mrcB:Gene Product(s): Difference between revisions

Standard name	MrcB
Synonyms	fused glycosyl transferase^[1], transpeptidase^[1], B0149^[2]^[1], PonB^[2]^[1], PbpF^[2]^[1], MrcB^[2]^[1], PBP1B^[2]^[1] , ECK0148, JW0145, pbpF, ponB, b0149
Product description	MrcB^[2]^[3]; Component of penicillin-binding protein 1B^[3] Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric^[4]
EC number (for enzymes)	2.4.1.129^[1] 3.4.-.-^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane				C	Seeded from Riley et al 2006 ^[1].	Missing: evidence, reference
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0008955	peptidoglycan glycosyltransferase activity	PMID:6389538^[5]	IDA: Inferred from Direct Assay		F		complete
	GO:0051518	positive regulation of bipolar cell growth	PMID:330236^[6]	IDA: Inferred from Direct Assay		P	Cephaloridine has a high affinity for PBP1B. When this happens, cell elongation is inhibited, causing the cell to lyse.	complete
	GO:0009002	serine-type D-Ala-D-Ala carboxypeptidase activity	PMID:6389538^[5]	IDA: Inferred from Direct Assay		F		complete
	GO:0008658	penicillin binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001460	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008955	peptidoglycan glycosyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011813	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008955	peptidoglycan glycosyltransferase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.4.1.129	F	Seeded from EcoCyc (v14.0)	complete
	GO:0009252	peptidoglycan biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001264	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009252	peptidoglycan biosynthetic process	PMID:16569861^[7]	IMP: Inferred from Mutant Phenotype		P	Table 1 shows a PBP1B deficient strain produce lipid II instead of peptidoglycan.	complete
	GO:0009252	peptidoglycan biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0573	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009274	peptidoglycan-based cell wall	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001264	C	Seeded from EcoCyc (v14.0)	complete
	GO:0009274	peptidoglycan-based cell wall	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011813	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	PMID:16858726^[8]	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9906	C	Seeded from EcoCyc (v14.0)	complete
	GO:0046677	response to antibiotic	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011813	P	Seeded from EcoCyc (v14.0)	complete
	GO:0046677	response to antibiotic	PMID:371539^[9]	IDA: Inferred from Direct Assay	SP_KW:KW-0046	P	Table 1 shows Cephalosporin Beta-Lactams exhibit high affinity for PBP1B.	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of penicillin-binding protein 1B	could be indirect
Protein	talB		PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	hupA		PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	hemB		PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	ppsA		PMID:19402753^[10]	LCMS(ID Probability):99.6
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
plasma membrane
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MAGNDREPIG RKGKPTRPVK QKVSRRRYED DDDYDDYDDY EDEEPMPRKG KGKGKGRKPR GKRGWLWLLL KLAIVFAVLI AIYGVYLDQK IRSRIDGKVW QLPAAVYGRM VNLEPDMTIS KNEMVKLLEA TQYRQVSKMT RPGEFTVQAN SIEMIRRPFD FPDSKEGQVR ARLTFDGDHL ATIVNMENNR QFGFFRLDPR LITMISSPNG EQRLFVPRSG FPDLLVDTLL ATEDRHFYEH DGISLYSIGR AVLANLTAGR TVQGASTLTQ QLVKNLFLSS ERSYWRKANE AYMALIMDAR YSKDRILELY MNEVYLGQSG DNEIRGFPLA SLYYFGRPVE ELSLDQQALL VGMVKGASIY NPWRNPKLAL ERRNLVLRLL QQQQIIDQEL YDMLSARPLG VQPRGGVISP QPAFMQLVRQ ELQAKLGDKV KDLSGVKIFT TFDSVAQDAA EKAAVEGIPA LKKQRKLSDL ETAIVVVDRF SGEVRAMVGG SEPQFAGYNR AMQARRSIGS LAKPATYLTA LSQPKIYRLN TWIADAPIAL RQPNGQVWSP QNDDRRYSES GRVMLVDALT RSMNVPTVNL GMALGLPAVT ETWIKLGVPK DQLHPVPAML LGALNLTPIE VAQAFQTIAS GGNRAPLSAL RSVIAEDGKV LYQSFPQAER AVPAQAAYLT LWTMQQVVQR GTGRQLGAKY PNLHLAGKTG TTNNNVDTWF AGIDGSTVTI TWVGRDNNQP TKLYGASGAM SIYQRYLANQ TPTPLNLVPP EDIADMGVDY DGNFVCSGGM RILPVWTSDP QSLCQQSEMQ QQPSGNPFDQ SSQPQQQPQQ QPAQQEQKDS DGVAGWIKDM FGSN
