Category:Complex:degradosome

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Description (originally from EcoCyc[1]) degradosome

Comments (originally from EcoCyc[1]) The degradosome is a large, multiprotein complex involved in RNA degradation. It consists of the RNA degradation enzymes RNase E and PNPase, as well as the ATP-dependent RNA helicase RhlB and the metabolic enzyme enolase [2][3][4][5][6][7][8][9][10][11][12][13][10][14][15][16][16][17][18][19][20][21][22].

Proteomic analysis has been used to examine components of the degradosome[23]

References

  1. ↑ 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ Py, B et al. (1994) A protein complex mediating mRNA degradation in Escherichia coli. Mol. Microbiol. 14 717-29 PubMed
  3. ↑ Carpousis, AJ et al. (1994) Copurification of E. coli RNAase E and PNPase: evidence for a specific association between two enzymes important in RNA processing and degradation. Cell 76 889-900 PubMed
  4. ↑ Py, B et al. (1996) A DEAD-box RNA helicase in the Escherichia coli RNA degradosome. Nature 381 169-72 PubMed
  5. ↑ Blum, E et al. (1997) Polyphosphate kinase is a component of the Escherichia coli RNA degradosome. Mol. Microbiol. 26 387-98 PubMed
  6. ↑ Miczak, A et al. (1996) Proteins associated with RNase E in a multicomponent ribonucleolytic complex. Proc. Natl. Acad. Sci. U.S.A. 93 3865-9 PubMed
  7. ↑ Coburn, GA et al. (1999) Reconstitution of a minimal RNA degradosome demonstrates functional coordination between a 3' exonuclease and a DEAD-box RNA helicase. Genes Dev. 13 2594-603 PubMed
  8. ↑ Liou, GG et al. (2001) RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E. Proc. Natl. Acad. Sci. U.S.A. 98 63-8 PubMed
  9. ↑ Kido, M et al. (1996) RNase E polypeptides lacking a carboxyl-terminal half suppress a mukB mutation in Escherichia coli. J. Bacteriol. 178 3917-25 PubMed
  10. ↑ 10.0 10.1 Vanzo, NF et al. (1998) Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome. Genes Dev. 12 2770-81 PubMed
  11. ↑ Morita, T et al. (2004) Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli. Mol. Microbiol. 54 1063-75 PubMed
  12. ↑ Callaghan, AJ et al. (2004) Studies of the RNA degradosome-organizing domain of the Escherichia coli ribonuclease RNase E. J. Mol. Biol. 340 965-79 PubMed
  13. ↑ Leroy, A et al. (2002) Function in Escherichia coli of the non-catalytic part of RNase E: role in the degradation of ribosome-free mRNA. Mol. Microbiol. 45 1231-43 PubMed
  14. ↑ Coburn, GA & Mackie, GA (1998) Reconstitution of the degradation of the mRNA for ribosomal protein S20 with purified enzymes. J. Mol. Biol. 279 1061-74 PubMed
  15. ↑ Khemici, V & Carpousis, AJ (2004) The RNA degradosome and poly(A) polymerase of Escherichia coli are required in vivo for the degradation of small mRNA decay intermediates containing REP-stabilizers. Mol. Microbiol. 51 777-90 PubMed
  16. ↑ 16.0 16.1 Blum, E et al. (1999) Polyadenylation promotes degradation of 3'-structured RNA by the Escherichia coli mRNA degradosome in vitro. J. Biol. Chem. 274 4009-16 PubMed
  17. ↑ Bessarab, DA et al. (1998) RNA components of Escherichia coli degradosome: evidence for rRNA decay. Proc. Natl. Acad. Sci. U.S.A. 95 3157-61 PubMed
  18. ↑ Lin-Chao, S et al. (1999) RNase E is required for the maturation of ssrA RNA and normal ssrA RNA peptide-tagging activity. Proc. Natl. Acad. Sci. U.S.A. 96 12406-11 PubMed
  19. ↑ Khemici, V et al. (2004) The RNase E of Escherichia coli has at least two binding sites for DEAD-box RNA helicases: functional replacement of RhlB by RhlE. Mol. Microbiol. 54 1422-30 PubMed
  20. ↑ Prud'homme-Généreux, A et al. (2004) Physical and functional interactions among RNase E, polynucleotide phosphorylase and the cold-shock protein, CsdA: evidence for a 'cold shock degradosome'. Mol. Microbiol. 54 1409-21 PubMed
  21. ↑ Feng, Y et al. (2001) Escherichia coli poly(A)-binding proteins that interact with components of degradosomes or impede RNA decay mediated by polynucleotide phosphorylase and RNase E. J. Biol. Chem. 276 31651-6 PubMed
  22. ↑ Bernstein, JA et al. (2004) Global analysis of Escherichia coli RNA degradosome function using DNA microarrays. Proc. Natl. Acad. Sci. U.S.A. 101 2758-63 PubMed
  23. ↑ Regonesi, ME et al. (2006) Analysis of the Escherichia coli RNA degradosome composition by a proteomic approach. Biochimie 88 151-61 PubMed

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