msbA:Gene Product(s): Difference between revisions
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|{{Sub}}[[#Localization |Localization]] | |{{Sub}}[[#Localization |Localization]] | ||
|{{Sub}}[[#Sequence|Sequence]] | |{{Sub}}[[#Sequence|Sequence]] | ||
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]] | |||
|{{Sub}}[[#Structure|Structure]] | |{{Sub}}[[#Structure|Structure]] | ||
|{{Sub}}[[#Gene Product Resources|Resources]] | |{{Sub}}[[#Gene Product Resources|Resources]] | ||
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{| id="S46aa4b46a0d97" class=" tableEdit Product_nomenclature_table" | |||
|- | |- | ||
!{{table heading style}} |Standard name | !align=left {{table heading style}} |Standard name | ||
| | || | ||
MsbA | MsbA | ||
|- | |- | ||
!{{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
| | || | ||
fused lipid transporter subunits of ABC superfamily: membrane component | ''fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ECK0905, JW0897, b0914'' | ||
|- | |- | ||
!{{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
| | || | ||
ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | ||
Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/> | |||
|- | |- | ||
!{{table heading style}} |EC number (for enzymes) | !align=left {{table heading style}} |EC number (for enzymes) | ||
| | || | ||
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<protect><!--Nomenclature_notes--></protect> | <protect><!--Nomenclature_notes--></protect> | ||
===Notes=== | ===Notes=== | ||
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{{BacktoTop}} | {{BacktoTop}} | ||
<protect> | <protect> | ||
<big>'''Gene Ontology'''</big> | <big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.21674.B46aa4b479d593--> | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="B46aa4b479d593" class=" tableEdit GO_table_product dataTable" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Qualifier!!GO ID!!GO term name!!Reference | !|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005515 | |||
| | | | ||
protein binding | |||
| | | | ||
PMID:18344567 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | |||
| | | | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0034040 | |||
| | | | ||
lipid-transporting ATPase activity | |||
| | | | ||
PMID:18344567 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | |||
| | | | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005524 | |||
| | | | ||
ATP binding | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0067 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005886 | |||
| | | | ||
membrane | plasma membrane | ||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0997 | ||
| | | | ||
C | C | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005886 | |||
| | | | ||
membrane | plasma membrane | ||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-1003 | ||
| | | | ||
C | C | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0006869 | |||
| | | | ||
lipid transport | |||
| | | | ||
GOA:hamap<br />GO_REF:0000020 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
HAMAP:MF_01703 | |||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0006869 | |||
| | | | ||
lipid transport | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR011917 | ||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0006869 | |||
| | | | ||
lipid transport | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| Line 243: | Line 227: | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016020 | |||
| | | | ||
membrane | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0472 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016020 | |||
| | | | ||
membrane | |||
| | | | ||
PMID:16858726 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR001140 | ||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0812 | ||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0008289 | |||
| | | | ||
lipid binding | |||
| | | | ||
PMID:18344567 | |||
| | | | ||
IDA: Inferred from Direct Assay | IDA: Inferred from Direct Assay | ||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR011917 | ||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0812 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GO_REF:0000023 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_SL:SL-9909 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0055085 | |||
| | | | ||
transmembrane transport | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR001140 | |||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0055085 | |||
| | | | ||
transmembrane transport | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR011527 | ||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005319 | |||
| | | | ||
lipid transporter activity | |||
| | | | ||
GOA:hamap<br />GO_REF:0000020 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
HAMAP:MF_01703 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005524 | |||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR001140 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005524 | |||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR003439 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005524 | |||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR011527 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005524 | |||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR011917 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005524 | |||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR017871 | |||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|-class= | |- class="tableEdit_footer" | ||
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21674.B46aa4b479d593&page=21674&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || || | |<div class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21674.B46aa4b479d593&page=21674&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</div> || || || || || || || || | ||
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<span id="Interactions"></span><big>'''Interactions'''</big> | <span id="Interactions"></span><big>'''Interactions'''</big> | ||
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|- {{table heading style}} | |- {{table heading style}} | ||
!Partner Type!!Partner!!Notes | !|Partner Type!!Partner!!Notes!!References!!Evidence | ||
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===Notes=== | ===Notes=== | ||
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|- {{table heading style}} | |- {{table heading style}} | ||
!Compartment!!Description!!Evidence!!Notes | !|Compartment!!Description!!Evidence!!Reference/Source!!Notes | ||
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plasma membrane | |||
| | |||
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains | |||
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Daley et al. (2005) <ref name=PMID:15919996/> | |||
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{|{{ | {| id="W46aa4b49d4e91" class=" tableEdit Product_phys_prop_table" | ||
|- | |||
!align=left {{table heading style}} |Name | |||
|| | |||
|- | |- | ||
!{{table heading style}} |Sequence | !align=left {{table heading style}} |Sequence | ||
| | || | ||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10613-MONOMER at EcoCyc] | [http://biocyc.org/ECOLI/sequence-aa?object=EG10613-MONOMER at EcoCyc] | ||
<pre>MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD | <pre>MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD | ||
