dnaA:Quickview: Difference between revisions
imported>Wikientrybot Move help links into the <above> tag inside templates. |
imported>Wikientrybot Adding EcoGene Comments |
||
| Line 60: | Line 60: | ||
===Notes=== | ===Notes=== | ||
{{BacktoTop}} | {{BacktoTop}} | ||
DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. Acidic phospholipids release bound ADP, reactivating DnaA by allowing ATP to rebind. Null mutations in seqA, yccV or rpoN suppress dna46(Ts). Increases in DnaA levels reduce Fis oriC primary binding thus allowing DnaA to bind, this may play a role in the dynamics of prereplication complexes. Collapsed replication forks (primarily within 10 map units of oriC) are a result of the level of initiation induced by elevated dnaA expression. Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008).<ref name='LIB:EcoGene'/> | |||
Revision as of 23:40, 2 March 2009
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name | |
|---|---|
| Product(s) |
DnaA product[1]: chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator product, B3702 product, DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator product |
| Description | |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): dnaAN-recF[2] |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. Acidic phospholipids release bound ADP, reactivating DnaA by allowing ATP to rebind. Null mutations in seqA, yccV or rpoN suppress dna46(Ts). Increases in DnaA levels reduce Fis oriC primary binding thus allowing DnaA to bind, this may play a role in the dynamics of prereplication complexes. Collapsed replication forks (primarily within 10 map units of oriC) are a result of the level of initiation induced by elevated dnaA expression. Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008).[4]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.