sucA:Gene Product(s)

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Gene

Gene Product(s)

Expression

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Nomenclature

Function

Interactions

Localization

Sequence

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Structure

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Accessions

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	SucA
Synonyms	2-oxoglutarate decarboxylase, thiamin-requiring
Product description	2-oxoglutarate dehydrogenase, E1 component; yields succinyl-CoA and CO(2)
EC number (for enzymes)	1.2.4.2
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Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm				C	Seeded from Riley et al 2006 .	required fields missing
	GO:0006099	tricarboxylic acid cycle				P	Seeded from Riley et al 2006 .	required field missing
	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011603	F	Seeded from EcoCyc (v14.0)
	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.2.4.2	F	Seeded from EcoCyc (v14.0)
	GO:0005829	cytosol	PMID:16858726	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc (v14.0)
	GO:0006096	glycolysis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011603	P	Seeded from EcoCyc (v14.0)
	GO:0006096	glycolysis	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0324	P	Seeded from EcoCyc (v14.0)
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001017	P	Seeded from EcoCyc (v14.0)
	GO:0016491	oxidoreductase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded from EcoCyc (v14.0)
	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001017	F	Seeded from EcoCyc (v14.0)
	GO:0030976	thiamin pyrophosphate binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011603	F	Seeded from EcoCyc (v14.0)
	GO:0055114	oxidation reduction	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded from EcoCyc (v14.0)
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	hflK		PMID:15690043	Experiment(s):EBI-880717
Protein	lipA		PMID:15690043	Experiment(s):EBI-880717
Protein	lpdA		PMID:15690043	Experiment(s):EBI-880717, EBI-886788
Protein	sucB		PMID:15690043	Experiment(s):EBI-880717, EBI-880739, EBI-886788
Protein	groL		PMID:16606699	Experiment(s):EBI-1137802
Protein	dnaE		PMID:16606699	Experiment(s):EBI-1137802
Protein	oxc		PMID:16606699	Experiment(s):EBI-1137802
Protein	rplC		PMID:15690043	Experiment(s):EBI-886788
Small Molecule	TTTPP	selectively inhibits pyruvate or 2-oxoglutarate dehydrogenase (El).
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Localization

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Compartment	Description	Evidence	Source	Notes
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Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	MRITIILVAP ARAENIGAAA RAMKTMGFSD LRIVDSQAHL EPATRWVAHG SGDIIDNIKV FPTLAESLHD VDFTVATTAR SRAKYHYYAT PVELVPLLEE KSSWMSHAAL VFGREDSGLT NEELALADVL TGVPMVADYP SLNLGQAVMV YCYQLATLIQ QPAKSDATAD QHQLQALRER AMTLLTTLAV ADDIKLVDWL QQRLGLLEQR DTAMLHRLLH DIEKNITK
Length	228
Mol. Wt	25.259 kDa
pI	5.9 (calculated)
Extinction coefficient	25,440 - 25,565 (calc based on 6 Y, 3 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki. Type Residues Description Notes References edit table

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Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki. Structures <beststructure> gene=sucA taxon=562,83333 </beststructure> Models View models at: EcoliPredict ModBase PSI-PRED Protein Quaternary Structure (PQS) Genomes TO Protein (GTOP) edit table

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
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Links

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Name	URL	Comments
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References

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Categories

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