pnp:Quickview: Difference between revisions
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{| | {| id="H49b0202e44d14" class=" tableEdit New_Quickview_Table" | ||
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!align=left | !align=left |Standard Name | ||
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''pnp'' | ''pnp'' | ||
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!align=left | !align=left |Gene Synonym(s) | ||
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''ECK3152, b3164, JW5851, bfl''<ref name='LIB:Riley_2006'/> | ''ECK3152, b3164, JW5851, bfl''<ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left |Product Desc. | ||
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Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; | Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; | ||
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Polynucleotide phosphorylase; exoribonuclease; PNPase component of RNA degradosome; cold shock protein required for growth at low temperatures<ref name='LIB:EcoGene'/> | Polynucleotide phosphorylase; exoribonuclease; PNPase component of RNA degradosome; cold shock protein required for growth at low temperatures<ref name='LIB:EcoGene'/> | ||
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!align=left | !align=left |Product Synonyms(s) | ||
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polynucleotide phosphorylase/polyadenylase<ref name='LIB:Riley_2006'/>, B3164<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Bfl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, polynucleotide phosphorylase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | polynucleotide phosphorylase/polyadenylase<ref name='LIB:Riley_2006'/>, B3164<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Bfl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, polynucleotide phosphorylase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left |Knock-Out Phenotype | ||
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!align=left | !align=left |Regulation/Expression | ||
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transcription unit(s): [[:Category:Txn_unit:rpsO-pnp|rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:pnp|pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp|metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/> | transcription unit(s): [[:Category:Txn_unit:rpsO-pnp|rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:pnp|pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp|metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/> | ||
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!align=left | !align=left |Regulation/Activity | ||
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Revision as of 05:17, 9 January 2010
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
pnp |
|---|---|
| Gene Synonym(s) |
ECK3152, b3164, JW5851, bfl[1] |
| Product Desc. |
Component of polynucleotide phosphorylase[3]; degradosome[3] Polynucleotide phosphorylase; exoribonuclease; PNPase component of RNA degradosome; cold shock protein required for growth at low temperatures[4] |
| Product Synonyms(s) |
polynucleotide phosphorylase/polyadenylase[1], B3164[2][1], Bfl[2][1], Pnp[2][1], polynucleotide phosphorylase[2][1] |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): rpsO-pnp[2], pnp[2], metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp[2] |
| Regulation/Activity |
|
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See Help:Quickview for help with entering information in the Quickview table.
Notes
Implicated in degadation of sRNAs[5]
Cold induction occurs by reversal of post-translational autoregulation. The pnp mRNA leader is cleaved by RNase III, allowing PNPase to repress its own translation. Mutation of Gly454 impairs autogenous regulation without affecting catalytic activity. Mutants have elevated OM vesiculation (McBroom, 2006). Pnp can add long polynucleotide tails to mRNAs terminated by Rho factor (Mohanty, 2006). The overexpression of the Pnp S1 domain suppresses the cold growth defect of quadruple cspABEG mutant strain BX04 (Xia, 2001).[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Andrade, JM & Arraiano, CM (2008) PNPase is a key player in the regulation of small RNAs that control the expression of outer membrane proteins. RNA 14 543-51 PubMed