| Line 642: | Line 624: | ||
LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL | LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL | ||
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS | LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS | ||
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ</pre> | TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ</pre> | ||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |Length | ||
| | || | ||
582 | |||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |Mol. Wt | ||
| | || | ||
64.462 kDa | |||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |pI | ||
| | || | ||
8.8 (calculated) | |||
|- | |- | ||
| | !align=left {{table heading style}} |Extinction coefficient | ||
|| | |||
46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues) | |||
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|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21674.W46aa4b49d4e91&page=21674&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table]</span> || | |||
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<big>'''Domains/Motifs/Modification Sites'''</big> | |||
<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span> | |||
<table> | |||
<tr align="left" valign="top"> | |||
<td> | |||
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|- {{table heading style}} | |- {{table heading style}} | ||
!Type!!Residues!!Description!!Notes | !|Type!!Residues!!Description!!Notes!!References | ||
|-class= | |- | ||
|[{{SERVER}}{{SCRIPTPATH}} | | | ||
Domain | |||
| | |||
24..298 | |||
| | |||
[http://pfam.janelia.org/family/PF00664 PF00664 ABC transporter transmembrane region] | |||
| | |||
| | |||
PMID:19920124 | |||
|- | |||
| | |||
Domain | |||
| | |||
383..509 | |||
| | |||
[http://pfam.janelia.org/family/PF00005 PF00005 ABC transporter] | |||
| | |||
| | |||
PMID:19920124 | |||
|- class="tableEdit_footer" | |||
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<!-- motifs column 2--> | |||
<motif_map/> | |||
{{TMHMM Picture|msbA}} | |||
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<table><tr valign='top'><td> | |||
<span id='Structure'></span><big>'''Structure'''</big><br /> | |||
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|- | |||
|-class= | !align=left {{table heading style}} |Structures | ||
|[{{SERVER}}{{SCRIPTPATH}} | || | ||
<beststructure> | |||
gene=msbA | |||
taxon=562,83333 | |||
</beststructure> | |||
|- | |||
!align=left {{table heading style}} |Models | |||
|| | |||
View models at: | |||
* [http://www.proteinmodelportal.org/query/uniprot/P60752 Protein Model Portal] | |||
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P60752 PSI-PRED (P60752)] | |||
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P60752 Genomes TO Protein (P60752)] (GTOP) | |||
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==== Structure figures ==== | |||
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===Notes=== | ===Notes=== | ||
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!Database!!Accession!!Notes | !|Database!!Accession!!Notes | ||
|- | |- | ||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/16128881 GI:16128881] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/NP_415434.1 GeneID:945530] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[[ASAP]] | |||
| | |||
ASAP:ABE-0003113 | |||
| | |||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |||
| | |||
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | |||
| | |||
[http://www.uniprot.org/uniprot/P60752 UniProtKB/Swiss-Prot:P60752] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | | | ||
[[EcoCyc]] | |||
| | | | ||
EcoCyc:EG10613 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EcoGene]] | |||
| | | | ||
EcoGene:EG10613 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]]) | ||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/gene?term=945530 GeneID:945530] | ||
| | | | ||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |- | ||
| | | | ||
[[RegulonDB]] | |||
| | | | ||
RegulonDB:ECK120000606 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EchoBASE]] | |||
| | | | ||
EchoBASE:EB0608 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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{{RefHelp}} | {{RefHelp}} | ||
<references/> | <references /> | ||
__NOTOC__ | __NOTOC__ | ||
===Categories=== | ===Categories=== | ||
{{BacktoTop}} | {{BacktoTop}} | ||
[[Category:Proteins]] | |||
[[Category:RefGenome_Annotated_Gene]] | |||
[[Category:Pfam:PF00664_!_ABC transporter transmembrane region]] | |||
[[Category:Pfam:PF00005_!_ABC transporter]] | |||
[[Category:RefGenome_Annotated_Gene]] | |||
Latest revision as of 20:54, 6 July 2021
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
MsbA |
|---|---|
| Synonyms |
fused lipid transporter subunits of ABC superfamily: membrane component[1], ATP-binding component[1], B0914[2][1], MsbA[2][1], ECK0905, JW0897, b0914 |
| Product description |
ATP-binding transport protein[2][3] Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase[4] |
| EC number (for enzymes) |
|
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0034040 |
lipid-transporting ATPase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0005524 |
ATP binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006869 |
lipid transport |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006869 |
lipid transport |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006869 |
lipid transport |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0016021 |
integral to membrane |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008289 |
lipid binding |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0016021 |
integral to membrane |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-9909 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0055085 |
transmembrane transport |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0055085 |
transmembrane transport |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005319 |
lipid transporter activity |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
|
plasma membrane |
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains |
Daley et al. (2005) [7] |
| |
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD RSVLVWMPLV VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI AIRVVSKRFR NISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT YPGRDVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ |
| Length |
582 |
| Mol. Wt |
64.462 kDa |
| pI |
8.8 (calculated) |
| Extinction coefficient |
46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 Eckford, PD & Sharom, FJ (2008) Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. J. Biol. Chem. 283 12840-50 PubMed
- ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
- ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
- ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0005515 ! protein binding
- GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity
- GO:0005524 ! ATP binding
- GO:0005886 ! plasma membrane
- GO:0006869 ! lipid transport
- GO:0016020 ! membrane
- GO:0016021 ! integral component of membrane
- GO:0008289 ! lipid binding
- GO:0055085 ! transmembrane transport
- GO:0005319 ! lipid transporter activity
- TMHMM Prediction
- Proteins
- RefGenome Annotated Gene
- Pfam:PF00664 ! ABC transporter transmembrane region
- Pfam:PF00005 ! ABC transporter
