rpsL:Quickview: Difference between revisions
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!align=left | !align=left {{table_heading_style}} |Standard Name | ||
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''rpsL'' | ''rpsL'' | ||
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!align=left | !align=left {{table_heading_style}} |Gene Synonym(s) | ||
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''ECK3329, b3342, JW3304, asuB, strA''<ref name='LIB:Riley_2006'/> | ''ECK3329, b3342, JW3304, asuB, strA''<ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left {{table_heading_style}} |Product Desc. | ||
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30S ribosomal subunit protein S12<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; | 30S ribosomal subunit protein S12<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; | ||
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30S ribosomal subunit protein S12; RNA chaperone<ref name='LIB:EcoGene'/> | 30S ribosomal subunit protein S12; RNA chaperone<ref name='LIB:EcoGene'/> | ||
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!align=left | !align=left {{table_heading_style}} |Product Synonyms(s) | ||
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30S ribosomal subunit protein S12<ref name='LIB:Riley_2006'/>, B3342<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, StrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AsuB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RpsL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | 30S ribosomal subunit protein S12<ref name='LIB:Riley_2006'/>, B3342<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, StrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AsuB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RpsL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left {{table_heading_style}} |Function from GO | ||
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'''Biological Process''' | |||
* GO:0000372 Group I intron splicing ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
* GO:0033120 positive regulation of RNA splicing ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
* GO:0034337 RNA folding ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
* GO:0006412 translation ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
'''Molecular Function''' | |||
* GO:0034336 misfolded RNA binding ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
* GO:0003735 structural constituent of ribosome ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
'''Cellular Component''' | |||
* GO:0022627 cytosolic small ribosomal subunit ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
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!align=left | !align=left {{table_heading_style}} |Knock-Out Phenotype | ||
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!align=left {{table_heading_style}} |Regulation/Expression | |||
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transcription unit(s): [[:Category:Txn_unit:rpsLG-fusA-tufA|rpsLG-fusA-tufA]]<ref name='LIB:EcoCyc10.6'/> | transcription unit(s): [[:Category:Txn_unit:rpsLG-fusA-tufA|rpsLG-fusA-tufA]]<ref name='LIB:EcoCyc10.6'/> | ||
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!align=left | !align=left {{table_heading_style}} |Regulation/Activity | ||
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!align=left {{table_heading_style}} |Quick Links | |||
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[http://ecoliwiki.net/tools/display_dna.php?gene=rpsL&loc=MG1655:3472574..3472200,W3110:4165864..4166238,REL606:3402457..3402083 DNA display] [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3402457&end=3402083&gene=rpsL&aa=matvnqlvrkprarkvaksnvpaleacpqkrgvctrvytttpkkpnsalrkvcrvrltngfevtsyiggeghnlqehsvilirggrvkdlpgvryhtvrgaldcsgvkdrkqarskygvkrpka Protein display] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=rpsL+AND+escherichia+coli Pubmed(rpsL)] [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=rpsL Textpresso(rpsL)] | |||
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Revision as of 23:34, 21 January 2010
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
rpsL |
|---|---|
| Gene Synonym(s) |
ECK3329, b3342, JW3304, asuB, strA[1] |
| Product Desc. |
30S ribosomal subunit protein S12[2][3]; Component of 30S ribosomal subunit[2][3]; ribosome[2][3] 30S ribosomal subunit protein S12; RNA chaperone[4] |
| Product Synonyms(s) |
30S ribosomal subunit protein S12[1], B3342[2][1], StrA[2][1], AsuB[2][1], RpsL[2][1] |
| Function from GO |
Biological Process
Molecular Function
Cellular Component
|
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): rpsLG-fusA-tufA[2] |
| Regulation/Activity | |
| Quick Links | |
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
RpsL is a ribosomal gene that encodes the highly conserved rps12 protein of the ribosomal accuracy center in the Escherichia coli. Numerous mutations in the rpsL gene generate resistance to, and in some instances dependence on, high levels of streptomycin. [5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Toivonen, JM et al. (1999) Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL. Mol. Microbiol. 31 1735-46 PubMed
Mutations in regions 41-45 (except when lys42 is replaced with arg), 87-93 and 53 result in streptomycin resistance. A point mutation at 262 from A to G sustains protein synthesis in late stationary phase and increases the stability of the 70S complex in low magnesium concentrations.[1]