msbA:Gene Product(s): Difference between revisions

Standard name	MsbA product
Synonyms	fused lipid transporter subunits of ABC superfamily: membrane component product^[1], ATP-binding component product^[1], B0914 product^[2]^[1], MsbA product^[2]^[1]
Product description	ATP-binding transport protein^[2]^[3]
EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes
	GO:0016021	integral_to_membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011917	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0016021	integral_to_membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0006869	lipid_transport	PMID:11278265^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded from EcoCyc 12.5 ^[4]
	GO:0009276	cell_wall_(sensu_Proteobacteria)	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011917	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0015437	lipopolysaccharide-transporting_ATPase_activity	PMID:12119303^[6]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc 12.5 ^[4]
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0397	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0016021	integral_to_membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0016021	integral_to_membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0006869	lipid_transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0445	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0005524	ATP_binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005524	ATP_binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005524	ATP_binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011917	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005524	ATP_binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005524	ATP_binding	PMID:8809774^[7]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005624	membrane_fraction	PMID:16858726^[8]	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc 12.5 ^[4]
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0006869	lipid_transport	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01703	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0006869	lipid_transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011917	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0000166	nucleotide_binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005319	lipid_transporter_activity	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01703	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005319	lipid_transporter_activity	PMID:11278265^[5]	IMP: Inferred from Mutant Phenotype		F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005524	ATP_binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0000166	nucleotide_binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0016787	hydrolase_activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded from EcoCyc 12.5 ^[4]
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Interactions

Partner Type	Partner	Notes
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Notes

Localization

Compartment	Description	Evidence	Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD RSVLVWMPLV VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI AIRVVSKRFR NISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT YPGRDVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ
Mol. Wt	64.46 kDa (calc) ^[2]
pI
Extinction coefficient	46870 - 47120 (calc based on 13 Y, 5 W, and 2 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structure Type	Organism	Accession	Residues covered	Notes
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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:EG10613-MONOMER
UniProt (EcoliWiki Page)	UniProt:P60752
PFAM (EcoliWiki Page)	PFAM:PF00664
RefSeq (EcoliWiki Page)	RefSeq:NP_415434
ModBase (EcoliWiki Page)	ModBase:P60752
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 ^4.25 ^4.26 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^5.0 ^5.1 Doerrler, WT et al. (2001) An Escherichia coli mutant defective in lipid export. J. Biol. Chem. 276 11461-4 PubMed
↑ Doerrler, WT & Raetz, CR (2002) ATPase activity of the MsbA lipid flippase of Escherichia coli. J. Biol. Chem. 277 36697-705 PubMed
↑ Polissi, A & Georgopoulos, C (1996) Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter. Mol. Microbiol. 20 1221-33 PubMed
↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed

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 InterPro:IPR011917
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+C
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+Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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+|-
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+[[Category:GO:0016021_!_integral_to_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016021_!_integral_to_membrane GO:0016021]
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+integral_to_membrane
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+[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
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+IEA: Inferred from Electronic Annotation
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+SP_KW:KW-0812
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 C
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-[[Category:GO:0016021_!_integral_to_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016021_!_integral_to_membrane GO:0016021]
+[[Category:GO:0016787_!_hydrolase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016787_!_hydrolase_activity GO:0016787]
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-integral_to_membrane
+hydrolase_activity
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 [http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
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 IEA: Inferred from Electronic Annotation
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-SP_KW:KW-0812
+SP_KW:KW-0378
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-C
+F
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 Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>

msbA:Gene Product(s): Difference between revisions

Revision as of 03:08, 30 September 2008

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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msbA:Gene Product(s): Difference between revisions

Revision as of 03:08, 30 September 2008

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

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