Length	844
Mol. Wt	94.294 kDa
pI	9.5 (calculated)
Extinction coefficient	116,200 - 116,450 (calc based on 30 Y, 13 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	472..744	PF00905 Penicillin binding protein transpeptidase domain	PMID:19920124^[11]
Domain	198..381	PF00912 Transglycosylase	PMID:19920124^[11]
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mrcB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128142	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:944843	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000516	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P02919	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10605	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10605	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:944843	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000598	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0600	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 Nakagawa, J et al. (1984) Functional biosynthesis of cell wall peptidoglycan by polymorphic bifunctional polypeptides. Penicillin-binding protein 1Bs of Escherichia coli with activities of transglycosylase and transpeptidase. J. Biol. Chem. 259 13937-46 PubMed
↑ Spratt, BG & Jobanputra, V (1977) Mutants of Escherichia coli which lack a component of penicillin-binding protein 1 are viable. FEBS Lett. 79 374-8 PubMed
↑ Ramachandran, V et al. (2006) Screen for inhibitors of the coupled transglycosylase-transpeptidase of peptidoglycan biosynthesis in Escherichia coli. Antimicrob. Agents Chemother. 50 1425-32 PubMed
↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
↑ Nozaki, Y et al. (1979) SCE-963, a new potent cephalosporin with high affinity for penicillin-binding proteins 1 and 3 of Escherichia coli. Antimicrob. Agents Chemother. 15 20-7 PubMed
↑ ^10.0 ^10.1 ^10.2 ^10.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
↑ ^11.0 ^11.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

mrcB:Gene Product(s): Difference between revisions

Latest revision as of 20:21, 17 February 2015

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

@@ Line 35: / Line 35: @@
 *
 ****************************************************************************************** -->{{Product_nomenclature_help}}
-{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{|   id="I46aa1f4c96902"  class=" tableEdit Product_nomenclature_table"
 |-
@@ Line 44: / Line 44: @@
 !align=left {{table heading style}} |Synonyms
 ||
-fused glycosyl transferase<ref name='LIB:Riley_2006'/>, transpeptidase<ref name='LIB:Riley_2006'/>, B0149<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PbpF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1B<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
+''fused glycosyl transferase<ref name='LIB:Riley_2006'/>, transpeptidase<ref name='LIB:Riley_2006'/>, B0149<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PbpF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1B<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0148, JW0145, pbpF, ponB, b0149''
 |-
 !align=left {{table heading style}} |Product description
@@ Line 59: / Line 59: @@
 * [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.-.- 3.4.-.-]<ref name='LIB:Riley_2006'/>
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.I46aa1f4c96902&page=19829&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.I46aa1f4c96902&page=19829&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table]</span> ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.I46aa1f4c96902-->
@@ Line 78: / Line 78: @@
 *
 ****************************************************************************************** -->{{Product_GO_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" {{Prettytable}}
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="V46aa1f4e062de"  class=" tableEdit GO_table_product dataTable"
