Genes not mapped to a genome sequence: Difference between revisions
Table edited by JimHu via TableEdit |
Table edited by Joncrz via TableEdit |
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This page has a list of genes that are described in the 1998 linkage map for E. coli K-12 (Edition 10)<ref name='PMID:9729611'/> but have not been correlated with a gene in EcoliWiki. In most cases, the alleles that led to assignment of these gene names are likely to affect known genes, but which gene has not been determined. | This page has a list of genes that are described in the 1998 linkage map for E. coli K-12 (Edition 10)<ref name='PMID:9729611'/> but have not been correlated with a gene in EcoliWiki. In most cases, the alleles that led to assignment of these gene names are likely to affect known genes, but which gene has not been determined. | ||
Further information about a particular gene may be found on the EcoliWiki page for the publication(s) describing the mutants. Click on the PMID: link to access that page. | |||
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{| | {| id="F48dd6c8083174" class=" tableEdit " | ||
|- | |- | ||
!|Gene!!Approx. Map Location!!Mnemonic!!Notes!!Candidate gene(s) | !|Gene!!Approx. Map Location!!Mnemonic!!Paper(s) describing gene!!Notes!!Candidate gene(s) | ||
|- | |- | ||
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| Line 18: | Line 20: | ||
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Arg binding protein | Arg binding protein | ||
| | |||
| | | | ||
Low-affinity transport system for arginine and ornithine; periplasmic binding protein [[cgsc_site:18562|CGSC]] | Low-affinity transport system for arginine and ornithine; periplasmic binding protein [[cgsc_site:18562|CGSC]] | ||
| Line 29: | Line 33: | ||
| | | | ||
Antibiotic sensitivity | Antibiotic sensitivity | ||
| | |||
| | | | ||
Sensitivity and permeability to antibiotics and dyes [[cgsc_site:18559|CGSC]] | Sensitivity and permeability to antibiotics and dyes [[cgsc_site:18559|CGSC]] | ||
| Line 40: | Line 46: | ||
| | | | ||
Acyl carrier protein | Acyl carrier protein | ||
| | |||
| | | | ||
acpS; originally thought to be holo-ACP synthase; perhaps cryptic second gene or regulator [[cgsc_site:1046|CGSC]] | acpS; originally thought to be holo-ACP synthase; perhaps cryptic second gene or regulator [[cgsc_site:1046|CGSC]] | ||
| Line 51: | Line 59: | ||
| | | | ||
Acridine | Acridine | ||
| | |||
| | | | ||
Sensitivity to acriflavine; transmembrane protein [[cgsc_site:1044|CGSC]] | Sensitivity to acriflavine; transmembrane protein [[cgsc_site:1044|CGSC]] | ||
| Line 62: | Line 72: | ||
| | | | ||
Alcohol dehydrogenase | Alcohol dehydrogenase | ||
| | |||
| | | | ||
Alcohol dehydrogenase [[cgsc_site:36932|CGSC]] | Alcohol dehydrogenase [[cgsc_site:36932|CGSC]] | ||
| Line 73: | Line 85: | ||
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Acetylgalactosamine | Acetylgalactosamine | ||
| | |||
| | | | ||
Cluster of putative N-acetylgalactosamine pathway genes, including the kba gene, and mannose permease homologs [[cgsc_site:55305|CGSC]] | Cluster of putative N-acetylgalactosamine pathway genes, including the kba gene, and mannose permease homologs [[cgsc_site:55305|CGSC]] | ||
| Line 84: | Line 98: | ||
| | | | ||
Aromatic | Aromatic | ||
| | |||
| | | | ||
Function unknown [[cgsc_site:1000|CGSC]] | Function unknown [[cgsc_site:1000|CGSC]] | ||
| Line 95: | Line 111: | ||
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Azaserine | Azaserine | ||
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| | | | ||
Mutants azaserine resistant [[cgsc_site:970|CGSC]] | Mutants azaserine resistant [[cgsc_site:970|CGSC]] | ||
| Line 106: | Line 124: | ||
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Azaserine | Azaserine | ||
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| | | | ||
Mutants azaserine resistant [[cgsc_site:969|CGSC]] | Mutants azaserine resistant [[cgsc_site:969|CGSC]] | ||
| Line 117: | Line 137: | ||
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Azaleucine | Azaleucine | ||
| | |||
| | | | ||
Mutants azaleucine resistant; regulates ilv and leu [[cgsc_site:967|CGSC]] | Mutants azaleucine resistant; regulates ilv and leu [[cgsc_site:967|CGSC]] | ||
| Line 128: | Line 150: | ||
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BF23 multiplication | BF23 multiplication | ||
| | |||
| | | | ||
Controls phage BF23 multiplication [[cgsc_site:966|CGSC]] | Controls phage BF23 multiplication [[cgsc_site:966|CGSC]] | ||
| Line 139: | Line 163: | ||
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-Glucoside | -Glucoside | ||
| | |||
| | | | ||
bglE; regulatory gene for BglA [[cgsc_site:961|CGSC]] | bglE; regulatory gene for BglA [[cgsc_site:961|CGSC]] | ||
| Line 150: | Line 176: | ||
| | | | ||
Biotin | Biotin | ||
| | |||
| | | | ||
bir, birB; biotin transport [[cgsc_site:953|CGSC]] | bir, birB; biotin transport [[cgsc_site:953|CGSC]] | ||
| Line 162: | Line 190: | ||
Branched chain | Branched chain | ||
| | | | ||
Mutants valine resistant, glycylvaline sensitive [[cgsc_site:949|CGSC]] | PMID:4590465 | ||
| | |||
Mutants valine resistant, glycylvaline sensitive [[cgsc_site:949|CGSC]] | |||
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| Line 172: | Line 202: | ||
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Branched chain | Branched chain | ||
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PMID:4590465 | |||
| | | | ||
Mutants valine resistant, glycylvaline sensitive [[cgsc_site:948|CGSC]] | Mutants valine resistant, glycylvaline sensitive [[cgsc_site:948|CGSC]] | ||
| Line 183: | Line 215: | ||
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Branched chain | Branched chain | ||
| | |||
| | | | ||
Low-affinity transport of Ile [[cgsc_site:947|CGSC]] | Low-affinity transport of Ile [[cgsc_site:947|CGSC]] | ||
| Line 194: | Line 228: | ||
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Bypass maltose | Bypass maltose | ||
| | |||
| | | | ||
Growth on maltose in MalT cells [[cgsc_site:944|CGSC]] | Growth on maltose in MalT cells [[cgsc_site:944|CGSC]] | ||
| Line 205: | Line 241: | ||
| | | | ||
Calcium | Calcium | ||
| | |||
| | | | ||
Calcium-proton antiport activity [[cgsc_site:941|CGSC]] | Calcium-proton antiport activity [[cgsc_site:941|CGSC]] | ||
| Line 216: | Line 254: | ||
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Calcium | Calcium | ||
| | |||
| | | | ||
Calcium transport; mutants defective in chemotaxis [[cgsc_site:940|CGSC]] | Calcium transport; mutants defective in chemotaxis [[cgsc_site:940|CGSC]] | ||
| Line 227: | Line 267: | ||
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Calcium | Calcium | ||
| | |||
| | | | ||
Calcium transport; mutants defective in chemotaxis [[cgsc_site:939|CGSC]] | Calcium transport; mutants defective in chemotaxis [[cgsc_site:939|CGSC]] | ||
