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<noinclude>{{TabsTop}}   
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{{Tab On|Quickview|kefA}}{{Tab|Gene|kefA}}{{Tab|Gene Product(s)|kefA}}{{Tab|Expression|kefA}}{{Tab|Evolution|kefA}}{{Tab|On One Page|kefA}}{{TabsBottom}}
{{Tab On|Quickview|kefA}}{{Tab|Gene|kefA}}{{Tab|Gene Product(s)|kefA}}{{Tab|Expression|kefA}}{{Tab|Evolution|kefA}}{{Tab|On One Page|kefA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[kefA:Gene|''kefA]]'' (synonyms: ''ECK0459, b0465, JW0454, aefA, mscK'')<ref name='LIB:Riley_2006'/>
''kefA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[kefA:Gene_Product(s)|KefA product]]<ref name='LIB:Riley_2006'/>: fused conserved protein product, mechanosensitive channel protein product, B0465 product, MscK product, AefA product
''ECK0459, b0465, JW0454, aefA, mscK''<ref name='LIB:Riley_2006'/>, mscK, pnuH''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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KefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
KefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Mechanosensitive channel protein, intermediate conductance; regulation of ion balance and turgor pressure at high osmolarity; also may affect activity of mechanosensitive channel MscS<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''fused conserved protein<ref name='LIB:Riley_2006'/>, mechanosensitive channel protein<ref name='LIB:Riley_2006'/>, B0465<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MscK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, KefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , aefA, ECK0459, JW0454, mscK, pnuH, b0465''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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|-
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:kefA|kefA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:kefA|kefA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=kefA&s=search]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=kefA&loc=MG1655%3A485760..489122,W3110%3A485760..489122,DH10B%3A425091..428453,REL606%3A458603..461965,BW2952%3A388519..391881]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=388519&end=391881&gene=kefA&aa=mtmfqyykrsrhfvfsafiafvfvllcqntafarassngdlptkadlqaqldslnkqkdlsaqdklvqqdltdtlatldkidrikeetvqlrqkvaeapekmrqataaltalsdvdndeetrkilstlslrqletrvaqalddlqnaqndlasynsqlvslqtqpervqnamynasqqlqqirsrldgtdvgetalrpsqkvlmqaqqallnaeidqqrkslegntvlqdtlqkqrdyvtansarlehqlqllqeavnskrltltektaqeavspdeaariqanplvkqeleinqqlsqrlitatengnqlmqqnikvknwleralqsernikeqiavlkgslllsrilyqqqqtlpsadelenmtnriadlrleqfevnqqrdalfqsdafvnkleeghtnevnsevhdallqvvdmrrelldqlnkqlgnqlmmainlqinqqqlmsvsknlksiltqqifwvnsnrpmdwdwikafpqslkdefksmkitvnwqkawpavfiaflaglpllliaglihwrlgwlkayqqklasavgslrndsqlntpkailidliralpvcliilavglilltmqlnisellwsfskklaifwlvfglcwkvlekngvavrhfgmpeqqtshwrrqivrislallpihfwsvvaelsplhlmddvlgqamiffnllliaflvwpmcreswrdkeshtmrlvtitvlsiipialmvltatgyfyttlrlagrwietvylviiwnllyqtvlrglsvaarriawrralarrqnlvkegaegaeppeeptialeqvnqqtlritmllmfalfgvmfwaiwsdlitvfsyldsitlwhyngteagaavvknvtmgsllfaiiasmvawalirnlpgllevlvlsrlnmrqgasyaittilnyiiiavgamtvfgslgvswdklqwlaaalsvglgfglqeifgnfvsgliilferpvrigdtvtigsfsgtvskirirattitdfdrkeviipnkafvterlinwsltdtttrlvirlgvaygsdlekvrkvllkaatehprvmhepmpevfftafgastldhelrlyvrelrdrsrtvdelnrtidqlcrendiniafnqlevhlhnekgdevtevkrdykgddptpavg]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=kefA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=kefA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Consistently co-purifies with the degradosome. Probable false positive lipoprotein prediction, 12 CM TMs, Cys not conserved. First 33 aa are predicted to be a type I signal peptide; the first 40 aa enable export of a fusion protein into the periplasm (McLaggan, 2002). mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

kefA

Gene Synonym(s)

ECK0459, b0465, JW0454, aefA, mscK[1], mscK, pnuH

Product Desc.

KefA[2][3]

Mechanosensitive channel protein, intermediate conductance; regulation of ion balance and turgor pressure at high osmolarity; also may affect activity of mechanosensitive channel MscS[4]

Product Synonyms(s)

fused conserved protein[1], mechanosensitive channel protein[1], B0465[2][1], MscK[2][1], KefA[2][1], AefA[2][1] , aefA, ECK0459, JW0454, mscK, pnuH, b0465

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): kefA[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Consistently co-purifies with the degradosome. Probable false positive lipoprotein prediction, 12 CM TMs, Cys not conserved. First 33 aa are predicted to be a type I signal peptide; the first 40 aa enable export of a fusion protein into the periplasm (McLaggan, 2002). mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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