 |- {{table_heading_style}}
-!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
+!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
 |-
 |
 |
-GO:0005624
+GO:0005887
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-membrane fraction
+integral to plasma membrane
 |
-PMID:16858726
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-IDA: Inferred from Direct Assay
 |
@@ Line 97: / Line 97: @@
 C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
 |
-complete
+Missing: evidence, reference
 |-
 |
 |
-GO:0003824
+GO:0005886
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-catalytic activity
+plasma membrane
 |
-GO_REF:0000002<br />GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR001264<br />SP_KW:KW-0511
+SP_KW:KW-0997
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-F
+C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 123: / Line 123: @@
 |
-GO:0007047
+GO:0005886
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-cell wall organization
+plasma membrane
 |
-GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
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 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0961
+SP_KW:KW-1003
 |
-P
+C
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 142: / Line 142: @@
 |
-GO:0008233
+GO:0008955
 |
-peptidase activity
+peptidoglycan glycosyltransferase activity
 |
-GO_REF:0000002
+PMID:6389538
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-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-InterPro:IPR011813
 |
 F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
 |
 complete
@@ Line 161: / Line 161: @@
 |
-GO:0008360
+GO:0051518
 |
-regulation of cell shape
+positive regulation of bipolar cell growth
 |
-GO_REF:0000004
+PMID:330236
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-SP_KW:KW-0133
 |
 P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Cephaloridine has a high affinity for PBP1B. When this happens, cell elongation is inhibited, causing the cell to lyse.
 |
 complete
@@ Line 180: / Line 180: @@
 |
-GO:0008658
+GO:0009002
 |
-penicillin binding
+serine-type D-Ala-D-Ala carboxypeptidase activity
 |
-GO_REF:0000002
+PMID:6389538
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-InterPro:IPR001460
 |
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 |
 complete
@@ Line 199: / Line 199: @@
 |
-GO:0008955
+GO:0008658
 |
-peptidoglycan glycosyltransferase activity
+penicillin binding
 |
-GO_REF:0000002<br />GO_REF:0000003
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR011813<br />EC:2.4.1.129
+InterPro:IPR001460
 |
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 218: / Line 218: @@
 |
-GO:0009252
+GO:0008955
 |
-peptidoglycan biosynthetic process
+peptidoglycan glycosyltransferase activity
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR001264<br />InterPro:IPR011813<br />SP_KW:KW-0573
+InterPro:IPR011813
 |
-P
+F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 237: / Line 237: @@
 |
-GO:0009273
+GO:0008955
 |
-peptidoglycan-based cell wall biogenesis
+peptidoglycan glycosyltransferase activity
 |
-GO_REF:0000002
+GOA:spec<br />GO_REF:0000003
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR001460
+EC:2.4.1.129
 |
-P
+F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 256: / Line 256: @@
 |
-GO:0009274
+GO:0009252
 |
-peptidoglycan-based cell wall
+peptidoglycan biosynthetic process
 |
-GO_REF:0000002<br />GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR001264<br />InterPro:IPR011813
+InterPro:IPR001264
 |
-C
+P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 275: / Line 275: @@
 |
-GO:0016020
+GO:0009252
 |
-membrane
+peptidoglycan biosynthetic process
 |
-GO_REF:0000004<br />GO_REF:0000004
+PMID:16569861
 |
-IEA: Inferred from Electronic Annotation
+IMP: Inferred from Mutant Phenotype
 |
-SP_KW:KW-0397<br />SP_KW:KW-0472
 |
-C
+P
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Table 1 shows a PBP1B deficient strain produce lipid II instead of peptidoglycan.
