sucA:Gene Product(s): Difference between revisions

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SP_KW:KW-0560
SP_KW:KW-0560
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F
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Seeded from EcoCyc
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complete
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GO:0016624
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oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
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GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001017
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F
F
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GO:0016624
GO:0030976
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oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
thiamin pyrophosphate binding
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GO_REF:0000002
GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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InterPro:IPR001017
InterPro:IPR011603
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F
F

Revision as of 07:16, 22 May 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SucA

Synonyms

2-oxoglutarate decarboxylase, thiamin-requiring[1]

Product description


2-oxoglutarate dehydrogenase, E1 component; yields succinyl-CoA and CO(2)[2]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0030976

thiamin pyrophosphate binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

F

Seeded from EcoCyc [3]

complete

GO:0016624

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

F

Seeded from EcoCyc [3]

complete

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc [3]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

P

Seeded from EcoCyc [3]

complete

GO:0006096

glycolysis

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR011603
SP_KW:KW-0324

P

Seeded from EcoCyc [3]

complete

GO:0004591

oxoglutarate dehydrogenase (succinyl-transferring) activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR011603
EC:1.2.4.2

F

Seeded from EcoCyc [3]

complete

GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

required fields missing

GO:0005829

cytosol

PMID:16858726[4]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [3]

complete

GO:0055114

oxidation reduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc [3]

complete

GO:0004591

oxoglutarate dehydrogenase (succinyl-transferring) activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR011603
EC:1.2.4.2

F

Seeded from EcoCyc

complete

GO:0005829

cytosol

PMID:16858726[4]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc

complete

GO:0006096

glycolysis

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR011603
SP_KW:KW-0324

P

Seeded from EcoCyc

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

P

Seeded from EcoCyc

complete

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc

complete

GO:0016624

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

F

Seeded from EcoCyc

complete

GO:0006099

tricarboxylic acid cycle

P

Seeded from Riley et al 2006 [1].

required field missing

GO:0030976

thiamin pyrophosphate binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

F

Seeded from EcoCyc

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

hflK

PMID:15690043[5]

Experiment(s):EBI-880717

Protein

lipA

PMID:15690043[5]

Experiment(s):EBI-880717

Protein

lpdA

PMID:15690043[5]

Experiment(s):EBI-880717, EBI-886788

Protein

sucB

PMID:15690043[5]

Experiment(s):EBI-880717, EBI-880739, EBI-886788

Protein

groL

PMID:16606699[6]

Experiment(s):EBI-1137802

Protein

dnaE

PMID:16606699[6]

Experiment(s):EBI-1137802

Protein

oxc

PMID:16606699[6]

Experiment(s):EBI-1137802

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-886788

Small Molecule

TTTPP

selectively inhibits pyruvate or 2-oxoglutarate dehydrogenase (El).


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence 
MRITIILVAP ARAENIGAAA RAMKTMGFSD LRIVDSQAHL EPATRWVAHG SGDIIDNIKV
FPTLAESLHD VDFTVATTAR SRAKYHYYAT PVELVPLLEE KSSWMSHAAL VFGREDSGLT
NEELALADVL TGVPMVADYP SLNLGQAVMV YCYQLATLIQ QPAKSDATAD QHQLQALRER
AMTLLTTLAV ADDIKLVDWL QQRLGLLEQR DTAMLHRLLH DIEKNITK
Length

228

Mol. Wt

25230.79 Da (calc)

pI

5.58

Extinction coefficient

25502.5 (calc)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes
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<motif_map/>

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>sucA 562</beststructure>

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  4. ↑ 4.0 4.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed


Categories

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