
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C
P
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Seeded from [[EcoCyc]] (v14.0)
 
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complete
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Line 257: Line 257:
cytoplasm
cytoplasm
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GOA:interpro<br />GO_REF:0000002
GO_REF:0000023
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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InterPro:IPR020605
SP_SL:SL-0086
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C
C
Line 272: Line 272:


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GO:0005737
GO:0000273
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cytoplasm
lipoic acid metabolic process
|
|
GOA:spkw<br />SP_KW:GO_REF:0000004
PMID:1655709
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IEA: Inferred from Electronic Annotation
IMP: Inferred from Mutant Phenotype
|
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SP_KW:KW-0963
 
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C
P
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|
Seeded from [[EcoCyc]] (v14.0)
 
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complete
|-  
|-  
|
|


|
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GO:0005737
GO:0030528
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|
cytoplasm
transcription regulator activity
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|
GO_REF:0000023
PMID:11072067
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|
IEA: Inferred from Electronic Annotation
IDA: Inferred from Direct Assay
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|
SP_SL:SL-0086
 
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C
F
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Seeded from [[EcoCyc]] (v14.0)
 
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complete
|-  
|-  
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Revision as of 18:00, 17 June 2010

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LipB

Synonyms

lipoyl-protein ligase[1], B0630[2][1], Cde[2][1], LipB[2][1], Lip[2][1], Cde4[2][1], lipoyl-[acyl-carrier-protein]-protein-N-lipoyltransferase[2][1], lipoyl (octanoyl)-acyl carrier protein:protein transferase[2][1]

Product description

lipoyl-protein ligase[2][3]

Lipoyl-protein ligase; lipoyl-[ACP]:protein N-lipoyltransferase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0017118

lipoyltransferase activity

PMID:15642479[5]

IDA: Inferred from Direct Assay

F

complete

GO:0016740

transferase activity

PMID:12591875[6]

IDA: Inferred from Direct Assay

F

complete

GO:0006464

protein modification process

PMID:15642479[5]

IDA: Inferred from Direct Assay

P

complete

GO:0003824

catalytic activity

PMID:15642479[5]

IDA: Inferred from Direct Assay

F

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004143

F

Seeded from EcoCyc (v14.0)

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000544

C

Seeded from EcoCyc (v14.0)

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020605

C

Seeded from EcoCyc (v14.0)

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

GO:0009107

lipoate biosynthetic process

PMID:8444795[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

GO:0000273

lipoic acid metabolic process

PMID:1655709[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030528

transcription regulator activity

PMID:11072067[9]

IDA: Inferred from Direct Assay

F

complete

GO:0006464

protein modification process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004143

P

Seeded from EcoCyc (v14.0)

GO:0008415

acyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00013

F

Seeded from EcoCyc (v14.0)

GO:0008415

acyltransferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc (v14.0)

GO:0009107

lipoate biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000544

P

Seeded from EcoCyc (v14.0)

GO:0009107

lipoate biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020605

P

Seeded from EcoCyc (v14.0)

GO:0016415

octanoyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000544

F

Seeded from EcoCyc (v14.0)

GO:0016415

octanoyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020605

F

Seeded from EcoCyc (v14.0)

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

GO:0033819

lipoyl(octanoyl) transferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.181

F

Seeded from EcoCyc (v14.0)


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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MHEFTDTRDD STLDEIWLVE HYPVFTQGQA GKAEHILMPG DIPVIQSDRG GQVTYHGPGQ
QVMYVLLNLK RRKLGVRELV TLLEQTVVNT LAELGIEAHP RADAPGVYVG EKKICSLGLR
IRRGCSFHGL ALNVNMDLSP FLRINPCGYA GMEMAKISQW KPEATTNNIA PRLLENILAL
LNNPDFEYIT A
Length

191

Mol. Wt

21.309 kDa

pI

6.2 (calculated)

Extinction coefficient

19,940 - 20,315 (calc based on 6 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lipB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11591-MONOMER

UniProt (EcoliWiki Page)

UniProt:P60720

PFAM (EcoliWiki Page)

PFAM:PF03099

RefSeq (EcoliWiki Page)

RefSeq:NP_415163


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Nesbitt, NM et al. (2005) Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase. Protein Expr. Purif. 39 269-82 PubMed
  6. ↑ Jordan, SW & Cronan, JE Jr (2003) The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase. J. Bacteriol. 185 1582-9 PubMed
  7. ↑ Reed, KE & Cronan, JE Jr (1993) Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. J. Bacteriol. 175 1325-36 PubMed
  8. ↑ Vanden Boom, TJ et al. (1991) Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system. J. Bacteriol. 173 6411-20 PubMed
  9. ↑ Vaisvila, R et al. (2000) The LipB protein is a negative regulator of dam gene expression in Escherichia coli. Biochim. Biophys. Acta 1494 43-53 PubMed

Categories

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