fabI:Gene Product(s): Difference between revisions

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|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Gene Product Resources|Resources]]
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{|{{Prettytable}}
{|  id="N46aa61d7b3c6e"  class=" tableEdit Product_nomenclature_table" 
 
|-
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!{{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
|
||
FabI product
FabI  
|-
|-
!{{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
|
||
enoyl-[acyl-carrier-protein] reductase, NADH-dependent product<ref name='LIB:Riley_2006'/>, B1288 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Gts product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, QmeA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EnvM product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FabI product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''enoyl-[acyl-carrier-protein] reductase, NADH-dependent<ref name='LIB:Riley_2006'/>, B1288<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Gts<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, QmeA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EnvM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FabI<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1283, envM, gts, JW1281, qmeA, b1288''
|-
|-
!{{table heading style}} |Product description
!align=left {{table heading style}} |Product description
|
||
ENOYL-ACP-REDUCT-NADH-MONOMER<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
ENOYL-ACP-REDUCT-NADH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Enoyl-ACP reductase, NADH dependent<ref name='LIB:EcoGene'/>
|-
|-
!{{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
|
||
** [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]<ref name='LIB:Riley_2006'/>
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]<ref name='LIB:Riley_2006'/>
|-
 
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===Notes===
===Notes===
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{{BacktoTop}}
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<protect>
<protect>
<big>'''Gene Ontology'''</big><br />{{Product_GO_help}}<!--box uid=421aa90e079fa326b6494f812ad13e79.22550.O46aa61d8c0fe1-->
<big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.22550.O46aa61d8c0fe1-->
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{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="O46aa61d8c0fe1"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0003824
|
catalytic activity
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0004318_!_enoyl-(acyl-carrier-protein)_reductase_(NADH)_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0004318_!_enoyl-(acyl-carrier-protein)_reductase_(NADH)_activity GO:0004318]
GO:0004318
|
|
enoyl-(acyl-carrier-protein) reductase (NADH) activity
enoyl-(acyl-carrier-protein) reductase (NADH) activity
|
|
GO_REF:0000003
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
EC:1.3.1.9
InterPro:IPR014358
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 97: Line 120:


|
|
[[Category:GO:0005515_!_protein_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005515_!_protein_binding GO:0005515]
GO:0004318
|
|
protein binding
enoyl-(acyl-carrier-protein) reductase (NADH) activity
|
|
[[PMID:15690043]]<ref name=PMID:15690043/>
GOA:spec<br />GO_REF:0000003
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0AF90
EC:1.3.1.9
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 116: Line 139:


|
|
[[Category:GO:0005624_!_membrane_fraction]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005624_!_membrane_fraction GO:0005624]
GO:0005886
|
plasma membrane
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
membrane fraction
IEA: Inferred from Electronic Annotation
|
|
[[PMID:16858726]]<ref name=PMID:16858726/>
SP_KW:KW-0997
|
|
IDA: Inferred from Direct Assay
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
|


|
GO:0005886
|
plasma membrane
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
|
C
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0006633
|
fatty acid biosynthetic process
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR014358
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
[[Category:GO:0006633_!_fatty_acid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006633_!_fatty_acid_biosynthetic_process GO:0006633]
GO:0006633
|
|
fatty acid biosynthetic process
fatty acid biosynthetic process
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 147: Line 208:
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 154: Line 215:


|
|
[[Category:GO:0008152_!_metabolic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008152_!_metabolic_process GO:0008152]
GO:0008152
|
|
metabolic process
metabolic process
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 166: Line 227:
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 173: Line 234:


|
|
[[Category:GO:0008152_!_metabolic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008152_!_metabolic_process GO:0008152]
GO:0008152
|
|
metabolic process
metabolic process
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 185: Line 246:
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 192: Line 253:


|
|
[[Category:GO:0008610_!_lipid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008610_!_lipid_biosynthetic_process GO:0008610]
GO:0008152
|
metabolic process
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0008610
|
|
lipid biosynthetic process
lipid biosynthetic process
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 204: Line 284:
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 211: Line 291:


|
|
[[Category:GO:0016020_!_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016020_!_membrane GO:0016020]
GO:0016020
|
|
membrane
membrane
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0397
SP_KW:KW-0472
|
|
C
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 230: Line 310:


|
|
[[Category:GO:0016020_!_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016020_!_membrane GO:0016020]
GO:0016020
|
|
membrane
membrane
|
|
GO_REF:0000004
PMID:16858726
|
|
IEA: Inferred from Electronic Annotation
IDA: Inferred from Direct Assay
|
|
SP_KW:KW-0472
 
