Phage lambda cII:Gene Product(s): Difference between revisions

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|-
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!align=left {{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
||
||
cII  
cII
|-
|-
!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
cII, lambdap59  
cII, lambdap59
|-
|-
!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
||
||
activator  of Pre and Pi  
activator  of Pre and Pi
|-
|-
!align=left {{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0019044
|
maintenance of viral latency
|
PMID:9324241
|
IMP: Inferred from Mutant Phenotype
|
 
|
P
|
 
|
complete
|-
|
 
|
GO:0019043
|
establishment of viral latency
|
PMID:12397182
|
IMP: Inferred from Mutant Phenotype
|
 
|
P
|
 
|
complete
|-
|
 
|
GO:0045893
|
positive regulation of transcription, DNA-dependent
|
PMID:2931430
|
IDA: Inferred from Direct Assay
|
 
|
P
|


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complete
 
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{{Product_GO_help}}


<span id="Interactions"></span><big>'''Interactions'''</big>
<span id="Interactions"></span><big>'''Interactions '''</big>
<protect><!--box uid=bc145ea147f7e36caf09c1bfeed4ee9d.104241.V4a848f74c87e6-->
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!|Partner Type!!Partner!!Notes!!References!!Evidence
 
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{{Product_interactions_help}}
 
<!--Function_notes--></protect>
<!--Function_notes-->
===Notes===
===Notes===


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!|Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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|-
!align=left {{table heading style}} |Name
||


|-
|-
!align=left {{table heading style}} |Sequence
!align=left {{table heading style}} |Sequence
||
||
<pre>MVRANKRNEA LRIESALLNK IAMLGTEKTA EAVGVDKSQI SRWKRDWIPK FSMLLAVLEW
<pre>MVRANKRNEA LRIESALLNK IAMLGTEKTA EAVGVDKSQI SRWKRDWIPK FSMLLAVLEW
GVVDDDMARL ARQVAAILTN KKRPAATERS EQIQMEF</pre>  
GVVDDDMARL ARQVAAILTN KKRPAATERS EQIQMEF</pre>
|-
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!align=left {{table heading style}} |Length
!align=left {{table heading style}} |Length
||
||
11.06 kDa (calc) 
97
|-
|-
!align=left {{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
11.055 kDa
|-
|-
!align=left {{table heading style}} |pI
!align=left {{table heading style}} |pI
||
||
10.1 (calculated)
|-
|-
!align=left {{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
16,500 (calc based on 0 Y, 3 W, and 0 C residues)


 
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</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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|-
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!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=Phage_lambda_cII
taxon=10710
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
View models at:
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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</td><td></protect>
==== Structure figures ====
{{File:1ZPQ.pdb}}
{{File:1ZS4.pdb}}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===
 
See ''Crystal structure of bacteriophage lambda cII and its DNA complex''<ref name='PMID:16039594'/> , [http://www.rcsb.org/pdb/explore/explore.do?structureId=1ZPQ| PDB 1ZPQ (protein alone)], or [http://www.rcsb.org/pdb/explore/explore.do?structureId=1ZS4| PDB 1ZS4 (protein/DNA complex)].


==Gene Product Resources==
==Gene Product Resources==
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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene Genbank] ([[Genbank|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/sites/entrez?db=protein&cmd=&term=NP_040630.1 Genbank:NP_040630.1]
|


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{{BacktoTop}}
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<references/>
<references />
__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:FtsH substrates]]

Latest revision as of 20:19, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

cII

Synonyms

cII, lambdap59

Product description

activator of Pre and Pi

EC number (for enzymes)


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See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Notes

Function

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Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0019044

maintenance of viral latency

PMID:9324241[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0019043

establishment of viral latency

PMID:12397182[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:2931430[3]

IDA: Inferred from Direct Assay

P

complete

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See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Interactions

<protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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See Help:Product_localization for how to add or edit information in this section of EcoliWiki.


Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MVRANKRNEA LRIESALLNK IAMLGTEKTA EAVGVDKSQI SRWKRDWIPK FSMLLAVLEW
GVVDDDMARL ARQVAAILTN KKRPAATERS EQIQMEF
Length

97

Mol. Wt

11.055 kDa

pI

10.1 (calculated)

Extinction coefficient

16,500 (calc based on 0 Y, 3 W, and 0 C residues)

edit table

See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
edit table
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=Phage_lambda_cII taxon=10710 </beststructure>

Models

View models at:

edit table

See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structure figures

See Help:Jmol in EcoliWiki

Biological assembly of cII protein, PDB:1ZPQ
<jmol> <jmolApplet> <color>white</color> <uploadedFileContents >1ZPQ.pdb</uploadedFileContents> <name></name> <script> wireframe off; spacefill off; trace off; rotate ON; cartoon; color chain; </script> </jmolApplet> </jmol>
<jmol> <jmolCheckbox > <scriptWhenChecked > rotate on; </scriptWhenChecked > <scriptWhenUnchecked > rotate off; </scriptWhenUnchecked > <checked>true</checked> <text>rotate</text> </jmolCheckbox > <jmolButton><script>reset; </script><text>reset</text></jmolButton> </jmol>

See Help:Jmol in EcoliWiki

cII Protein/DNA complex: biological function. PDB:1ZS4l
<jmol> <jmolApplet> <color>white</color> <uploadedFileContents >1ZS4.pdb</uploadedFileContents> <name></name> <script> wireframe off; spacefill off; trace off; rotate ON; cartoon; color chain; </script> </jmolApplet> </jmol>
<jmol> <jmolCheckbox > <scriptWhenChecked > rotate on; </scriptWhenChecked > <scriptWhenUnchecked > rotate off; </scriptWhenUnchecked > <checked>true</checked> <text>rotate</text> </jmolCheckbox > <jmolButton><script>reset; </script><text>reset</text></jmolButton> </jmol>








Notes

See Crystal structure of bacteriophage lambda cII and its DNA complex[4] , PDB 1ZPQ (protein alone), or PDB 1ZS4 (protein/DNA complex).

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ Obuchowski, M et al. (1997) Stability of CII is a key element in the cold stress response of bacteriophage lambda infection. J. Bacteriol. 179 5987-91 PubMed
  2. ↑ Kobiler, O et al. (2002) The phage lambda CII transcriptional activator carries a C-terminal domain signaling for rapid proteolysis. Proc. Natl. Acad. Sci. U.S.A. 99 14964-9 PubMed
  3. ↑ Ho, YS & Rosenberg, M (1985) Characterization of a third, cII-dependent, coordinately activated promoter on phage lambda involved in lysogenic development. J. Biol. Chem. 260 11838-44 PubMed
  4. ↑ Jain, D et al. (2005) Crystal structure of bacteriophage lambda cII and its DNA complex. Mol. Cell 19 259-69 PubMed

Categories

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