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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''pnp''  
''pnp''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK3152, b3164, JW5851, bfl''<ref name='LIB:Riley_2006'/>
''ECK3152, b3164, JW5851, bfl''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Polynucleotide phosphorylase; exoribonuclease; PNPase component of RNA degradosome; cold shock protein required for growth at low temperatures<ref name='LIB:EcoGene'/>
Polynucleotide phosphorylase; exoribonuclease; PNPase component of RNA degradosome; cold shock protein required for growth at low temperatures<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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polynucleotide phosphorylase/polyadenylase<ref name='LIB:Riley_2006'/>, B3164<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Bfl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, polynucleotide phosphorylase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
polynucleotide phosphorylase/polyadenylase<ref name='LIB:Riley_2006'/>, B3164<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Bfl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, polynucleotide phosphorylase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Cellular Component'''
* GO:0005624 membrane fraction ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005739 mitochondrion ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005829 cytosol ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:rpsO-pnp|rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:pnp|pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp|metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:rpsO-pnp|rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:pnp|pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp|metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=pnp&loc=MG1655:3309259..3307055,W3110:3311092..3308888,DH10B:3407004..3404800,REL606:3246471..3244267 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3246471&end=3244267&gene=pnp&aa=mrrrsgintsavryclrkrkditllnpivrkfqygqhtvtletgmmarqataavmvsmddtavfvtvvgqkkakpgqdffpltvnyqertyaagripgsffrregrpsegetliarlidrpirplfpegfvnevqviatvvsvnpqvnpdivamigasaalslsgipfngpigaarvgyindqyvlnptqdelkeskldlvvagteaavlmveseaqllsedqmlgavvfgheqqqvviqninelvkeagkprwdwqpepvnealnarvaalaearlsdayritdkqeryaqvdviksetiatllaedetldenelgeilhaieknvvrsrvlagepridgrekdmirgldvrtgvlprthgsalftrgetqalvtatlgtardaqvldelmgertdtflfhynfppysvgetgmvgspkrreighgrlakrgvlavmpdmdkfpytvrvvseitesngsssmasvcgaslalmdagvpikaavagiamglvkegdnyvvlsdilgdedhlgdmdfkvagsrdgisalqmdikiegitkeimqvalnqakgarlhilgvmeqainaprgdisefaprihtikinpdkikdvigkggsviralteetgttieieddgtvkiaatdgekakhairrieeitaeievgrvytgkvtrivdfgafvaigggkeglvhisqiadkrvekvtdylqmgqevpvkvlevdrqgrirlsikeateqsqpaaapeapaaeqge Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=pnp+AND+escherichia+coli Pubmed(pnp)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=pnp Textpresso(pnp)]


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Revision as of 00:19, 22 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

pnp

Gene Synonym(s)

ECK3152, b3164, JW5851, bfl[1]

Product Desc.

Pnp[2][3];

Component of polynucleotide phosphorylase[3]; degradosome[3]

Polynucleotide phosphorylase; exoribonuclease; PNPase component of RNA degradosome; cold shock protein required for growth at low temperatures[4]

Product Synonyms(s)

polynucleotide phosphorylase/polyadenylase[1], B3164[2][1], Bfl[2][1], Pnp[2][1], polynucleotide phosphorylase[2][1]

Function from GO

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): rpsO-pnp[2], pnp[2], metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(pnp)    Textpresso(pnp)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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Implicated in degadation of sRNAs[5]

Cold induction occurs by reversal of post-translational autoregulation. The pnp mRNA leader is cleaved by RNase III, allowing PNPase to repress its own translation. Mutation of Gly454 impairs autogenous regulation without affecting catalytic activity. Mutants have elevated OM vesiculation (McBroom, 2006). Pnp can add long polynucleotide tails to mRNAs terminated by Rho factor (Mohanty, 2006). The overexpression of the Pnp S1 domain suppresses the cold growth defect of quadruple cspABEG mutant strain BX04 (Xia, 2001).[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Andrade, JM & Arraiano, CM (2008) PNPase is a key player in the regulation of small RNAs that control the expression of outer membrane proteins. RNA 14 543-51 PubMed
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