|
|
C
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 249: Line 329:


|
|
[[Category:GO:0016491_!_oxidoreductase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016491_!_oxidoreductase_activity GO:0016491]
GO:0016491
|
|
oxidoreductase activity
oxidoreductase activity
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 261: Line 341:
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 268: Line 348:


|
|
[[Category:GO:0016491_!_oxidoreductase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016491_!_oxidoreductase_activity GO:0016491]
GO:0016491
|
|
oxidoreductase activity
oxidoreductase activity
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 280: Line 360:
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 287: Line 367:


|
|
[[Category:GO:0016491_!_oxidoreductase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016491_!_oxidoreductase_activity GO:0016491]
GO:0016491
|
|
oxidoreductase activity
oxidoreductase activity
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 299: Line 379:
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0019898
|
extrinsic to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9903
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0046677
|
response to antibiotic
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0046
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
|
[[Category:GO:0005737_!_cytoplasm]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005737_!_cytoplasm GO:0005737]
GO:0055114
|
|
cytoplasm
oxidation reduction
|
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR002347
|
|
C
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|
 
|
|
[[Category:GO:0006654_!_phosphatidic_acid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006654_!_phosphatidic_acid_biosynthetic_process GO:0006654]
GO:0055114
|
|
phosphatidic acid biosynthetic process
oxidation reduction
|
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR014358
|
|
P  
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
[[Category:GO:0046677_!_response_to_antibiotic]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0046677_!_response_to_antibiotic GO:0046677]
GO:0055114
|
|
response to antibiotic
oxidation reduction
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0046
SP_KW:KW-0560
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  


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!Partner Type!!Partner!!Notes
!|Partner Type!!Partner!!Notes!!References!!Evidence
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Protein
|
yfgI<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
dnaN<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
rho<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
rplJ<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
rpsA<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
rpsJ<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
ycbY<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-887392<br />
|-
|
Protein
|
yjgD<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-893265<br />
|-
|
Protein
|
rraB
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
dnaN
|
 
|
PMID:19402753
|
MALDI(Z-score):36.876428
|-
|
Protein
|
yfgI
|
 
|
PMID:19402753
|
MALDI(Z-score):17.053160
 
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===Notes===
===Notes===
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!Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
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{|{{Prettytable}}
{|   id="Y46aa61e3a62f6"  class=" tableEdit Product_phys_prop_table" 
 
|-
!align=left {{table heading style}} |Name
||
 
|-
|-
!{{table heading style}} |Sequence
!align=left {{table heading style}} |Sequence
|
||
[http://biocyc.org/ECOLI/sequence-aa?object=ENOYL-ACP-REDUCT-NADH-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=ENOYL-ACP-REDUCT-NADH-MONOMER at EcoCyc]  
<pre>MGFLSGKRIL VTGVASKLSI AYGIAQAMHR EGAELAFTYQ NDKLKGRVEE FAAQLGSDIV
<pre>MGFLSGKRIL VTGVASKLSI AYGIAQAMHR EGAELAFTYQ NDKLKGRVEE FAAQLGSDIV
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SGEVVHVDGG FSIAAMNELE LK</pre>  
SGEVVHVDGG FSIAAMNELE LK</pre>  
|-
|-
!{{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Length
|
||
27.86 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
262
|-
|-
!{{table heading style}} |pI
!align=left {{table heading style}} |Mol. Wt
|
||
5.88<ref name='LIB:EcoCyc10.6'/>
27.864 kDa
|-
|-
!{{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |pI
|
||
15930 - 16430 (calc based on 7 Y, 1 W, and 4 C residues)  
5.7 (calculated)
|-
|-
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!align=left {{table heading style}} |Extinction coefficient
||
15,930 - 16,430 (calc based on 7 Y, 1 W, and 4 C residues)
 
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<big>'''Domains/Motifs/Modification Sites'''</big>
 