| Line 238: | Line 280: | ||
| | | | ||
CDP diglyceride synthase | CDP diglyceride synthase | ||
| | |||
| | | | ||
Stability of CDP diglyceride synthase [[cgsc_site:18490|CGSC]] | Stability of CDP diglyceride synthase [[cgsc_site:18490|CGSC]] | ||
| Line 249: | Line 293: | ||
| | | | ||
Capsular polysaccharide synthesis | Capsular polysaccharide synthesis | ||
| | |||
| | | | ||
Colanic acid (CPS) biosynthesis [[cgsc_site:18463|CGSC]] | Colanic acid (CPS) biosynthesis [[cgsc_site:18463|CGSC]] | ||
| Line 260: | Line 306: | ||
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Capsular polysaccharide synthesis | Capsular polysaccharide synthesis | ||
| | |||
| | | | ||
Colanic acid (CPS) biosynthesis [[cgsc_site:18457|CGSC]] | Colanic acid (CPS) biosynthesis [[cgsc_site:18457|CGSC]] | ||
| Line 271: | Line 319: | ||
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Capsular polysaccharide synthesis | Capsular polysaccharide synthesis | ||
| | |||
| | | | ||
Colanic acid (CPS) biosynthesis [[cgsc_site:18454|CGSC]] | Colanic acid (CPS) biosynthesis [[cgsc_site:18454|CGSC]] | ||
| Line 282: | Line 332: | ||
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Capsular polysaccharide synthesis | Capsular polysaccharide synthesis | ||
| | |||
| | | | ||
Colanic acid (CPS) biosynthesis [[cgsc_site:51241|CGSC]] | Colanic acid (CPS) biosynthesis [[cgsc_site:51241|CGSC]] | ||
| Line 293: | Line 345: | ||
| | | | ||
Capsular polysaccharide synthesis | Capsular polysaccharide synthesis | ||
| | |||
| | | | ||
Colanic acid (CPS) biosynthesis [[cgsc_site:18448|CGSC]] | Colanic acid (CPS) biosynthesis [[cgsc_site:18448|CGSC]] | ||
| Line 304: | Line 358: | ||
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Conjugative plasmid expression | Conjugative plasmid expression | ||
| | |||
| | | | ||
Phage Q resistance, membrane protein [[cgsc_site:907|CGSC]] | Phage Q resistance, membrane protein [[cgsc_site:907|CGSC]] | ||
| Line 315: | Line 371: | ||
| | | | ||
Cold resistant growth | Cold resistant growth | ||
| | |||
| | | | ||
Allows cold-resistant growth [[cgsc_site:18445|CGSC]] | Allows cold-resistant growth [[cgsc_site:18445|CGSC]] | ||
| Line 326: | Line 384: | ||
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Carbon starvation induced | Carbon starvation induced | ||
| | |||
| | | | ||
Stationary phase inducible protein [[cgsc_site:36892|CGSC]] | Stationary phase inducible protein [[cgsc_site:36892|CGSC]] | ||
| Line 337: | Line 397: | ||
| | | | ||
Carbon starvation induced | Carbon starvation induced | ||
| | |||
| | | | ||
Stationary phase inducible protein [[cgsc_site:36895|CGSC]] | Stationary phase inducible protein [[cgsc_site:36895|CGSC]] | ||
| Line 348: | Line 410: | ||
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Carbon starvation induced | Carbon starvation induced | ||
| | |||
| | | | ||
Stationary phase inducible protein [[cgsc_site:36898|CGSC]] | Stationary phase inducible protein [[cgsc_site:36898|CGSC]] | ||
| Line 359: | Line 423: | ||
| | | | ||
Carbon starvation induced | Carbon starvation induced | ||
| | |||
| | | | ||
Stationary phase inducible protein [[cgsc_site:36998|CGSC]] | Stationary phase inducible protein [[cgsc_site:36998|CGSC]] | ||
| Line 370: | Line 436: | ||
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Carbohydrate uptake | Carbohydrate uptake | ||
| | |||
| | | | ||
Mutants have defective carbohydrate uptake [[cgsc_site:18442|CGSC]] | Mutants have defective carbohydrate uptake [[cgsc_site:18442|CGSC]] | ||
| Line 381: | Line 449: | ||
| | | | ||
Carbon-xylose metabolism | Carbon-xylose metabolism | ||
| | |||
| | | | ||
cxr; methyl glyoxal synthesis; D-xylose utilization [[cgsc_site:903|CGSC]] | cxr; methyl glyoxal synthesis; D-xylose utilization [[cgsc_site:903|CGSC]] | ||
| Line 392: | Line 462: | ||
| | | | ||
Cysteine | Cysteine | ||
| | |||
| | | | ||
Reading frame in opposite orientation within cysE gene; polypeptide synthesized in maxicells [[cgsc_site:55332|CGSC]] | Reading frame in opposite orientation within cysE gene; polypeptide synthesized in maxicells [[cgsc_site:55332|CGSC]] | ||
| Line 403: | Line 475: | ||
| | | | ||
D-Amino acid dehydrogenase | D-Amino acid dehydrogenase | ||
| | |||
| | | | ||
alnR; regulator of dad regulon [[cgsc_site:882|CGSC]] | alnR; regulator of dad regulon [[cgsc_site:882|CGSC]] | ||
| Line 414: | Line 488: | ||
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Dicarboxylic acid transport | Dicarboxylic acid transport | ||
| | |||
| | | | ||
Uptake of C-4 dicarboxylic acids; 3-fluoromalate resistance, D-tartrate resistant [[cgsc_site:871|CGSC]] | Uptake of C-4 dicarboxylic acids; 3-fluoromalate resistance, D-tartrate resistant [[cgsc_site:871|CGSC]] | ||
| Line 425: | Line 501: | ||
| | | | ||
Deletion | Deletion | ||
| | |||
| | | | ||
Affects frequency of IS1-mediated deletions; 1,000-fold reduction in deletion frequency [[cgsc_site:869|CGSC]] | Affects frequency of IS1-mediated deletions; 1,000-fold reduction in deletion frequency [[cgsc_site:869|CGSC]] | ||
| Line 436: | Line 514: | ||
| | | | ||
Diglyceride kinase | Diglyceride kinase | ||
| | |||
| | | | ||
Regulatory [[cgsc_site:861|CGSC]] | Regulatory [[cgsc_site:861|CGSC]] | ||
| Line 447: | Line 527: | ||
| | | | ||
Damage inducible | Damage inducible | ||
| | |||
| | | | ||
Repair gene [[cgsc_site:36880|CGSC]] | Repair gene [[cgsc_site:36880|CGSC]] | ||
| Line 458: | Line 540: | ||
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DNA | DNA | ||
| | |||
| | | | ||
DNA biosynthesis [[cgsc_site:846|CGSC]] | DNA biosynthesis [[cgsc_site:846|CGSC]] | ||
| Line 469: | Line 553: | ||
| | | | ||
Dipeptide permease | Dipeptide permease | ||
| | |||
| | | | ||
Uptake of dipeptides; dipeptide permease [[cgsc_site:835|CGSC]] | Uptake of dipeptides; dipeptide permease [[cgsc_site:835|CGSC]] | ||
| Line 480: | Line 566: | ||
| | | | ||
Dye-visible light? | Dye-visible light? | ||
| | |||
| | | | ||
Sensitivity to SDS and toluidine blue plus light [[cgsc_site:18418|CGSC]] | Sensitivity to SDS and toluidine blue plus light [[cgsc_site:18418|CGSC]] | ||
| Line 491: | Line 579: | ||
| | | | ||
Evolved -galactosidase | Evolved -galactosidase | ||
| | |||
| | | | ||
Cryptic -galactoside utilization, possible paralog of lacY [[cgsc_site:18415|CGSC]] | Cryptic -galactoside utilization, possible paralog of lacY [[cgsc_site:18415|CGSC]] | ||
| Line 502: | Line 592: | ||
| | | | ||
Envelope | Envelope | ||
| | |||
| | | | ||
Affects envelope; defects osmotically remedied [[cgsc_site:811|CGSC]] | Affects envelope; defects osmotically remedied [[cgsc_site:811|CGSC]] | ||
| Line 513: | Line 605: | ||
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Envelope | Envelope | ||
| | |||
