fabI:Gene Product(s): Difference between revisions

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*  
*  
****************************************************************************************** -->{{Product_nomenclature_help}}
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{| id="N46aa61d7b3c6e"  class=" tableEdit Product_nomenclature_table"   
{|   id="N46aa61d7b3c6e"  class=" tableEdit Product_nomenclature_table"   


|-
|-
!align=left |Standard name
!align=left {{table heading style}} |Standard name
||
||
FabI  
FabI  
|-
|-
!align=left |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
enoyl-[acyl-carrier-protein] reductase, NADH-dependent<ref name='LIB:Riley_2006'/>, B1288<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Gts<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, QmeA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EnvM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FabI<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''enoyl-[acyl-carrier-protein] reductase, NADH-dependent<ref name='LIB:Riley_2006'/>, B1288<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Gts<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, QmeA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EnvM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FabI<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1283, envM, gts, JW1281, qmeA, b1288''
|-
|-
!align=left |Product description
!align=left {{table heading style}} |Product description
||
||
ENOYL-ACP-REDUCT-NADH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
ENOYL-ACP-REDUCT-NADH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Enoyl-ACP reductase, NADH dependent<ref name='LIB:EcoGene'/>
Enoyl-ACP reductase, NADH dependent<ref name='LIB:EcoGene'/>
|-
|-
!align=left |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
||
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* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]<ref name='LIB:Riley_2006'/>
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]<ref name='LIB:Riley_2006'/>
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*  
*  
****************************************************************************************** -->{{Product_GO_help}}
****************************************************************************************** -->{{Product_GO_help}}
{|   id="O46aa61d8c0fe1"  class=" tableEdit GO_table_product dataTable"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="O46aa61d8c0fe1"  class=" tableEdit GO_table_product dataTable"   
|-
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0003824
|
catalytic activity
|
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-  
|-  
|
|


|
|
GO:0046677
GO:0004318
|
|
response to antibiotic
enoyl-(acyl-carrier-protein) reductase (NADH) activity
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0046
InterPro:IPR014358
|
|
P
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 101: Line 120:


|
|
GO:0016491
GO:0004318
|
|
oxidoreductase activity
enoyl-(acyl-carrier-protein) reductase (NADH) activity
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
GOA:spec<br />GO_REF:0000003
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|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR002198<br />InterPro:IPR002347<br />SP_KW:KW-0560
EC:1.3.1.9
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0016020
GO:0005886
|
plasma membrane
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GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
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C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0005886
|
|
membrane
plasma membrane
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GO_REF:0000004<br />GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0397<br />SP_KW:KW-0472
SP_KW:KW-1003
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|
C
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0006633
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fatty acid biosynthetic process
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GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR014358
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P
|
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0008610
GO:0006633
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fatty acid biosynthetic process
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GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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SP_KW:KW-0275
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P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
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GO:0008152
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|
lipid biosynthetic process
metabolic process
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GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
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|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0444
InterPro:IPR002198
|
|
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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metabolic process
metabolic process
|
|
GO_REF:0000002<br />GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR002198<br />InterPro:IPR002347
InterPro:IPR002347
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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GO:0006633
GO:0008152
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|
fatty acid biosynthetic process
metabolic process
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|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0275
InterPro:IPR016040
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0004318
GO:0008610
|
|
enoyl-(acyl-carrier-protein) reductase (NADH) activity
lipid biosynthetic process
|
|
GO_REF:0000003
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
EC:1.3.1.9
SP_KW:KW-0444
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0005515
GO:0016020
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|
protein binding
membrane
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PMID:15690043
GOA:spkw<br />SP_KW:GO_REF:0000004
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|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0AF90
SP_KW:KW-0472
|
|
F
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0005624
GO:0016020
|
|
membrane fraction
membrane
|
|
PMID:16858726
PMID:16858726
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C
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
|
GO:0005737
GO:0016491
|
|
cytoplasm
oxidoreductase activity
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GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR002198
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|
C
F
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
GO:0003824
GO:0016491
|
|
catalytic activity
oxidoreductase activity
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR016040
InterPro:IPR002347
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0005488
GO:0016491
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|
binding
oxidoreductase activity
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GO_REF:0000002
GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR016040
SP_KW:KW-0560
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 310: Line 386:


|
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GO:0005739
GO:0019898
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|
mitochondrion
extrinsic to membrane
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PMID:16858726
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9903
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
|
IDA: Inferred from Direct Assay
complete
|-
|
|


|
|
C
GO:0046677
|
response to antibiotic
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GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0046
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P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0005886
GO:0055114
|
|
plasma membrane
oxidation reduction
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GO_REF:0000004<br />GO_REF:0000004<br />GO_REF:0000023
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0997<br />SP_KW:KW-1003<br />SP_SL:SL-0037
InterPro:IPR002347
|
|
C
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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oxidation reduction
oxidation reduction
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GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0560
InterPro:IPR014358
|
|
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
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GO:0006654
GO:0055114
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|
phosphatidic acid biosynthetic process
oxidation reduction
|
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GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0560
|
|
P  
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete


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*  
*  
****************************************************************************************** -->{{Product_interactions_help}}
****************************************************************************************** -->{{Product_interactions_help}}
{|   id="G46aa61e1d3c21"  class=" tableEdit Product_interactions_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="G46aa61e1d3c21"  class=" tableEdit Product_interactions_table dataTable"   
|-
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-  
|-  
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Experiment(s):EBI-893265<br />  
Experiment(s):EBI-893265<br />  
|-
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Protein
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rraB
|
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PMID:19402753
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LCMS(ID Probability):99.6
|-
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Protein
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dnaN
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PMID:19402753
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MALDI(Z-score):36.876428
|-
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Protein
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yfgI
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PMID:19402753
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MALDI(Z-score):17.053160


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****************************************************************************************** -->{{Product_localization_help}}
****************************************************************************************** -->{{Product_localization_help}}
{|   id="I46a7f4be28cd7"  class=" tableEdit Product_localization_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="I46a7f4be28cd7"  class=" tableEdit Product_localization_table"   
|-
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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****************************************************************************************** -->{{Product_physical_properties_help}}
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{| id="Y46aa61e3a62f6"  class=" tableEdit Product_phys_prop_table"   
{|   id="Y46aa61e3a62f6"  class=" tableEdit Product_phys_prop_table"   
 
|-
!align=left {{table heading style}} |Name
||


|-
|-
!align=left |Sequence
!align=left {{table heading style}} |Sequence
||
||
[http://biocyc.org/ECOLI/sequence-aa?object=ENOYL-ACP-REDUCT-NADH-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=ENOYL-ACP-REDUCT-NADH-MONOMER at EcoCyc]  
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SGEVVHVDGG FSIAAMNELE LK</pre>  
SGEVVHVDGG FSIAAMNELE LK</pre>  
|-
|-
!align=left |Length
!align=left {{table heading style}} |Length
||
||
262
262
|-
|-
!align=left |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
27.864 kDa
27.864 kDa
|-
|-
!align=left |pI
!align=left {{table heading style}} |pI
||
||
5.7 (calculated)
5.7 (calculated)
|-
|-
!align=left |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
15,930 - 16,430 (calc based on 7 Y, 1 W, and 4 C residues)
15,930 - 16,430 (calc based on 7 Y, 1 W, and 4 C residues)
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*  
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****************************************************************************************** -->{{Product_domains_motifs_help}}
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{|   id="L46aa61e40f64f"  class=" tableEdit Product_motif_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="L46aa61e40f64f"  class=" tableEdit Product_motif_table dataTable"   
|-
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-  
|-  
|
|
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Removed
Removed
|
|
[http://www.uniprot.org/uniprot/P0AEK4#section_features UniProt:P0AEK4]  
[http://www.uniprot.org/uniprot/P0AEK4#section_features UniProt:P0AEK4]
|
|-
|
Domain
|
7..178
|
[http://pfam.janelia.org/family/PF00106 PF00106  short chain dehydrogenase]
|
 
|
PMID:19920124


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|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22550.L46aa61e40f64f&page=22550&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
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****************************************************************************************** -->{{Product_structure_help}}
{| id="K46aa61e45cf18"  class=" tableEdit Product_structure_table"   
{|   id="K46aa61e45cf18"  class=" tableEdit Product_structure_table"   


|-
|-
!align=left |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>
<beststructure>
Line 617: Line 762:
</beststructure>
</beststructure>
|-
|-
!align=left |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0AEK4 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0AEK4 PSI-PRED (P0AEK4)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0AEK4 Genomes TO Protein (P0AEK4)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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****************************************************************************************** -->{{Product_resources_help}}
****************************************************************************************** -->{{Product_resources_help}}
{|   id="S46aa61e926c4e"  class=" tableEdit Product_resource_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="S46aa61e926c4e"  class=" tableEdit Product_resource_table"   
|-
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference


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*  
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****************************************************************************************** -->{{Gene_accessions_help}}
****************************************************************************************** -->{{Gene_accessions_help}}
{|   id="Z46aa61e975468"  class=" tableEdit Gene_accessions_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="Z46aa61e975468"  class=" tableEdit Gene_accessions_table"   
|-
|- {{table_heading_style}}
!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-  
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16129249 GI:16129249]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415804.1 GeneID:945870]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0004327
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0AEK4 UniProtKB/Swiss-Prot:P0AEK4]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[EcoCyc]]
|
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=ENOYL-ACP-REDUCT-NADH-MONOMER EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER]
EcoCyc:EG11528
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
[[EcoGene]]
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[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0AEK4 SwissModel:P0AEK4]
EcoGene:EG11528
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
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[[uniprot:P0AEK4|UniProt:P0AEK4]]
[http://www.ncbi.nlm.nih.gov/gene?term=945870 GeneID:945870]
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Escherichia coli str. K-12 substr. MG1655
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
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[http://pfam.sanger.ac.uk/family?acc=PF00106 PFAM:PF00106]
RegulonDB:ECK120001482
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415804 RefSeq:NP_415804]
EchoBASE:EB1490
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0006654_!_phosphatidic acid biosynthetic process]][[Category:Products with structures in PDB]]

Latest revision as of 20:37, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabI

Synonyms

enoyl-[acyl-carrier-protein] reductase, NADH-dependent[1], B1288[2][1], Gts[2][1], QmeA[2][1], EnvM[2][1], FabI[2][1] , ECK1283, envM, gts, JW1281, qmeA, b1288

Product description

ENOYL-ACP-REDUCT-NADH[2][3]

Enoyl-ACP reductase, NADH dependent[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

F

Seeded from EcoCyc (v14.0)

complete

GO:0004318

enoyl-(acyl-carrier-protein) reductase (NADH) activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014358

F

Seeded from EcoCyc (v14.0)

complete

GO:0004318

enoyl-(acyl-carrier-protein) reductase (NADH) activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.3.1.9

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014358

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002198

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002347

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

P

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002198

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002347

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc (v14.0)

complete

GO:0019898

extrinsic to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9903

C

Seeded from EcoCyc (v14.0)

complete

GO:0046677

response to antibiotic

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0046

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002347

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014358

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

yfgI

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

dnaN

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rho

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rplJ

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rpsA

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rpsJ

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

ycbY

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

yjgD

PMID:15690043[6]

Experiment(s):EBI-893265

Protein

rraB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

dnaN

PMID:19402753[7]

MALDI(Z-score):36.876428

Protein

yfgI

PMID:19402753[7]

MALDI(Z-score):17.053160

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MGFLSGKRIL VTGVASKLSI AYGIAQAMHR EGAELAFTYQ NDKLKGRVEE FAAQLGSDIV
LQCDVAEDAS IDTMFAELGK VWPKFDGFVH SIGFAPGDQL DGDYVNAVTR EGFKIAHDIS
SYSFVAMAKA CRSMLNPGSA LLTLSYLGAE RAIPNYNVMG LAKASLEANV RYMANAMGPE
GVRVNAISAG PIRTLAASGI KDFRKMLAHC EAVTPIRRTV TIEDVGNSAA FLCSDLSAGI
SGEVVHVDGG FSIAAMNELE LK
Length

262

Mol. Wt

27.864 kDa

pI

5.7 (calculated)

Extinction coefficient

15,930 - 16,430 (calc based on 7 Y, 1 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0AEK4

Domain

7..178

PF00106 short chain dehydrogenase

PMID:19920124[8]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fabI taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129249

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945870

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004327

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AEK4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11528

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11528

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945870

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001482

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1490

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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