flgM:Gene Product(s): Difference between revisions

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!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
anti-sigma factor for FliA (sigma 28)<ref name='LIB:Riley_2006'/>, B1071<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FlgM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''anti-sigma factor for FliA (sigma 28)<ref name='LIB:Riley_2006'/>, B1071<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FlgM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1056, JW1058, mviS, b1071''
|-
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!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
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anti-sigma factor for FliA (sigma 28)<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
anti-sigma factor for FliA (sigma 28)<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Anti-sigma 28 (FliA) factor; regulator of FlhD<ref name='LIB:EcoGene'/>
|-
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!align=left {{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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*


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<protect><!--Nomenclature_notes--></protect>
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===Notes===
===Notes===
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{{BacktoTop}}
{{BacktoTop}}
<protect>
<protect>
<big>'''Gene Ontology'''</big><br />{{Product_GO_help}}<!--box uid=421aa90e079fa326b6494f812ad13e79.22036.P46aa546f184a8-->
<big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.22036.P46aa546f184a8-->
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="P46aa546f184a8"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
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!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-  
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[[Category:GO:0019861_!_flagellum]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0019861_!_flagellum GO:0019861]
GO:0006350
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|
flagellum
transcription
|
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]<br />[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
GOA:spkw<br />SP_KW:GO_REF:0000004
|
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR007412 InterPro:IPR007412]<br />[http://www.uniprot.org/keywords/KW-0282 SP_KW:KW-0282]
SP_KW:KW-0804
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|
C
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
|
 
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[[Category:GO:0016564_!_transcription_repressor_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016564_!_transcription_repressor_activity GO:0016564]
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transcription repressor activity
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]
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IEA: Inferred from Electronic Annotation
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[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR007412 InterPro:IPR007412]
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|
F
Seeded from [[EcoCyc]] (v14.0)
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete  
complete  
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[[Category:GO:0016481_!_negative_regulation_of_transcription]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016481_!_negative_regulation_of_transcription GO:0016481]
GO:0016481
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negative regulation of transcription
negative regulation of transcription
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR007412 InterPro:IPR007412]
InterPro:IPR007412
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P
P
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|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
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complete  
complete  
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[[Category:GO:0006355_!_regulation_of_transcription,_DNA-dependent]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006355_!_regulation_of_transcription,_DNA-dependent GO:0006355]
GO:0016564
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|
regulation of transcription, DNA-dependent
transcription repressor activity
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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[http://www.uniprot.org/keywords/KW-0805 SP_KW:KW-0805]
InterPro:IPR007412
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P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
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complete  
complete  
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|
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[[Category:GO:0006350_!_transcription]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006350_!_transcription GO:0006350]
GO:0019861
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transcription
flagellum
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
[http://www.uniprot.org/keywords/KW-0804 SP_KW:KW-0804]
InterPro:IPR007412
|
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P
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
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complete  
complete  
|-
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[[Category:GO:0042330_!_taxis]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0042330_!_taxis GO:0042330]
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taxis
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|
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P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
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required fields missing 
|-
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[[Category:GO:0005737_!_cytoplasm]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005737_!_cytoplasm GO:0005737]
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cytoplasm
|
|
|
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C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing 
|-
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[[Category:GO:0016989_!_sigma_factor_antagonist_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016989_!_sigma_factor_antagonist_activity GO:0016989]
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sigma factor antagonist activity
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|
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F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing 


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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
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Protein
Protein
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[[fliA:Gene_Product(s)|fliA]]<br />
fliA<br />
|
|


|[[PMID:16606699]]<ref name=PMID:16606699/>
|
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Experiment(s):[http://www.ebi.ac.uk/iintact/search/do/search?searchString=EBI-1138760 EBI-1138760]<br />  
PMID:16606699
|
Experiment(s):EBI-1138760<br />  
|-  
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Protein
Protein
|
|
[[gltX:Gene_Product(s)|gltX]]<br />
gltX<br />
|
|


|[[PMID:16606699]]<ref name=PMID:16606699/>
|
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Experiment(s):[http://www.ebi.ac.uk/iintact/search/do/search?searchString=EBI-1138760 EBI-1138760]<br />  
PMID:16606699
|
Experiment(s):EBI-1138760<br />  
|-  
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Protein
Protein
|
|
[[yahG:Gene_Product(s)|yahG]]<br />
yahG<br />
|
|


|[[PMID:16606699]]<ref name=PMID:16606699/>
|
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Experiment(s):[http://www.ebi.ac.uk/iintact/search/do/search?searchString=EBI-1138760 EBI-1138760]<br />  
PMID:16606699
|
Experiment(s):EBI-1138760<br />  
|-  
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Protein
Protein
|
|
[[tatE:Gene_Product(s)|tatE]]<br />
tatE<br />
|
|


|[[PMID:16606699]]<ref name=PMID:16606699/>
|
|
Experiment(s):[http://www.ebi.ac.uk/iintact/search/do/search?searchString=EBI-1138760 EBI-1138760]<br />  
PMID:16606699
|
Experiment(s):EBI-1138760<br />  
|-  
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Protein
Protein
|
|
[[pepD:Gene_Product(s)|pepD]]<br />
pepD<br />
|
|


|[[PMID:16606699]]<ref name=PMID:16606699/>
|
|
Experiment(s):[http://www.ebi.ac.uk/iintact/search/do/search?searchString=EBI-1138760 EBI-1138760]<br />  
PMID:16606699
|
Experiment(s):EBI-1138760<br />  
|-  
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Protein
Protein
|
|
[[dnaK:Gene_Product(s)|dnaK]]<br />
dnaK<br />
|
|


|[[PMID:16606699]]<ref name=PMID:16606699/>
|
|
Experiment(s):[http://www.ebi.ac.uk/iintact/search/do/search?searchString=EBI-1138760 EBI-1138760]<br />  
PMID:16606699
|
Experiment(s):EBI-1138760<br />  


