pnp:Quickview: Difference between revisions
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Implicated in degadation of sRNAs<ref name='PMID:18203924'/> | Implicated in degadation of sRNAs<ref name='PMID:18203924'/> | ||
Cold induction occurs by reversal of post-translational autoregulation. The pnp mRNA leader is cleaved by RNase III, allowing PNPase to repress its own translation. Mutation of Gly454 impairs autogenous regulation without affecting catalytic activity. Mutants have elevated OM vesiculation (McBroom, 2006). Pnp can add long polynucleotide tails to mRNAs terminated by Rho factor (Mohanty, 2006). The overexpression of the Pnp S1 domain suppresses the cold growth defect of quadruple cspABEG mutant strain BX04 (Xia, 2001).<ref name='LIB:EcoGene'/> | |||
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Revision as of 00:22, 3 March 2009
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name | |
|---|---|
| Product(s) |
Pnp product[1]: polynucleotide phosphorylase/polyadenylase product, B3164 product, Bfl product, polynucleotide phosphorylase product |
| Description |
Component of polynucleotide phosphorylase[3],degradosome[3] |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): rpsO-pnp[2], pnp[2], metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp[2] |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
Implicated in degadation of sRNAs[4]
Cold induction occurs by reversal of post-translational autoregulation. The pnp mRNA leader is cleaved by RNase III, allowing PNPase to repress its own translation. Mutation of Gly454 impairs autogenous regulation without affecting catalytic activity. Mutants have elevated OM vesiculation (McBroom, 2006). Pnp can add long polynucleotide tails to mRNAs terminated by Rho factor (Mohanty, 2006). The overexpression of the Pnp S1 domain suppresses the cold growth defect of quadruple cspABEG mutant strain BX04 (Xia, 2001).[5]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Andrade, JM & Arraiano, CM (2008) PNPase is a key player in the regulation of small RNAs that control the expression of outer membrane proteins. RNA 14 543-51 PubMed
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.