 |
 complete
@@ Line 294: / Line 294: @@
 |
-GO:0016021
+GO:0009252
 |
-integral to membrane
+peptidoglycan biosynthetic process
 |
-GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0812
+SP_KW:KW-0573
 |
-C
+P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 313: / Line 313: @@
 |
-GO:0016740
+GO:0009274
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-transferase activity
+peptidoglycan-based cell wall
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-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0808
+InterPro:IPR001264
 |
-F
+C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 332: / Line 332: @@
 |
-GO:0016757
+GO:0009274
 |
-transferase activity, transferring glycosyl groups
+peptidoglycan-based cell wall
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0328
+InterPro:IPR011813
 |
-F
+C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 351: / Line 351: @@
 |
-GO:0016787
+GO:0016020
 |
-hydrolase activity
+membrane
 |
-GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0378
+SP_KW:KW-0472
 |
-F
+C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 370: / Line 370: @@
 |
-GO:0046677
+GO:0016020
 |
-response to antibiotic
+membrane
 |
-GO_REF:0000002<br />GO_REF:0000004
+PMID:16858726
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-InterPro:IPR011813<br />SP_KW:KW-0046
 |
-P
+C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 389: / Line 389: @@
 |
-GO:0005887
+GO:0016021
 |
-integral to plasma membrane
+integral to membrane
 |
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
+IEA: Inferred from Electronic Annotation
 |
+SP_KW:KW-0812
 |
 C
 |
-Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
+Seeded from [[EcoCyc]] (v14.0)
 |
-required field missing
+complete
 |-
 |
 |
-GO:0005739
+GO:0016021
 |
-mitochondrion
+integral to membrane
 |
-PMID:16858726
+GO_REF:0000023
 |
-IDA: Inferred from Direct Assay
+IEA: Inferred from Electronic Annotation
 |
+SP_SL:SL-9906
 |
 C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 427: / Line 427: @@
 |
-GO:0005886
+GO:0046677
 |
-plasma membrane
+response to antibiotic
 |
-GO_REF:0000004<br />GO_REF:0000004<br />GO_REF:0000023
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0997<br />SP_KW:KW-1003<br />SP_SL:SL-0037
+InterPro:IPR011813
 |
-C
+P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 446: / Line 446: @@
 |
-GO:0008144
+GO:0046677
 |
-drug binding
+response to antibiotic
 |
-PMID:10564478<br />PMID:11933234<br />PMID:12325012<br />PMID:365089<br />PMID:371539<br />PMID:6268122<br />PMID:6373702<br />PMID:6376452<br />PMID:6427167<br />PMID:6448021<br />PMID:6448573<br />PMID:6941742<br />PMID:7018389<br />PMID:7049076
+PMID:371539
 |
 IDA: Inferred from Direct Assay
 |
-<br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br />
+SP_KW:KW-0046
 |
-F
+P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Table 1 shows Cephalosporin Beta-Lactams exhibit high affinity for PBP1B.
 |
 complete
+|- class="tableEdit_footer"
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.V46aa1f4e062de&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</span> || || || || || || || ||
+|}
+<!--box uid=421aa90e079fa326b6494f812ad13e79.19829.V46aa1f4e062de-->
+<span id="Interactions"></span><big>'''Interactions'''</big>
+<!--box uid=421aa90e079fa326b6494f812ad13e79.19829.G46aa1f68a11ad-->
+<!--
+******************************************************************************************
+*
+*   ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
+*
+****************************************************************************************** -->{{Product_interactions_help}}
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="G46aa1f68a11ad"  class=" tableEdit Product_interactions_table dataTable"
+|- {{table heading style}}
+!|Partner Type!!Partner!!Notes!!References!!Evidence
 |-
 |
+Protein
 |
-GO:0046349
+Subunits of [[:Category:Complex:penicillin-binding protein 1B|penicillin-binding protein 1B]]
 |
-amino sugar biosynthetic process
+could be indirect
 |
 |
-|
-|
-P
-|
-Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
-|
-required fields missing
 |-
 |
+Protein
 |
-GO:0042493
+talB
 |
-response to drug
-|
-|
-|
-|
-P
 |
-Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
+PMID:19402753
 |
-required fields missing
+LCMS(ID Probability):99.6
 |-
 |
+Protein
-|
-GO:0000910
 |
-cytokinesis
+hupA
-|
-|
-|
-|
-P
-|
-Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
-|
-required fields missing
-|-
 |
 |
-GO:0008955
+PMID:19402753