| | | | ||
Affects envelope; defects osmotically remedied [[cgsc_site:810|CGSC]] | Affects envelope; defects osmotically remedied [[cgsc_site:810|CGSC]] | ||
| Line 524: | Line 618: | ||
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Envelope | Envelope | ||
| | |||
| | | | ||
Affects envelope; defects osmotically remedied [[cgsc_site:809|CGSC]] | Affects envelope; defects osmotically remedied [[cgsc_site:809|CGSC]] | ||
| Line 535: | Line 631: | ||
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Envelope | Envelope | ||
| | |||
| | | | ||
Affects envelope; defects osmotically remedied [[cgsc_site:808|CGSC]] | Affects envelope; defects osmotically remedied [[cgsc_site:808|CGSC]] | ||
| Line 546: | Line 644: | ||
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E-pentapeptide | E-pentapeptide | ||
| | |||
| | | | ||
Minigene within 23S rRNA encoding functional pentapeptide; erythromycin resistance [[cgsc_site:51135|CGSC]] | Minigene within 23S rRNA encoding functional pentapeptide; erythromycin resistance [[cgsc_site:51135|CGSC]] | ||
| Line 557: | Line 657: | ||
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Efficiency site for phage | Efficiency site for phage | ||
| | |||
| | | | ||
Site for efficient packaging of phage T1 [[cgsc_site:805|CGSC]] | Site for efficient packaging of phage T1 [[cgsc_site:805|CGSC]] | ||
| Line 568: | Line 670: | ||
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Export | Export | ||
| | |||
| | | | ||
Uptake of enterochelin; resistance or sensitivity to colicins [[cgsc_site:803|CGSC]] | Uptake of enterochelin; resistance or sensitivity to colicins [[cgsc_site:803|CGSC]] | ||
| Line 579: | Line 683: | ||
| | | | ||
Export | Export | ||
| | |||
| | | | ||
Expression of a group of export proteins [[cgsc_site:802|CGSC]] | Expression of a group of export proteins [[cgsc_site:802|CGSC]] | ||
| Line 590: | Line 696: | ||
| | | | ||
Fatty acid | Fatty acid | ||
| | |||
| | | | ||
Utilization of trans unsaturated fatty acids [[cgsc_site:18403|CGSC]] | Utilization of trans unsaturated fatty acids [[cgsc_site:18403|CGSC]] | ||
| Line 601: | Line 709: | ||
| | | | ||
Filamentous, cold sensitive | Filamentous, cold sensitive | ||
| | |||
| | | | ||
Cold-sensitive cell division mutant [[cgsc_site:787|CGSC]] | Cold-sensitive cell division mutant [[cgsc_site:787|CGSC]] | ||
| Line 612: | Line 722: | ||
| | | | ||
F exclusion | F exclusion | ||
| | |||
| | | | ||
Affects ArcA phenotype [[cgsc_site:778|CGSC]] | Affects ArcA phenotype [[cgsc_site:778|CGSC]] | ||
| Line 623: | Line 735: | ||
| | | | ||
Formate hydrogen-lyase | Formate hydrogen-lyase | ||
| | |||
| | | | ||
Formate hydrogen-lyase; activated by fhlA [[cgsc_site:36851|CGSC]] | Formate hydrogen-lyase; activated by fhlA [[cgsc_site:36851|CGSC]] | ||
| Line 634: | Line 748: | ||
| | | | ||
F1 phage | F1 phage | ||
| | |||
| | | | ||
Morphogenesis of phage F1 [[cgsc_site:18334|CGSC]] | Morphogenesis of phage F1 [[cgsc_site:18334|CGSC]] | ||
| Line 645: | Line 761: | ||
| | | | ||
F1 phage | F1 phage | ||
| | |||
| | | | ||
Morphogenesis of phage F1 [[cgsc_site:18331|CGSC]] | Morphogenesis of phage F1 [[cgsc_site:18331|CGSC]] | ||
| Line 656: | Line 774: | ||
| | | | ||
FKBP-like | FKBP-like | ||
| | |||
| | | | ||
Periplasmic PPIase, of FK506-binding protein type (EC 5.2.1.8); contains pipecolic acid residue [[cgsc_site:48137|CGSC]] | Periplasmic PPIase, of FK506-binding protein type (EC 5.2.1.8); contains pipecolic acid residue [[cgsc_site:48137|CGSC]] | ||
| Line 667: | Line 787: | ||
| | | | ||
Glutamate deCase | Glutamate deCase | ||
| | |||
| | | | ||
Regulatory gene for gat? [[cgsc_site:726|CGSC]] | Regulatory gene for gat? [[cgsc_site:726|CGSC]] | ||
| Line 678: | Line 800: | ||
| | | | ||
Glucarate | Glucarate | ||
| | |||
| | | | ||
D-Glucarate utilization [[cgsc_site:717|CGSC]] | D-Glucarate utilization [[cgsc_site:717|CGSC]] | ||
| Line 689: | Line 813: | ||
| | | | ||
Glucarate | Glucarate | ||
| | |||
| | | | ||
D-Glucarate utilization [[cgsc_site:716|CGSC]] | D-Glucarate utilization [[cgsc_site:716|CGSC]] | ||
| Line 700: | Line 826: | ||
| | | | ||
Glucosamine | Glucosamine | ||
| | |||
| | | | ||
Affects suppression of glmS mutations by nagB [[cgsc_site:36538|CGSC]] | Affects suppression of glmS mutations by nagB [[cgsc_site:36538|CGSC]] | ||
| Line 711: | Line 839: | ||
| | | | ||
Glutamate | Glutamate | ||
| | |||
| | | | ||
Glutamyl-tRNA synthetase; possible regulatory subunit [[cgsc_site:685|CGSC]] | Glutamyl-tRNA synthetase; possible regulatory subunit [[cgsc_site:685|CGSC]] | ||
| Line 722: | Line 852: | ||
| | | | ||
Glutamate | Glutamate | ||
| | |||
| | | | ||
Growth on glutamate [[cgsc_site:684|CGSC]] | Growth on glutamate [[cgsc_site:684|CGSC]] | ||
| Line 733: | Line 865: | ||
| | | | ||
Glutamate | Glutamate | ||
| | |||
| | | | ||
Growth on glutamate at 42C [[cgsc_site:682|CGSC]] | Growth on glutamate at 42C [[cgsc_site:682|CGSC]] | ||
| Line 744: | Line 878: | ||
| | | | ||
Growth of phage, replication | Growth of phage, replication | ||
| | |||
| | | | ||
Replication of certain lambdoid phage [[cgsc_site:15896|CGSC]] | Replication of certain lambdoid phage [[cgsc_site:15896|CGSC]] | ||
| Line 755: | Line 891: | ||
| | | | ||
Growth of phage, replication | Growth of phage, replication | ||
| | |||
| | | | ||
Replication of certain lambdoid phage [[cgsc_site:15890|CGSC]] | Replication of certain lambdoid phage [[cgsc_site:15890|CGSC]] | ||
| Line 766: | Line 904: | ||
| | | | ||
Glucuronide | Glucuronide | ||
| | |||
| | | | ||
Utilization of glucuronides [[cgsc_site:653|CGSC]] | Utilization of glucuronides [[cgsc_site:653|CGSC]] | ||
| Line 777: | Line 917: | ||
| | | | ||
Heterogeneous size | Heterogeneous size | ||
| | |||
| | | | ||
cop; possibly structural gene for DNA-binding protein; near ori [[cgsc_site:640|CGSC]] | cop; possibly structural gene for DNA-binding protein; near ori [[cgsc_site:640|CGSC]] | ||
| Line 788: | Line 930: | ||
| | | | ||
Heat shock locus | Heat shock locus | ||
| | |||
| | | | ||
Protein expressed as heat shock regulon member [[cgsc_site:36762|CGSC]] | Protein expressed as heat shock regulon member [[cgsc_site:36762|CGSC]] | ||
| Line 799: | Line 943: | ||
| | | | ||
Heat shock locus | Heat shock locus | ||
| | |||
| | | | ||
Protein expressed as heat shock regulon member [[cgsc_site:36765|CGSC]] | Protein expressed as heat shock regulon member [[cgsc_site:36765|CGSC]] | ||
| Line 810: | Line 956: | ||
| | | | ||
Heat shock locus | Heat shock locus | ||
| | |||
| | | | ||
Protein expressed as heat shock regulon member [[cgsc_site:36945|CGSC]] | Protein expressed as heat shock regulon member [[cgsc_site:36945|CGSC]] | ||
| Line 821: | Line 969: | ||
| | | | ||
Heat shock locus | Heat shock locus | ||
| | |||
| | | | ||
