glnB:Quickview: Difference between revisions

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{{Tab On|Quickview|glnB}}{{Tab|Gene|glnB}}{{Tab|Gene Product(s)|glnB}}{{Tab|Expression|glnB}}{{Tab|Evolution|glnB}}{{Tab|On One Page|glnB}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[glnB:Gene|''glnB]]'' (synonyms: ''ECK2550, b2553, JW2537'')<ref name='LIB:Riley_2006'/>
''glnB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[glnB:Gene_Product(s)|GlnB product, GlnB product]]<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>: B2553 product, [protein PII] product, unmodified PII product
''ECK2550, b2553, JW2537''<ref name='LIB:Riley_2006'/>, JW2537''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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PII<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
PII<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>, PII-UMP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>,
 
Component of [[:Category:Complex:PII|PII]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Component of [[:Category:Complex:PII|PII]]<ref name='LIB:EcoCyc10.6'/>


PII regulatory protein for glutamine synthase; potent activator of NRII/GlnL/NtrB phosphatase and inhibitor of NRII autophosphorylation; activates adenylation of GlnA by GlnE<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''regulatory protein P-II for glutamine synthetase<ref name='LIB:Riley_2006'/>, B2553<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>,[protein PII]<ref name='LIB:EcoCyc10.6'/>, uridylyl-[protein PII]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2550, JW2537, b2553''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:glnB|glnB]]<ref name='LIB:EcoCyc10.6'/>, OP00126  
transcription unit(s): [[:Category:Txn_unit:glnB|glnB]]<ref name='LIB:EcoCyc10.6'/>, OP00126  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=glnB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10384]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000377&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=glnB&loc=MG1655%3A2685430..2685092,W3110%3A2686064..2685726,DH10B%3A2777195..2776857,REL606%3A2608107..2607769,BW2952%3A2570897..2571235]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2570897&end=2571235&gene=glnB&aa=mkkidaiikpfklddvrealaevgitgmtvtevkgfgrqkghtelyrgaeymvdflpkvkieivvpddivdtcvdtiirtaqtgkigdgkifvfdvarvirirtgeeddaai]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=glnB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=glnB]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. In nitrogen limitation GlnB is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions.  GlnB interacts with and regulates the activities of the histidine protein kinase NtrB, which controls phosphorylation of NtrC.  It also regulates the activity of adenylyltransferase (GlnE) which in turn regulates the activity of glutamine synthetase (GlnA). glnK is a glnB paralog. [Comment provided by EcoTeam member Mike Merrick, 11.16.06]<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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<references/>
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Latest revision as of 21:50, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

glnB

Gene Synonym(s)

ECK2550, b2553, JW2537[1], JW2537

Product Desc.

PII[2][3], PII-UMP[2][3],

Component of PII[2][3]


PII regulatory protein for glutamine synthase; potent activator of NRII/GlnL/NtrB phosphatase and inhibitor of NRII autophosphorylation; activates adenylation of GlnA by GlnE[4]

Product Synonyms(s)

regulatory protein P-II for glutamine synthetase[1], B2553[2][1],[protein PII][2], uridylyl-[protein PII][2][1] , ECK2550, JW2537, b2553

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): glnB[2], OP00126

Regulation/Activity
Quick Links



        

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Notes

[back to top]


GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. In nitrogen limitation GlnB is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. GlnB interacts with and regulates the activities of the histidine protein kinase NtrB, which controls phosphorylation of NtrC. It also regulates the activity of adenylyltransferase (GlnE) which in turn regulates the activity of glutamine synthetase (GlnA). glnK is a glnB paralog. [Comment provided by EcoTeam member Mike Merrick, 11.16.06][4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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