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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
<tr align="left" valign="top">
<td><!--box uid=421aa90e079fa326b6494f812ad13e79.22550.L46aa61e40f64f-->
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|- {{table heading style}}
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-class='sortbottom'
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|
Initiator Methionine
|
1
|
Removed
|
[http://www.uniprot.org/uniprot/P0AEK4#section_features UniProt:P0AEK4]
|
|-
|
Domain
|
7..178
|
[http://pfam.janelia.org/family/PF00106 PF00106  short chain dehydrogenase]
|
 
|
PMID:19920124
 
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{{Product_domains_motifs_help}}
<td>
<!-- motifs column 2-->
<motif_map/>
</td>
</tr>
</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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{|   id="K46aa61e45cf18" class=" tableEdit Product_structure_table"


|-
|-
!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>fabI
<beststructure>
562</beststructure>
gene=fabI
 
taxon=562,83333
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=fabI&sub=keywordSearc EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0AEK4 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=fabI&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0AEK4 PSI-PRED (P0AEK4)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0AEK4 Genomes TO Protein (P0AEK4)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===


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===Notes===
===Notes===
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|- {{table_heading_style}}
|- {{table_heading_style}}
!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16129249 GI:16129249]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415804.1 GeneID:945870]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0004327
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=ENOYL-ACP-REDUCT-NADH-MONOMER EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER]
[http://www.uniprot.org/uniprot/P0AEK4 UniProtKB/Swiss-Prot:P0AEK4]
|
|
Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
[[EcoCyc]]
|
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0AEK4 SwissModel:P0AEK4] 
EcoCyc:EG11528
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
[[EcoGene]]
|
|
[[uniprot:P0AEK4|UniProt:P0AEK4]] 
EcoGene:EG11528
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[http://pfam.sanger.ac.uk/family?acc=PF00106 PFAM:PF00106]
[http://www.ncbi.nlm.nih.gov/gene?term=945870 GeneID:945870]
|
|
Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415804 RefSeq:NP_415804] 
RegulonDB:ECK120001482
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1DFG PDB:1DFG] 
EchoBASE:EB1490
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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{{BacktoTop}}
{{BacktoTop}}
{{RefHelp}}
{{RefHelp}}
<references/>
<references />
__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0006654_!_phosphatidic acid biosynthetic process]][[Category:Products with structures in PDB]]

Latest revision as of 20:37, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabI

Synonyms

enoyl-[acyl-carrier-protein] reductase, NADH-dependent[1], B1288[2][1], Gts[2][1], QmeA[2][1], EnvM[2][1], FabI[2][1] , ECK1283, envM, gts, JW1281, qmeA, b1288

Product description

ENOYL-ACP-REDUCT-NADH[2][3]

Enoyl-ACP reductase, NADH dependent[4]

EC number (for enzymes)
edit table


Notes

Function

[back to top]


Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

F

Seeded from EcoCyc (v14.0)

complete

GO:0004318

enoyl-(acyl-carrier-protein) reductase (NADH) activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014358

F

Seeded from EcoCyc (v14.0)

complete

GO:0004318

enoyl-(acyl-carrier-protein) reductase (NADH) activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.3.1.9

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014358

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002198

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002347

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

P

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002198

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002347

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc (v14.0)

complete

GO:0019898

extrinsic to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9903

C

Seeded from EcoCyc (v14.0)

complete

GO:0046677

response to antibiotic

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0046

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002347

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014358

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

yfgI

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

dnaN

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rho

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rplJ

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rpsA

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

rpsJ

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

ycbY

PMID:15690043[6]

Experiment(s):EBI-887392

Protein

yjgD

PMID:15690043[6]

Experiment(s):EBI-893265

Protein

rraB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

dnaN

PMID:19402753[7]

MALDI(Z-score):36.876428

Protein

yfgI

PMID:19402753[7]

MALDI(Z-score):17.053160

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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MGFLSGKRIL VTGVASKLSI AYGIAQAMHR EGAELAFTYQ NDKLKGRVEE FAAQLGSDIV
LQCDVAEDAS IDTMFAELGK VWPKFDGFVH SIGFAPGDQL DGDYVNAVTR EGFKIAHDIS
SYSFVAMAKA CRSMLNPGSA LLTLSYLGAE RAIPNYNVMG LAKASLEANV RYMANAMGPE
GVRVNAISAG PIRTLAASGI KDFRKMLAHC EAVTPIRRTV TIEDVGNSAA FLCSDLSAGI
SGEVVHVDGG FSIAAMNELE LK
Length

262

Mol. Wt

27.864 kDa

pI

5.7 (calculated)

Extinction coefficient

15,930 - 16,430 (calc based on 7 Y, 1 W, and 4 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0AEK4

Domain

7..178

PF00106 short chain dehydrogenase

PMID:19920124[8]

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<motif_map/>

Structure
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Structures

<beststructure> gene=fabI taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129249

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945870

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004327

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AEK4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11528

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11528

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945870

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001482

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1490

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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