Heat-inducible; regulatory gene, near groE [[cgsc_site:41190|CGSC]] | Heat-inducible; regulatory gene, near groE [[cgsc_site:41190|CGSC]] | ||
| Line 832: | Line 982: | ||
| | | | ||
Isoleucine-valine (requirement) | Isoleucine-valine (requirement) | ||
| | |||
| | | | ||
Production of valine-resistant acetolactate synthase activity [[cgsc_site:604|CGSC]] | Production of valine-resistant acetolactate synthase activity [[cgsc_site:604|CGSC]] | ||
| Line 843: | Line 995: | ||
| | | | ||
Isoleucine-valine | Isoleucine-valine | ||
| | |||
| | | | ||
[[cgsc_site:15917|CGSC]] | [[cgsc_site:15917|CGSC]] | ||
| Line 854: | Line 1,008: | ||
| | | | ||
Isoleucine-valine (requirement) | Isoleucine-valine (requirement) | ||
| | |||
PMID:385587 | |||
| | | | ||
Regulation of ileS and modification of Ile tRNA2 and Val tRNA2 [[cgsc_site:599|CGSC]] | Regulation of ileS and modification of Ile tRNA2 and Val tRNA2 [[cgsc_site:599|CGSC]] | ||
| Line 865: | Line 1,021: | ||
| | | | ||
Insensitive NG mutagenesis | Insensitive NG mutagenesis | ||
| | |||
| | | | ||
Susceptibility to mutagenesis by nitrosoguanidine [[cgsc_site:595|CGSC]] | Susceptibility to mutagenesis by nitrosoguanidine [[cgsc_site:595|CGSC]] | ||
| Line 876: | Line 1,034: | ||
| | | | ||
Inhibits SOS function | Inhibits SOS function | ||
| | |||
| | | | ||
Regulatory gene; SOS-related [[cgsc_site:41044|CGSC]] | Regulatory gene; SOS-related [[cgsc_site:41044|CGSC]] | ||
| Line 887: | Line 1,047: | ||
| | | | ||
Kasugamycin | Kasugamycin | ||
| | |||
PMID:6257656 | |||
PMID:4570603 | |||
| | | | ||
High-level resistance to kasugamycin [[cgsc_site:582|CGSC]] | High-level resistance to kasugamycin [[cgsc_site:582|CGSC]] | ||
| Line 895: | Line 1,059: | ||
ksgC | ksgC | ||
| | | | ||
12. | 12.04-12.06 | ||
| | | | ||
Kasugamycin | Kasugamycin | ||
| | |||
PMID:1092672 | |||
| | | | ||
Resistance to kasugamycin; affects ribosomal protein S2 [[cgsc_site:581|CGSC]] | Resistance to kasugamycin; affects ribosomal protein S2 [[cgsc_site:581|CGSC]] | ||
| Line 909: | Line 1,075: | ||
| | | | ||
Kasugamycin | Kasugamycin | ||
| | |||
PMID:6257656 | |||
| | | | ||
Resistance to kasugamycin [[cgsc_site:580|CGSC]] | Resistance to kasugamycin [[cgsc_site:580|CGSC]] | ||
| Line 920: | Line 1,088: | ||
| | | | ||
Leucine (biosynthesis) | Leucine (biosynthesis) | ||
| | |||
| | | | ||
flr; regulation of leu and ilv operons [[cgsc_site:18196|CGSC]] | flr; regulation of leu and ilv operons [[cgsc_site:18196|CGSC]] | ||
| Line 931: | Line 1,101: | ||
| | | | ||
Leucine | Leucine | ||
| | |||
| | | | ||
Regulates level of leucyl-tRNA synthetase [[cgsc_site:567|CGSC]] | Regulates level of leucyl-tRNA synthetase [[cgsc_site:567|CGSC]] | ||
| Line 942: | Line 1,114: | ||
| | | | ||
Leucine | Leucine | ||
| | |||
| | | | ||
Regulates level of leucyl-tRNA synthetase [[cgsc_site:560|CGSC]] | Regulates level of leucyl-tRNA synthetase [[cgsc_site:560|CGSC]] | ||
| Line 953: | Line 1,127: | ||
| | | | ||
Levallorphan | Levallorphan | ||
| | |||
| | | | ||
Resistance to levallorphan [[cgsc_site:559|CGSC]] | Resistance to levallorphan [[cgsc_site:559|CGSC]] | ||
| Line 964: | Line 1,140: | ||
| | | | ||
Lincomycin | Lincomycin | ||
| | |||
| | | | ||
High-level lincomycin resistance [[cgsc_site:556|CGSC]] | High-level lincomycin resistance [[cgsc_site:556|CGSC]] | ||
| Line 975: | Line 1,153: | ||
| | | | ||
Lipopolysaccharide core | Lipopolysaccharide core | ||
| | |||
| | | | ||
mrc, pon; T-phage resistance, novobiocin sensitivity [[cgsc_site:545|CGSC]] | mrc, pon; T-phage resistance, novobiocin sensitivity [[cgsc_site:545|CGSC]] | ||
| Line 986: | Line 1,166: | ||
| | | | ||
L-Ribose (utilization) | L-Ribose (utilization) | ||
| | |||
| | | | ||
Affects NADPH-linked L-ribose reductase activity [[cgsc_site:36791|CGSC]] | Affects NADPH-linked L-ribose reductase activity [[cgsc_site:36791|CGSC]] | ||
| Line 997: | Line 1,179: | ||
| | | | ||
Lysine | Lysine | ||
| | |||
| | | | ||
Lysine excretion [[cgsc_site:536|CGSC]] | Lysine excretion [[cgsc_site:536|CGSC]] | ||
| Line 1,008: | Line 1,192: | ||
| | | | ||
Lytic | Lytic | ||
| | |||
| | | | ||
Tolerance to -lactams; autolysis [[cgsc_site:18184|CGSC]] | Tolerance to -lactams; autolysis [[cgsc_site:18184|CGSC]] | ||
| Line 1,019: | Line 1,205: | ||
| | | | ||
Maintenance of F | Maintenance of F | ||
| | |||
PMID:327277 | |||
PMID:391803 | |||
| | | | ||
Maintenance of F-like plasmids [[cgsc_site:534|CGSC]] | Maintenance of F-like plasmids [[cgsc_site:534|CGSC]] | ||
| Line 1,030: | Line 1,220: | ||
| | | | ||
Maintenance of F | Maintenance of F | ||
| | |||
PMID:391803 | |||
| | | | ||
Maintenance of F-like plasmids [[cgsc_site:533|CGSC]] | Maintenance of F-like plasmids [[cgsc_site:533|CGSC]] | ||
| Line 1,041: | Line 1,233: | ||
| | | | ||
Mothball resistant | Mothball resistant | ||
| | |||
PMID:2176633 | |||
| | | | ||
Resistance to camphor vapors; coupling of cell division and replication, growth rate and partitioning [[cgsc_site:36929|CGSC]] | Resistance to camphor vapors; coupling of cell division and replication, growth rate and partitioning [[cgsc_site:36929|CGSC]] | ||
| Line 1,052: | Line 1,246: | ||
| | | | ||
malE bypass | malE bypass | ||
| | |||
| | | | ||
Suppressor of malE secB-defective transport of mal-binding protein [[cgsc_site:28194|CGSC]] | Suppressor of malE secB-defective transport of mal-binding protein [[cgsc_site:28194|CGSC]] | ||
| Line 1,063: | Line 1,259: | ||
| | | | ||
Methyl-galactoside | Methyl-galactoside | ||
| | |||
| | | | ||
R-MG; regulatory gene [[cgsc_site:498|CGSC]] | R-MG; regulatory gene [[cgsc_site:498|CGSC]] | ||
| Line 1,074: | Line 1,272: | ||
| | | | ||
Manganese | Manganese | ||
| | |||
| | | | ||
Manganese resistance [[cgsc_site:494|CGSC]] | Manganese resistance [[cgsc_site:494|CGSC]] | ||
| Line 1,085: | Line 1,285: | ||
| | | | ||
Murein cluster a | Murein cluster a | ||
| | |||
| | | | ||
D-Alanine carboxypeptidase [[cgsc_site:489|CGSC]] | D-Alanine carboxypeptidase [[cgsc_site:489|CGSC]] | ||
| Line 1,096: | Line 1,298: | ||
| | | | ||
Mutability lambda | Mutability lambda | ||
| | |||
| | | | ||
Mutability in UV-radiated lambda phage [[cgsc_site:477|CGSC]] | Mutability in UV-radiated lambda phage [[cgsc_site:477|CGSC]] | ||
| Line 1,107: | Line 1,311: | ||
| | | | ||
Murein | Murein | ||
| | |||
| | | | ||
Terminal stage in peptidoglycan synthesis, incorporating disaccharide peptide units into wall [[cgsc_site:18136|CGSC]] | Terminal stage in peptidoglycan synthesis, incorporating disaccharide peptide units into wall [[cgsc_site:18136|CGSC]] | ||
| Line 1,118: | Line 1,324: | ||
| | | | ||
Mutator | Mutator | ||
| | |||
| | | | ||
Mutation causes high C-to-T mutation in second C of CCAGG; near but distinct from vsr; provisionally termed mutG [[cgsc_site:28933|CGSC]] | Mutation causes high C-to-T mutation in second C of CCAGG; near but distinct from vsr; provisionally termed mutG [[cgsc_site:28933|CGSC]] | ||
