glnB:Quickview: Difference between revisions
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GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. In nitrogen limitation GlnB is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. GlnB interacts with and regulates the activities of the histidine protein kinase NtrB, which controls phosphorylation of NtrC. It also regulates the activity of adenylyltransferase (GlnE) which in turn regulates the activity of glutamine synthetase (GlnA). glnK is a glnB paralog. [Comment provided by EcoTeam member Mike Merrick, 11.16.06]<ref name='LIB:EcoGene'/> | |||
Revision as of 23:52, 2 March 2009
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name | |
|---|---|
| Product(s) |
GlnB product, GlnB product[1][2]: B2553 product, [protein PII] product, unmodified PII product |
| Description | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. In nitrogen limitation GlnB is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. GlnB interacts with and regulates the activities of the histidine protein kinase NtrB, which controls phosphorylation of NtrC. It also regulates the activity of adenylyltransferase (GlnE) which in turn regulates the activity of glutamine synthetase (GlnA). glnK is a glnB paralog. [Comment provided by EcoTeam member Mike Merrick, 11.16.06][4]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.