Category:Complex:ribosome
- The ribosome is a complex cellular machine where proteins are synthesized. The ribosome must translate the nucleic acid sequence (genetic code) of mRNAs into the amino acid sequence of proteins . [1][2]
- Ribosomes are the components of cells that make proteins from amino acids directed by an RNA template (mRNA).[3]
- A typical bacterial ribosome is made up of 3 RNA molecules and 54 polypeptides. The small ribosomal subunit consists of 16S rRNA and 21 polypeptides. The large ribosomal subunit consists of 23S rRNA and 5S rRNA and 33 polypeptides.<need ref>
- A crystal structure of the E. coli ribosome has been determined at 3.5 Å resolution [4][5][6][7]
References
- ↑ EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ http://en.wikipedia.org/wiki/Ribosome
- ↑ Schuwirth, BS et al. (2005) Structures of the bacterial ribosome at 3.5 A resolution. Science 310 827-34 PubMed
- ↑ Ramakrishnan, V (2002) Ribosome structure and the mechanism of translation. Cell 108 557-72 PubMed
- ↑ Yonath, A (2005) Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation. Annu. Rev. Biochem. 74 649-79 PubMed
- ↑ Ogle, JM & Ramakrishnan, V (2005) Structural insights into translational fidelity. Annu. Rev. Biochem. 74 129-77 PubMed