| Line 1,129: | Line 1,337: | ||
| | | | ||
Nalidixic acid | Nalidixic acid | ||
| | |||
PMID:4895844 | |||
PMID:8509326 | |||
| | | | ||
Sensitivity to nalidixic acid (NAL) [[cgsc_site:460|CGSC]] | Sensitivity to nalidixic acid (NAL) [[cgsc_site:460|CGSC]] | ||
| | | | ||
''emr'' locus according to [http://www.ncbi.nlm.nih.gov/pubmed/1409590 PMID:1409590] | |||
|- | |- | ||
| | | | ||
| Line 1,140: | Line 1,353: | ||
| | | | ||
Neamine | Neamine | ||
| | |||
PMID:4604727 | |||
PMID:358966 | |||
| | | | ||
Neamine sensitivity [[cgsc_site:456|CGSC]] | Neamine sensitivity [[cgsc_site:456|CGSC]] | ||
| Line 1,151: | Line 1,367: | ||
| | | | ||
Nitrofurantoin | Nitrofurantoin | ||
| | |||
PMID:6387400 | |||
| | | | ||
Nitrofurantoin sensitivity [[cgsc_site:18100|CGSC]] | Nitrofurantoin sensitivity [[cgsc_site:18100|CGSC]] | ||
| Line 1,162: | Line 1,380: | ||
| | | | ||
N4 (phage) resistant | N4 (phage) resistant | ||
| | |||
| | | | ||
Phage N4 susceptibility [[cgsc_site:36113|CGSC]] | Phage N4 susceptibility [[cgsc_site:36113|CGSC]] | ||
| Line 1,173: | Line 1,393: | ||
| | | | ||
Nonmucoid | Nonmucoid | ||
| | |||
| | | | ||
Affects capsule formation [[cgsc_site:446|CGSC]] | Affects capsule formation [[cgsc_site:446|CGSC]] | ||
| Line 1,184: | Line 1,406: | ||
| | | | ||
Oligopeptide permease | Oligopeptide permease | ||
| | |||
PMID:2981814 | |||
| | | | ||
Oligopeptide transport [[cgsc_site:18082|CGSC]] | Oligopeptide transport [[cgsc_site:18082|CGSC]] | ||
| Line 1,195: | Line 1,419: | ||
| | | | ||
rpo reversed | rpo reversed | ||
| | |||
| | | | ||
Rate of degradation of aberrant RNAP-subunit proteins [[cgsc_site:18079|CGSC]] | Rate of degradation of aberrant RNAP-subunit proteins [[cgsc_site:18079|CGSC]] | ||
| Line 1,206: | Line 1,432: | ||
| | | | ||
Overproduction of polysaccharide | Overproduction of polysaccharide | ||
| | |||
| | | | ||
Level of exopolysaccharide production [[cgsc_site:18076|CGSC]] | Level of exopolysaccharide production [[cgsc_site:18076|CGSC]] | ||
| Line 1,217: | Line 1,445: | ||
| | | | ||
Origin of replication | Origin of replication | ||
| | |||
| | | | ||
Locus in defective prophage rac [[cgsc_site:430|CGSC]] | Locus in defective prophage rac [[cgsc_site:430|CGSC]] | ||
| Line 1,228: | Line 1,458: | ||
| | | | ||
Phenylacetate | Phenylacetate | ||
| | |||
| | | | ||
Phenylacetate degradation [[cgsc_site:18067|CGSC]] | Phenylacetate degradation [[cgsc_site:18067|CGSC]] | ||
| Line 1,239: | Line 1,471: | ||
| | | | ||
Phage X | Phage X | ||
| | |||
| | | | ||
Adsorption of X154 [[cgsc_site:389|CGSC]] | Adsorption of X154 [[cgsc_site:389|CGSC]] | ||
| Line 1,250: | Line 1,484: | ||
| | | | ||
Proline oxidase | Proline oxidase | ||
| | |||
| | | | ||
Regulation of proline oxidase production [[cgsc_site:377|CGSC]] | Regulation of proline oxidase production [[cgsc_site:377|CGSC]] | ||
| Line 1,261: | Line 1,497: | ||
| | | | ||
Porphyrin | Porphyrin | ||
| | |||
| | | | ||
5-Aminolevulinate dehydratase (EC 4.2.1.24) [[cgsc_site:371|CGSC]] | 5-Aminolevulinate dehydratase (EC 4.2.1.24) [[cgsc_site:371|CGSC]] | ||
| Line 1,272: | Line 1,510: | ||
| | | | ||
Protein localization | Protein localization | ||
| | |||
| | | | ||
Suppresses export defects in signal sequence mutations [[cgsc_site:36421|CGSC]] | Suppresses export defects in signal sequence mutations [[cgsc_site:36421|CGSC]] | ||
| Line 1,283: | Line 1,523: | ||
| | | | ||
Proline | Proline | ||
| | |||
| | | | ||
Proline transport carrier protein, putative [[cgsc_site:359|CGSC]] | Proline transport carrier protein, putative [[cgsc_site:359|CGSC]] | ||
| Line 1,294: | Line 1,536: | ||
| | | | ||
Reverse of sup (amber) | Reverse of sup (amber) | ||
| | |||
| | | | ||
Reverses accentuation effects of amber suppressor on relB mutations [[cgsc_site:334|CGSC]] | Reverses accentuation effects of amber suppressor on relB mutations [[cgsc_site:334|CGSC]] | ||
| Line 1,305: | Line 1,549: | ||
| | | | ||
Q independent | Q independent | ||
| | |||
| | | | ||
kim; cryptic lambdoid phage [[cgsc_site:17529|CGSC]] | kim; cryptic lambdoid phage [[cgsc_site:17529|CGSC]] | ||
| Line 1,316: | Line 1,562: | ||
| | | | ||
Q membrane | Q membrane | ||
| | |||
PMID:4594014 | |||
| | | | ||
Glycine resistance; penicillin sensitivity; membrane defect [[cgsc_site:321|CGSC]] | Glycine resistance; penicillin sensitivity; membrane defect [[cgsc_site:321|CGSC]] | ||
| Line 1,327: | Line 1,575: | ||
| | | | ||
Q membrane | Q membrane | ||
| | |||
PMID:4594014 | |||
| | | | ||
Glycine resistance; penicillin sensitivity; membrane defect [[cgsc_site:320|CGSC]] | Glycine resistance; penicillin sensitivity; membrane defect [[cgsc_site:320|CGSC]] | ||
| Line 1,338: | Line 1,588: | ||
| | | | ||
Q membrane | Q membrane | ||
| | |||
PMID:4594014 | |||
| | | | ||
Glycine resistance; penicillin sensitivity; membrane defect [[cgsc_site:319|CGSC]] | Glycine resistance; penicillin sensitivity; membrane defect [[cgsc_site:319|CGSC]] | ||
| Line 1,349: | Line 1,601: | ||
| | | | ||
Radiation sensitive | Radiation sensitive | ||
| | |||
| | | | ||
Sensitive to X rays and UV [[cgsc_site:316|CGSC]] | Sensitive to X rays and UV [[cgsc_site:316|CGSC]] | ||
| Line 1,360: | Line 1,614: | ||
| | | | ||
RecA-dependent growth | RecA-dependent growth | ||
| | |||
| | | | ||
Dependence of growth upon recA gene product [[cgsc_site:17971|CGSC]] | Dependence of growth upon recA gene product [[cgsc_site:17971|CGSC]] | ||
| Line 1,371: | Line 1,627: | ||
| | | | ||
Relaxed | Relaxed | ||
| | |||
| | | | ||
Control of ppGpp synthesis [[cgsc_site:304|CGSC]] | Control of ppGpp synthesis [[cgsc_site:304|CGSC]] | ||
| Line 1,382: | Line 1,640: | ||
| | | | ||
Resistance to radiation | Resistance to radiation | ||
| | |||
| | | | ||
Resistance to UV and gamma radiation [[cgsc_site:302|CGSC]] | Resistance to UV and gamma radiation [[cgsc_site:302|CGSC]] | ||
| Line 1,393: | Line 1,653: | ||
| | | | ||
Rifampin dependence | Rifampin dependence | ||
| | |||
PMID:7035836 (rifampin and Kasugamycin dependence) | |||
PMID:6757665 | |||
| | | | ||
Rifampin resistance and dependence [[cgsc_site:285|CGSC]] | Rifampin resistance and dependence [[cgsc_site:285|CGSC]] | ||
| Line 1,404: | Line 1,668: | ||
| | | | ||
Rifampin dependence | Rifampin dependence | ||
| | |||
PMID:6757665 (Mutant is dependent on rifampin) | |||
| | | | ||
Transcription and translation; rifampin (rifamycin) sensitivity [[cgsc_site:17935|CGSC]] | Transcription and translation; rifampin (rifamycin) sensitivity [[cgsc_site:17935|CGSC]] | ||
| | | | ||
rho | |||
|- | |- | ||
| | | | ||
| Line 1,415: | Line 1,681: | ||
| | | | ||
Ribosomal modification | Ribosomal modification | ||
| | |||
| | | | ||
