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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''mrcA''  
''mrcA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK3383, b3396, JW3359, ponA''<ref name='LIB:Riley_2006'/>
''ECK3383, b3396, JW3359, ponA''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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peptidoglycan synthetase; penicillin-binding protein 1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
peptidoglycan synthetase; penicillin-binding protein 1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric<ref name='LIB:EcoGene'/>
Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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fused penicillin-binding protein 1a: murein transglycosylase<ref name='LIB:Riley_2006'/>, murein transpeptidase<ref name='LIB:Riley_2006'/>, B3396<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
fused penicillin-binding protein 1a: murein transglycosylase<ref name='LIB:Riley_2006'/>, murein transpeptidase<ref name='LIB:Riley_2006'/>, B3396<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Cellular Component'''
* GO:0005887 integral to plasma membrane ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0042493 response to drug ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Molecular Function'''
* GO:0008955 peptidoglycan glycosyltransferase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:mrcA|mrcA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mrcA|mrcA]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=mrcA&loc=MG1655:3520893..3523445,W3110:4117545..4114993,REL606:3451553..3454105,DH10B:3618638..3621190 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3618638&end=3621190&gene=mrcA&aa=mklngkfpvkfvkyflilavccillgagsiyglyryiepqlpdvatlkdvrlqipmqiysadgeliaqygekrripvtldqippemvkafiatedsrfyehhgvdpvgifraasvalfsghasqgastitqqlarnfflspertlmrkikevflairieqlltkdeilelylnkiylgyraygvgaaaqvyfgktvdqltlnemaviaglpkapstfnplysmdravarrnvvlsrmldegyitqqqfdqtrteainanyhapeiafsapylsemvrqemynrygesayedgyriyttitrkvqqaaqqavrnnvldydmrhgyrgpanvlwkvgesawdnnkitdtlkalptygpllpaavtsanpqqatamladgstvalsmegvrwarpyrsdtqqgptprkvtdvlqtgqqiwvrqvgdawwlaqvpevnsalvsinpqngavmalvggfdfnqskfnratqalrqvgsnikpflytaamdkgltlasmlndvpisrwdasagsdwqpknsppqyagpirlrqglgqsknvvmvramramgvdyaaeylqrfgfpaqnivhteslalgsasftpmqvargyavmanggflvdpwfiskiendqggvifeakpkvacpecdipviygdtqksnvlenndvedvaisreqqnvsvpmpqleqanqalvaktgaqeyaphvintplafliksalntnifgepgwqgtgwragrdlqrrdiggktgttnsskdawfsgygpgvvtsvwigfddhrrnlghttasgaikdqisgyeggaksaqpawdaymkavlegvpeqpltpppgivtvnidrstgqlanggnsreeyfiegtqptqqavhevgttiidngeaqelf Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mrcA+AND+escherichia+coli Pubmed(mrcA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=mrcA Textpresso(mrcA)]


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Revision as of 23:42, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

mrcA

Gene Synonym(s)

ECK3383, b3396, JW3359, ponA[1]

Product Desc.

peptidoglycan synthetase; penicillin-binding protein 1A[2][3]

Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric[4]

Product Synonyms(s)

fused penicillin-binding protein 1a: murein transglycosylase[1], murein transpeptidase[1], B3396[2][1], PonA[2][1], MrcA[2][1], PBP1A[2][1]

Function from GO

Cellular Component

Biological Process

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mrcA[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(mrcA)    Textpresso(mrcA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Several phenotypes were associated with an mrcA deletion strain that inadvertantly deleted two neighboring genes, nudE(yrfE) and yrfF. One or both of these other genes turned out to be responsible for the observed mrcA-associated phenotypes. Murein polymerase is an essential function satisfied by either MrcA or MrcB. MrcA contains a PDZ domain involved in substrate recognition. MrcA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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