-|
-peptidoglycan glycosyltransferase activity
-|
-PMID:6389538
 |
-IDA: Inferred from Direct Assay
+LCMS(ID Probability):99.6
-|
-|
-F
-|
-|
-complete
 |-
 |
+Protein
-|
-GO:0009002
-|
-serine-type D-Ala-D-Ala carboxypeptidase activity
 |
-PMID:6389538
+hemB
-|
-IDA: Inferred from Direct Assay
 |
 |
-F
+PMID:19402753
 |
+LCMS(ID Probability):99.6
-|
-complete
-|-class='sortbottom'
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.V46aa1f4e062de&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
-|}
-<!--box uid=421aa90e079fa326b6494f812ad13e79.19829.V46aa1f4e062de-->
-<span id="Interactions"></span><big>'''Interactions'''</big>
-<!--box uid=421aa90e079fa326b6494f812ad13e79.19829.G46aa1f68a11ad-->
-<!--
-******************************************************************************************
-*
-*   ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
-*
-****************************************************************************************** -->{{Product_interactions_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
-|- {{table heading style}}
-!|Partner Type!!Partner!!Notes!!References!!Evidence
 |-
 |
 Protein
 |
-Subunits of [[:Category:Complex:penicillin-binding protein 1B|penicillin-binding protein 1B]]
+ppsA
 |
-could be indirect
 |
+PMID:19402753
 |
+LCMS(ID Probability):99.6
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.G46aa1f68a11ad&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.G46aa1f68a11ad&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table]</span> || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.G46aa1f68a11ad-->
@@ Line 602: / Line 553: @@
 *
 ****************************************************************************************** -->{{Product_localization_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="Y46aa1f69a8b79"  class=" tableEdit Product_localization_table"
 |- {{table heading style}}
-!|Compartment!!Description!!Evidence!!Notes
+!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
 |-
 |
@@ Line 613: / Line 564: @@
 |
+|
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.Y46aa1f69a8b79&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.Y46aa1f69a8b79&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table]</span> || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.Y46aa1f69a8b79-->
@@ Line 636: / Line 589: @@
 *
 ****************************************************************************************** -->{{Product_physical_properties_help}}
-{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{|   id="B46aa1f6b19333"  class=" tableEdit Product_phys_prop_table"
+|-
+!align=left {{table heading style}} |Name
+||
 |-
@@ Line 673: / Line 630: @@
 ,200 - 116,450 (calc based on 30 Y, 13 W, and 2 C residues)
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.B46aa1f6b19333&page=19829&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.B46aa1f6b19333&page=19829&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table]</span> ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.B46aa1f6b19333-->
@@ Line 688: / Line 645: @@
 *
 ****************************************************************************************** -->{{Product_domains_motifs_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="S46aa1f6b71a1f"  class=" tableEdit Product_motif_table dataTable"
 |- {{table heading style}}
-!|Type!!Residues!!Description!!Notes
+!|Type!!Residues!!Description!!Notes!!References
+|-
+|
+Domain
+|
+..744
+|
+[http://pfam.janelia.org/family/PF00905 PF00905  Penicillin binding protein transpeptidase domain]
+|
+|
+PMID:19920124
+|-
+|
+Domain
+|
+..381
+|
+[http://pfam.janelia.org/family/PF00912 PF00912  Transglycosylase]
+|
+|
+PMID:19920124
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.S46aa1f6b71a1f&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.S46aa1f6b71a1f&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.S46aa1f6b71a1f--></td>
@@ Line 713: / Line 692: @@
 *
 ****************************************************************************************** -->{{Product_structure_help}}
-{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{|   id="Y46a7b09e4a0fc"  class=" tableEdit Product_structure_table"
 |-
@@ Line 726: / Line 705: @@
 ||
 View models at:
-* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
+* [http://www.proteinmodelportal.org/query/uniprot/P02919 Protein Model Portal]
-* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
+* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P02919 PSI-PRED (P02919)]
-* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
+* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P02919 Genomes TO Protein (P02919)] (GTOP)
-* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
-* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.Y46a7b09e4a0fc&page=19829&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.Y46a7b09e4a0fc&page=19829&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table]</span> ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.Y46a7b09e4a0fc-->
@@ Line 771: / Line 748: @@
 *
 ****************************************************************************************** -->{{Product_resources_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="O46aa1f6c107a9"  class=" tableEdit Product_resource_table"
 |- {{table_heading_style}}
 !|Resource type!!Source!!Notes/Reference
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.O46aa1f6c107a9&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.O46aa1f6c107a9&page=19829&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table]</span> || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.O46aa1f6c107a9-->
@@ Line 793: / Line 770: @@
 *
 ****************************************************************************************** -->{{Gene_accessions_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="R46aa1f6c5a367"  class=" tableEdit Gene_accessions_table"
 |- {{table_heading_style}}
 !|Database!!Accession!!Notes
 |-
 |
-[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
+[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
+|
+[http://www.ncbi.nlm.nih.gov/protein/16128142 GI:16128142]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
+|
+[http://www.ncbi.nlm.nih.gov/protein/NP_414691.1 GeneID:944843]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[[ASAP]]
+|
+ASAP:ABE-0000516
+|
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
+|-
+|
+[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
+|
+[http://www.uniprot.org/uniprot/P02919 UniProtKB/Swiss-Prot:P02919]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[[EcoCyc]]
 |
-[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10605-MONOMER EcoCyc:EG10605-MONOMER]
+EcoCyc:EG10605
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
+[[EcoGene]]
 |
-[[uniprot:P02919|UniProt:P02919]]
+EcoGene:EG10605
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
+[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
 |
-[http://pfam.sanger.ac.uk/family?acc=PF00912 PFAM:PF00912]
+[http://www.ncbi.nlm.nih.gov/gene?term=944843 GeneID:944843]
 |
+Escherichia coli str. K-12 substr. MG1655
 |-
 |
-[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
+[[RegulonDB]]
 |
-[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414691 RefSeq:NP_414691]
+RegulonDB:ECK120000598
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://BioCyc.org/ECOO157/ ECOO157CYC] ([[ECOO157CYC|EcoliWiki Page]])
+[[EchoBASE]]
 |
-[http://BioCyc.org/ECOO157/new-image?object=MRCB-MONOMER ECOO157CYC:MRCB-MONOMER]
+EchoBASE:EB0600
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.R46aa1f6c5a367&page=19829&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.R46aa1f6c5a367&page=19829&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table]</span> || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.R46aa1f6c5a367-->
@@ Line 850: / Line 855: @@
 *
 ****************************************************************************************** -->
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="O46a7b0a2788f5"  class=" tableEdit Links_table"
 |- {{table_heading_style}}
 !|Name!!URL!!Comments
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.O46a7b0a2788f5&page=19829&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19829.O46a7b0a2788f5&page=19829&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table]</span> || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.19829.O46a7b0a2788f5-->
@@ Line 871: / Line 876: @@
 {{BacktoTop}}
 [[Category:Proteins]]
-[[Category:GO:0031225_!_anchored to membrane]][[Category:GO:0046349_!_amino sugar biosynthetic process]][[Category:GO:0009252_!_peptidoglycan biosynthetic process]][[Category:GO:0042493_!_response to drug]][[Category:GO:0000910_!_cytokinesis]][[Category:Complex:penicillin-binding protein 1B]][[Category:Location:plasma membrane]]

mrcB:Gene Product(s): Difference between revisions

Latest revision as of 20:21, 17 February 2015

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

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