50S ribosomal subunit maturation [[cgsc_site:284|CGSC]] | 50S ribosomal subunit maturation [[cgsc_site:284|CGSC]] | ||
| Line 1,426: | Line 1,694: | ||
| | | | ||
Ribosomal modification | Ribosomal modification | ||
| | |||
| | | | ||
50S ribosomal subunit maturation [[cgsc_site:283|CGSC]] | 50S ribosomal subunit maturation [[cgsc_site:283|CGSC]] | ||
| Line 1,437: | Line 1,707: | ||
| | | | ||
Ribosomal modification | Ribosomal modification | ||
| | |||
| | | | ||
50S ribosomal subunit maturation [[cgsc_site:282|CGSC]] | 50S ribosomal subunit maturation [[cgsc_site:282|CGSC]] | ||
| Line 1,448: | Line 1,720: | ||
| | | | ||
Ribosomal modification | Ribosomal modification | ||
| | |||
| | | | ||
Ribosomal protein modification [[cgsc_site:281|CGSC]] | Ribosomal protein modification [[cgsc_site:281|CGSC]] | ||
| Line 1,459: | Line 1,733: | ||
| | | | ||
Ribosomal modification | Ribosomal modification | ||
| | |||
| | | | ||
stsB; ribosomal modification [[cgsc_site:278|CGSC]] | stsB; ribosomal modification [[cgsc_site:278|CGSC]] | ||
| Line 1,470: | Line 1,746: | ||
| | | | ||
Ribosomal thermolability | Ribosomal thermolability | ||
| | |||
| | | | ||
Affects thermolability of 50S ribosomal subunit [[cgsc_site:274|CGSC]] | Affects thermolability of 50S ribosomal subunit [[cgsc_site:274|CGSC]] | ||
| Line 1,481: | Line 1,759: | ||
| | | | ||
Roentgen resistance | Roentgen resistance | ||
| | |||
| | | | ||
Sensitivity to ionizing radiation, mitomycin C [[cgsc_site:36611|CGSC]] | Sensitivity to ionizing radiation, mitomycin C [[cgsc_site:36611|CGSC]] | ||
| Line 1,492: | Line 1,772: | ||
| | | | ||
Suppresses disulfide bond | Suppresses disulfide bond | ||
| | |||
| | | | ||
Motility defects [[cgsc_site:|CGSC]] | Motility defects [[cgsc_site:|CGSC]] | ||
| Line 1,502: | Line 1,784: | ||
40.5 | 40.5 | ||
| | | | ||
Reduced sensitivity to microcin | |||
| | |||
PMID:3309133 | |||
| | | | ||
Sensitivity to microcin E492 [[cgsc_site:17884|CGSC]] | Sensitivity to microcin E492 [[cgsc_site:17884|CGSC]] | ||
| | | | ||
Has been mapped near pabB gene | |||
|- | |- | ||
| | | | ||
| Line 1,514: | Line 1,798: | ||
| | | | ||
Serine | Serine | ||
| | |||
| | | | ||
Regulates level of seryl-tRNA synthetase [[cgsc_site:|CGSC]] | Regulates level of seryl-tRNA synthetase [[cgsc_site:|CGSC]] | ||
| Line 1,525: | Line 1,811: | ||
| | | | ||
Septum formation inhibition | Septum formation inhibition | ||
| | |||
PMID:3011740 | |||
| | | | ||
Element of e14, inhibitor of cell division [[cgsc_site:17875|CGSC]] | Element of e14, inhibitor of cell division [[cgsc_site:17875|CGSC]] | ||
| Line 1,536: | Line 1,824: | ||
| | | | ||
Suppressor of increased permeability | Suppressor of increased permeability | ||
| | |||
| | | | ||
Mutations reverse the susceptibility to vancomycin and other hydrophobic antibiotics caused by TraT plasmid gene [[cgsc_site:51306|CGSC]] | Mutations reverse the susceptibility to vancomycin and other hydrophobic antibiotics caused by TraT plasmid gene [[cgsc_site:51306|CGSC]] | ||
| Line 1,547: | Line 1,837: | ||
| | | | ||
Suppressor of increased permeability | Suppressor of increased permeability | ||
| | |||
| | | | ||
Same phenotype as that produced by sipC [[cgsc_site:36869|CGSC]] | Same phenotype as that produced by sipC [[cgsc_site:36869|CGSC]] | ||
| Line 1,558: | Line 1,850: | ||
| | | | ||
SOS-independent repair | SOS-independent repair | ||
| | |||
| | | | ||
SOS-independent repair of mitomycin C-induced DNA damage [[cgsc_site:36505|CGSC]] | SOS-independent repair of mitomycin C-induced DNA damage [[cgsc_site:36505|CGSC]] | ||
| Line 1,569: | Line 1,863: | ||
| | | | ||
Slow growth | Slow growth | ||
| | |||
| | | | ||
Tolerance for amidinopenicillin and nalidixic acid; slow growth rate [[cgsc_site:162|CGSC]] | Tolerance for amidinopenicillin and nalidixic acid; slow growth rate [[cgsc_site:162|CGSC]] | ||
| Line 1,580: | Line 1,876: | ||
| | | | ||
Sorbitol | Sorbitol | ||
| | |||
| | | | ||
gutR; regulatory gene for srl [[cgsc_site:152|CGSC]] | gutR; regulatory gene for srl [[cgsc_site:152|CGSC]] | ||
| Line 1,591: | Line 1,889: | ||
| | | | ||
Stable RNA | Stable RNA | ||
| | |||
| | | | ||
Degradation of stable RNA [[cgsc_site:151|CGSC]] | Degradation of stable RNA [[cgsc_site:151|CGSC]] | ||
| Line 1,602: | Line 1,902: | ||
| | | | ||
Suppression secA | Suppression secA | ||
| | |||
| | | | ||
Suppresses secA mutations [[cgsc_site:17869|CGSC]] | Suppresses secA mutations [[cgsc_site:17869|CGSC]] | ||
| Line 1,613: | Line 1,915: | ||
| | | | ||
Suppression secA | Suppression secA | ||
| | |||
| | | | ||
Suppresses secA mutations [[cgsc_site:17866|CGSC]] | Suppresses secA mutations [[cgsc_site:17866|CGSC]] | ||
| Line 1,624: | Line 1,928: | ||
| | | | ||
Suppression secA | Suppression secA | ||
| | |||
| | | | ||
Suppresses secA mutations [[cgsc_site:17863|CGSC]] | Suppresses secA mutations [[cgsc_site:17863|CGSC]] | ||
| Line 1,635: | Line 1,941: | ||
| | | | ||
Suppression of secY | Suppression of secY | ||
| | |||
| | | | ||
Suppressor of secY mutation [[cgsc_site:17848|CGSC]] | Suppressor of secY mutation [[cgsc_site:17848|CGSC]] | ||
| Line 1,647: | Line 1,955: | ||
fts in reverse | fts in reverse | ||
| | | | ||
Antisense RNA blocks ftsZ mRNA translation, inhibits cell division [[cgsc_site:36124|CGSC]] | PMID:8226652 | ||
| | |||
Antisense RNA blocks ftsZ mRNA translation, only inhibits cell division when overexpressed at high temperatures [[cgsc_site:36124|CGSC]] | |||
| | | | ||
| Line 1,657: | Line 1,967: | ||
| | | | ||
Suppressor of transposase killing | Suppressor of transposase killing | ||
| | |||
| | | | ||
Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36083|CGSC]] | Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36083|CGSC]] | ||
| Line 1,668: | Line 1,980: | ||
| | | | ||
Suppressor of transposase killing | Suppressor of transposase killing | ||
| | |||
| | | | ||
Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36093|CGSC]] | Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36093|CGSC]] | ||
| Line 1,679: | Line 1,993: | ||
| | | | ||
Suppressor of transposase killing | Suppressor of transposase killing | ||
| | |||
| | | | ||
Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36087|CGSC]] | Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36087|CGSC]] | ||
| Line 1,690: | Line 2,006: | ||
| | | | ||
Suppressor of transposase killing | Suppressor of transposase killing | ||
| | |||
| | | | ||
Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36090|CGSC]] | Suppresses cell aberrations and death caused by Tn5 transposase overexpression [[cgsc_site:36090|CGSC]] | ||
| Line 1,701: | Line 2,019: | ||
| | | | ||
Streptomycin | Streptomycin | ||
| | |||
| | | | ||
strB; low-level streptomycin resistance; modifies ribosome structure [[cgsc_site:149|CGSC]] | strB; low-level streptomycin resistance; modifies ribosome structure [[cgsc_site:149|CGSC]] | ||