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===Notes===
===Notes===
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!|Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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!align=left {{table heading style}} |Name
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<pre>MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
<pre>MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN</pre>  
ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN</pre>  
|-
!align=left {{table heading style}} |Length
||
97
|-
|-
!align=left {{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
10.34 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
10.34 kDa
|-
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!align=left {{table heading style}} |pI
!align=left {{table heading style}} |pI
||
||
5.2 (calculated)
|-
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!align=left {{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
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0 (calc based on 0 Y, 0 W, and 0 C residues)  
0 (calc based on 0 Y, 0 W, and 0 C residues)


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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span>
 
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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
<tr align="left" valign="top">
<td><!--box uid=421aa90e079fa326b6494f812ad13e79.22036.S46aa5487c48eb-->
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!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
25..90
|
[http://pfam.janelia.org/family/PF04316 PF04316  Anti-sigma-28 factor, FlgM]
|


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PMID:19920124
 
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{{Product_domains_motifs_help}}
<td>
<!-- motifs column 2-->
<motif_map/>
</td>
</tr>
</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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|-
|-
!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>flgM
<beststructure>
562</beststructure>
gene=flgM
 
taxon=562,83333
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=flgM&sub=keywordSearc EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0AEM4 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=flgM&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0AEM4 PSI-PRED (P0AEM4)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0AEM4 Genomes TO Protein (P0AEM4)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===
 
FlgM is an intrinsically disordered protein in vitro.  In vivo, there is evidence that it gains structure<ref name='PMID: 12271132'/>.


==Gene Product Resources==
==Gene Product Resources==
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16129034 GI:16129034]
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G369-MONOMER EcoCyc:G369-MONOMER]
Escherichia coli str. K-12 substr. MG1655
|-  
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[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415589.1 GeneID:946684]
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Escherichia coli str. K-12 substr. MG1655
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[[ASAP]]
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ASAP:ABE-0003634
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.uniprot.org/uniprot/P0AEM4 UniProtKB/Swiss-Prot:P0AEM4]
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Escherichia coli str. K-12 substr. MG1655
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[[EcoCyc]]
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EcoCyc:G369
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[[EcoGene]]
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EcoGene:EG12664
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
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[[uniprot:P0AEM4|UniProt:P0AEM4]]
[http://www.ncbi.nlm.nih.gov/gene?term=946684 GeneID:946684]
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Escherichia coli str. K-12 substr. MG1655
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
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[http://pfam.sanger.ac.uk/family?acc=PF04316 PFAM:PF04316]
RegulonDB:ECK120002689
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415589 RefSeq:NP_415589]
EchoBASE:EB2530
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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__NOTOC__
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</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0042330_!_taxis]][[Category:GO:0006350_!_transcription]][[Category:GO:0005737_!_cytoplasm]][[Category:GO:0019861_!_flagellum]][[Category:GO:0016989_!_sigma factor antagonist activity]]

Latest revision as of 20:34, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FlgM

Synonyms

anti-sigma factor for FliA (sigma 28)[1], B1071[2][1], FlgM[2][1] , ECK1056, JW1058, mviS, b1071

Product description

anti-sigma factor for FliA (sigma 28)[2][3]

Anti-sigma 28 (FliA) factor; regulator of FlhD[4]

EC number (for enzymes)


edit table


Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0016481

negative regulation of transcription

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007412

P

Seeded from EcoCyc (v14.0)

complete

GO:0016564

transcription repressor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007412

F

Seeded from EcoCyc (v14.0)

complete

GO:0019861

flagellum

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007412

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

fliA

PMID:16606699[5]

Experiment(s):EBI-1138760

Protein

gltX

PMID:16606699[5]

Experiment(s):EBI-1138760

Protein

yahG

PMID:16606699[5]

Experiment(s):EBI-1138760

Protein

tatE

PMID:16606699[5]

Experiment(s):EBI-1138760

Protein

pepD

PMID:16606699[5]

Experiment(s):EBI-1138760

Protein

dnaK

PMID:16606699[5]

Experiment(s):EBI-1138760
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
Length

97

Mol. Wt

10.34 kDa

pI

5.2 (calculated)

Extinction coefficient

0 (calc based on 0 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

25..90

PF04316 Anti-sigma-28 factor, FlgM

PMID:19920124[6]

edit table

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=flgM taxon=562,83333 </beststructure>

Models

View models at:

edit table

Structure figures

Notes

FlgM is an intrinsically disordered protein in vitro. In vivo, there is evidence that it gains structure[7].

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129034

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946684

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003634

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AEM4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G369

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12664

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946684

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002689

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2530

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
  7. ↑ Dedmon, MM et al. (2002) FlgM gains structure in living cells. Proc. Natl. Acad. Sci. U.S.A. 99 12681-4 PubMed

Categories

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