lipB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LipB

Synonyms

lipoyl-protein ligase[1], B0630[2][1], Cde[2][1], LipB[2][1], Lip[2][1], Cde4[2][1], lipoyl-[acyl-carrier-protein]-protein-N-lipoyltransferase[2][1], lipoyl (octanoyl)-acyl carrier protein:protein transferase[2][1] , cde, ECK0623, JW5089, b0630

Product description

lipoyl-protein ligase[2][3]

Lipoyl-protein ligase; lipoyl-[ACP]:protein N-lipoyltransferase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0016740

transferase activity

PMID:12591875[5]

IDA: Inferred from Direct Assay

F

complete

GO:0006464

protein modification process

PMID:15642479[6]

IDA: Inferred from Direct Assay

P

complete

GO:0003824

catalytic activity

PMID:15642479[6]

IDA: Inferred from Direct Assay

F

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004143

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000544

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020605

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0009107

lipoate biosynthetic process

PMID:8444795[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0009106

lipoate metabolic process

PMID:1655709[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010629

negative regulation of gene expression

PMID:11072067[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006464

protein modification process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004143

P

Seeded from EcoCyc (v14.0)

complete

GO:0008415

acyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00013

F

Seeded from EcoCyc (v14.0)

complete

GO:0008415

acyltransferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc (v14.0)

complete

GO:0009107

lipoate biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000544

P

Seeded from EcoCyc (v14.0)

complete

GO:0009107

lipoate biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020605

P

Seeded from EcoCyc (v14.0)

complete

GO:0016415

octanoyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000544

F

Seeded from EcoCyc (v14.0)

complete

GO:0016415

octanoyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020605

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0033819

lipoyl(octanoyl) transferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.181

F

Seeded from EcoCyc (v14.0)

complete

GO:0033819

lipoyl(octanoyl) transferase activity

PMID:15642479[6]

IEA: Inferred from Electronic Annotation

F

Seeded from EcoCyc (v23.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MHEFTDTRDD STLDEIWLVE HYPVFTQGQA GKAEHILMPG DIPVIQSDRG GQVTYHGPGQ
QVMYVLLNLK RRKLGVRELV TLLEQTVVNT LAELGIEAHP RADAPGVYVG EKKICSLGLR
IRRGCSFHGL ALNVNMDLSP FLRINPCGYA GMEMAKISQW KPEATTNNIA PRLLENILAL
LNNPDFEYIT A
Length

191

Mol. Wt

21.309 kDa

pI

6.2 (calculated)

Extinction coefficient

19,940 - 20,315 (calc based on 6 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

47..159

PF03099 Biotin/lipoate A/B protein ligase family

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lipB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111156

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945217

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002160

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P60720

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11591

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11591

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945217

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001540

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1549

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Jordan, SW & Cronan, JE Jr (2003) The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase. J. Bacteriol. 185 1582-9 PubMed
  6. ↑ 6.0 6.1 6.2 Nesbitt, NM et al. (2005) Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase. Protein Expr. Purif. 39 269-82 PubMed
  7. ↑ Reed, KE & Cronan, JE Jr (1993) Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. J. Bacteriol. 175 1325-36 PubMed
  8. ↑ Vanden Boom, TJ et al. (1991) Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system. J. Bacteriol. 173 6411-20 PubMed
  9. ↑ Vaisvila, R et al. (2000) The LipB protein is a negative regulator of dam gene expression in Escherichia coli. Biochim. Biophys. Acta 1494 43-53 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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