| Line 1,712: | Line 2,032: | ||
| | | | ||
Streptomycin | Streptomycin | ||
| | |||
| | | | ||
asuF?; control of ribosomal ambiguity [[cgsc_site:148|CGSC]] | asuF?; control of ribosomal ambiguity [[cgsc_site:148|CGSC]] | ||
| Line 1,721: | Line 2,043: | ||
| | | | ||
84.7 | 84.7 | ||
| | |||
| | | | ||
| Line 1,734: | Line 2,058: | ||
| | | | ||
Suppressor heat-shock proteins | Suppressor heat-shock proteins | ||
| | |||
| | | | ||
Induction of heat shock genes [[cgsc_site:17839|CGSC]] | Induction of heat shock genes [[cgsc_site:17839|CGSC]] | ||
| Line 1,745: | Line 2,071: | ||
| | | | ||
T4 abortion | T4 abortion | ||
| | |||
| | | | ||
Mutants fail to support growth of T4 [[cgsc_site:125|CGSC]] | Mutants fail to support growth of T4 [[cgsc_site:125|CGSC]] | ||
| Line 1,756: | Line 2,084: | ||
| | | | ||
Trehalose, anaerobic | Trehalose, anaerobic | ||
| | |||
| | | | ||
Anaerobic growth on trehalose [[cgsc_site:37222|CGSC]] | Anaerobic growth on trehalose [[cgsc_site:37222|CGSC]] | ||
| Line 1,767: | Line 2,097: | ||
| | | | ||
Trehalose, anaerobic | Trehalose, anaerobic | ||
| | |||
| | | | ||
Anaerobic growth on trehalose [[cgsc_site:37910|CGSC]] | Anaerobic growth on trehalose [[cgsc_site:37910|CGSC]] | ||
| Line 1,778: | Line 2,110: | ||
| | | | ||
Transduction inhibition | Transduction inhibition | ||
| | |||
| | | | ||
Affects transduction, transformation, and rates of mutation [[cgsc_site:121|CGSC]] | Affects transduction, transformation, and rates of mutation [[cgsc_site:121|CGSC]] | ||
| Line 1,789: | Line 2,123: | ||
| | | | ||
Thiophene degradation | Thiophene degradation | ||
| | |||
| | | | ||
Degradation of furans and thiophenes; may be tlnA? [[cgsc_site:17824|CGSC]] | Degradation of furans and thiophenes; may be tlnA? [[cgsc_site:17824|CGSC]] | ||
| | | | ||
|- | |||
| | |||
psu | |||
| | |||
1.3 min | |||
| | |||
polarity suppressor | |||
| | |||
| | |||
PMID:8380152 | |||
| | |||
[[hepA]] | |||
|- | |- | ||
| | | | ||
| Line 1,800: | Line 2,149: | ||
| | | | ||
Thiophene degradation | Thiophene degradation | ||
| | |||
| | | | ||
Degradation of furans and thiophenes [[cgsc_site:17821|CGSC]] | Degradation of furans and thiophenes [[cgsc_site:17821|CGSC]] | ||
| Line 1,811: | Line 2,162: | ||
| | | | ||
Thiophene degradation | Thiophene degradation | ||
| | |||
| | | | ||
Degradation of furans and thiophenes [[cgsc_site:15908|CGSC]] | Degradation of furans and thiophenes [[cgsc_site:15908|CGSC]] | ||
| | |||
|- | |||
| | |||
ackB | |||
| | |||
39 min | |||
| | |||
acetate kinase | |||
| | |||
PMID:7033467 | |||
| | |||
Ack- mutants were defective in aerobic growth on acetate or glucose as well as acetate accumulation from glucose & mapped near 39' (ackA mapped to ~50'). [[cgsc_site:19551|CGSC]] | |||
| | | | ||
| Line 1,822: | Line 2,188: | ||
| | | | ||
Thiolutin | Thiolutin | ||
| | |||
| | | | ||
tlnI; resistance or sensitivity to thiolutin; may be thdA? [[cgsc_site:102|CGSC]] | tlnI; resistance or sensitivity to thiolutin; may be thdA? [[cgsc_site:102|CGSC]] | ||
| Line 1,828: | Line 2,196: | ||
|- | |- | ||
| | | | ||
alaB | |||
| | |||
| | | | ||
alanine-glutamate transaminase | |||
| | | | ||
PMID:2890623 | |||
| | | | ||
alaB was found to be capable of multi-copy suppression of an alanine auxotrophy. | |||
| | | | ||
|- | |- | ||
| | | | ||
tnm | |||
| | |||
92.0 | |||
| | | | ||
Tn migration | |||
| | | | ||
| | | | ||
Transposition of Tn9 and other transposons, development of phage Mu [[cgsc_site:100|CGSC]] | |||
| | | | ||
|- | |- | ||
| | | | ||
dgd | |||
| | |||
| | | | ||
D-galactose dehydrogenase | |||
| | | | ||
| | | | ||
| | | | ||
|- | |- | ||
| | | | ||
tolD | |||
| | | | ||
22.9 | |||
| | | | ||
Tolerance | Tolerance | ||
| | | | ||
Bacteriocin tolerant; | |||
| | |||
Bacteriocin tolerant; tolerance to colicins E2, E3, and ampicillin [[cgsc_site:96|CGSC]] | |||
| | | | ||
|- | |- | ||
| | | | ||
treE | |||
| | |||
| | | | ||
catabolic trehalose-6-phosphate phosphatase | |||
| | | | ||
PMID:8391102 | |||
| | | | ||
In the absence of osmotic stress, trehalose induces converstion to free glucose and a glucose polymer, in a pathway involving TreE. | |||
| | | | ||
|- | |- | ||
| | | | ||
tolE | |||
| | |||
22.9 | |||
| | | | ||
Tolerance | |||
| | | | ||
| | | | ||
Bacteriocin tolerant; tolerance to colicins E2, E3, and ampicillin [[cgsc_site:95|CGSC]] | |||
| | | | ||
|- | |- | ||
| | | | ||
tolI | |||
| | | | ||
0.1 | |||
| | | | ||
Tolerance | |||
| | | | ||
| | |||
[[cgsc_site: | Bacteriocin tolerant; sensitivity to colicins Ia and Ib [[cgsc_site:94|CGSC]] | ||
| | | | ||
|- | |- | ||
| | | | ||
tolJ | |||
| | |||
0.1 | |||
| | | | ||
Tolerance | |||
| | | | ||
| | | | ||
Bacteriocin tolerant; sensitivity to L, A, S4, E, and K [[cgsc_site:93|CGSC]] | |||
| | | | ||
|- | |- | ||
| | | | ||
tsmA | |||
| | | | ||
91.1 | 40.1 | ||
| | |||
Thymine suppression modifier | |||
| | |||
| | |||
Affects suppression efficiency for nonsense and frameshift mutations of Thy strains [[cgsc_site:36603|CGSC]] | |||
| | |||
|- | |||
| | |||
ups | |||
| | |||
27.1 | |||
| | |||
Up-suppression | |||
| | |||
PMID:345090 | |||
| | |||
Increases efficiency of nonsense suppressors | |||
[[cgsc_site:23|CGSC]] | |||
| | |||
Proposed to be an allele of prfA<ref name='PMID:7508076'/> | |||
|- | |||
| | |||
uvh | |||
| | |||
90.2 | |||
| | |||
UV hyperresistant to UVC | |||
| | |||
PMID:8988611 | |||
| | |||
Resistance to UVC, peroxide and antibiotics; may affect SOS repair [[cgsc_site:51073|CGSC]] | |||
| | |||
|- | |||
| | |||
uvs | |||
| | |||
91.1 | |||
| | | | ||
UV sensitivity | UV sensitivity | ||
| | | | ||
UV-sensitive mutants, locus linked to uvr | PMID:8988611 | ||
| | |||
UV-sensitive mutants, locus linked to uvr [[cgsc_site:51076|CGSC]] | |||
| | |||
|- | |||
| | |||
adhB | |||
| | |||
19.1 | |||
| | |||
Alcohol dehydrogenase | |||
| | |||
| | |||
Alcohol dehydrogenase [[cgsc_site:36932|CGSC]] | |||
| | |||
|- | |||
| | |||
''tlmR'' | |||
| | |||
57.5 min | |||
| | |||
Thiolactomycin resistance. | |||
| | |||
PMID:8509326 | |||
| | |||
| | |||
[http://ecoliwiki.net/colipedia/index.php/emrB ''emrB''] | |||
|- | |||
| | |||
''hipQ'' | |||
| | |||
.7 minfrom the leu locus (2 min) | |||
| | |||
Persistence | |||
| | |||
PMID:1963289 | |||
| | |||
High persistence mutation. | |||
| | | | ||
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Latest revision as of 20:48, 27 November 2012
This page has a list of genes that are described in the 1998 linkage map for E. coli K-12 (Edition 10)[1] but have not been correlated with a gene in EcoliWiki. In most cases, the alleles that led to assignment of these gene names are likely to affect known genes, but which gene has not been determined.
Further information about a particular gene may be found on the EcoliWiki page for the publication(s) describing the mutants. Click on the PMID: link to access that page.
| Gene | Approx. Map Location | Mnemonic | Paper(s) describing gene | Notes | Candidate gene(s) |
|---|---|---|---|---|---|
|
abpS |
63.5 |
Arg binding protein |
Low-affinity transport system for arginine and ornithine; periplasmic binding protein CGSC |
||
|
abs |
94.1 |
Antibiotic sensitivity |
Sensitivity and permeability to antibiotics and dyes CGSC |
||
|
acpX |
43.9 |
Acyl carrier protein |
acpS; originally thought to be holo-ACP synthase; perhaps cryptic second gene or regulator CGSC |
||
|
acrC |
4.5 |
Acridine |
Sensitivity to acriflavine; transmembrane protein CGSC |
||
|
adhB |
19.1 |
Alcohol dehydrogenase |
Alcohol dehydrogenase CGSC |
||
|
aga |
70.7 |
Acetylgalactosamine |
Cluster of putative N-acetylgalactosamine pathway genes, including the kba gene, and mannose permease homologs CGSC |
||
|
aroI |
84.2 |
Aromatic |
Function unknown CGSC |
||
|
azaA |
44.6 |
Azaserine |
Mutants azaserine resistant CGSC |
||
|
azaB |
71.9 |
Azaserine |
Mutants azaserine resistant CGSC |
||
|
azl |
58.1 |
Azaleucine |
Mutants azaleucine resistant; regulates ilv and leu CGSC |
||
|
bfm |
85.9 |
BF23 multiplication |
Controls phage BF23 multiplication CGSC |
||
|
bglT |
84.9 |
-Glucoside |
bglE; regulatory gene for BglA CGSC |
||
|
bioP |
86.6 |
Biotin |
bir, birB; biotin transport CGSC |
||
|
brnR |
8.5 |
Branched chain |
Mutants valine resistant, glycylvaline sensitive CGSC |
||
|
brnS |
1.2 |
Branched chain |
Mutants valine resistant, glycylvaline sensitive CGSC |
||
|
brnT |
65.2 |
Branched chain |
Low-affinity transport of Ile CGSC |
||
|
bymA |
93.2 |
Bypass maltose |
Growth on maltose in MalT cells CGSC |
||
|
calA |
95.0 |
Calcium |
Calcium-proton antiport activity CGSC |
||
|
calC |
15.2 |
Calcium |
Calcium transport; mutants defective in chemotaxis CGSC |
||
|
calD |
9.4 |
Calcium |
Calcium transport; mutants defective in chemotaxis CGSC |
||
|
cdsS |
71.7 |
CDP diglyceride synthase |
Stability of CDP diglyceride synthase CGSC |
||
|
cpsA |
45.4 |
Capsular polysaccharide synthesis |
Colanic acid (CPS) biosynthesis CGSC |
||
|
cpsC |
45.8 |
Capsular polysaccharide synthesis |
Colanic acid (CPS) biosynthesis CGSC |
||
|
cpsD |
45.8 |
Capsular polysaccharide synthesis |
Colanic acid (CPS) biosynthesis CGSC |
||
|
cpsE |
45.8 |
Capsular polysaccharide synthesis |
Colanic acid (CPS) biosynthesis CGSC |
||
|
cpsF |
90.2 |
Capsular polysaccharide synthesis |
Colanic acid (CPS) biosynthesis CGSC |
||
|
cpxB |
41.3 |
Conjugative plasmid expression |
Phage Q resistance, membrane protein CGSC |
||
|
crg |
28.8 |
Cold resistant growth |
Allows cold-resistant growth CGSC |
||
|
csiA |
85.3 |
Carbon starvation induced |
Stationary phase inducible protein CGSC |
||
|
csiB |
17.4 |
Carbon starvation induced |
Stationary phase inducible protein CGSC |
||
|
csiC |
66.0 |
Carbon starvation induced |
Stationary phase inducible protein CGSC |
||
|
csiF |
8.6 |
Carbon starvation induced |
Stationary phase inducible protein CGSC |
||
|
cup |
97.0 |
Carbohydrate uptake |
Mutants have defective carbohydrate uptake CGSC |
||
|
cxm |
6.3 |
Carbon-xylose metabolism |
cxr; methyl glyoxal synthesis; D-xylose utilization CGSC |
||
|
cysX |
81.5 |
Cysteine |
Reading frame in opposite orientation within cysE gene; polypeptide synthesized in maxicells CGSC |
||
|
dadQ |
98.9 |
D-Amino acid dehydrogenase |
alnR; regulator of dad regulon CGSC |
||
|
dctB |
16.4 |
Dicarboxylic acid transport |
Uptake of C-4 dicarboxylic acids; 3-fluoromalate resistance, D-tartrate resistant CGSC |
||
|
del |
64.3 |
Deletion |
Affects frequency of IS1-mediated deletions; 1,000-fold reduction in deletion frequency CGSC |
||
|
dgkR |
93.7 |
Diglyceride kinase |
Regulatory CGSC |
||
|
dinY |
41.9 |
Damage inducible |
Repair gene CGSC |
||
|
dnaI |
40.3 |
DNA |
DNA biosynthesis CGSC |
||
|
dppG |
14.0 |
Dipeptide permease |
Uptake of dipeptides; dipeptide permease CGSC |
||
|
dvl |
7.4 |
Dye-visible light? |
Sensitivity to SDS and toluidine blue plus light CGSC |
||
|
ebgB |
69.5 |
Evolved -galactosidase |
Cryptic -galactoside utilization, possible paralog of lacY CGSC |
||
|
envN |
4.2 |
Envelope |
Affects envelope; defects osmotically remedied CGSC |
||
|
envP |
90.4 |
Envelope |
Affects envelope; defects osmotically remedied CGSC |
||
|
envQ |
60.7 |
Envelope |
Affects envelope; defects osmotically remedied CGSC |
||
|
envT |
14.2 |
Envelope |
Affects envelope; defects osmotically remedied CGSC |
||
|
epp |
E-pentapeptide |
Minigene within 23S rRNA encoding functional pentapeptide; erythromycin resistance CGSC |
|||
|
esp |
17.3 |
Efficiency site for phage |
Site for efficient packaging of phage T1 CGSC |
||
|
exbC |
61.5 |
Export |
Uptake of enterochelin; resistance or sensitivity to colicins CGSC |
||
|
expA |
22.2 |
Export |
Expression of a group of export proteins CGSC |
||
|
fatA |
71.7 |
Fatty acid |
Utilization of trans unsaturated fatty acids CGSC |
||
|
fcsA |
86.9 |
Filamentous, cold sensitive |
Cold-sensitive cell division mutant CGSC |
||
|
fexB |
86.7 |
F exclusion |
Affects ArcA phenotype CGSC |
||
|
fhlB |
95.1 |
Formate hydrogen-lyase |
Formate hydrogen-lyase; activated by fhlA CGSC |
||
|
fipB |
86.0 |
F1 phage |
Morphogenesis of phage F1 CGSC |
||
|
fipC |
75.0 |
F1 phage |
Morphogenesis of phage F1 CGSC |
||
|
flkB |
95.4 |
FKBP-like |
Periplasmic PPIase, of FK506-binding protein type (EC 5.2.1.8); contains pipecolic acid residue CGSC |
||
|
gadR |
79.6 |
Glutamate deCase |
Regulatory gene for gat? CGSC |
||
|
garA |
15.8 |
Glucarate |
D-Glucarate utilization CGSC |
||
|
garB |
3.6 |
Glucarate |
D-Glucarate utilization CGSC |
||
|
glmX |
26.2 |
Glucosamine |
Affects suppression of glmS mutations by nagB CGSC |
||
|
gltE |
81.4 |
Glutamate |
Glutamyl-tRNA synthetase; possible regulatory subunit CGSC |
||
|
gltH |
21.8 |
Glutamate |
Growth on glutamate CGSC |
||
|
gltR |
92.3 |
Glutamate |
Growth on glutamate at 42C CGSC |
||
|
gprA |
0.3 |
Growth of phage, replication |
Replication of certain lambdoid phage CGSC |
||
|
gprB |
0.2 |
Growth of phage, replication |
Replication of certain lambdoid phage CGSC |
||
|
gurC |
18.0 |
Glucuronide |
Utilization of glucuronides CGSC |
||
|
het |
84.6 |
Heterogeneous size |
cop; possibly structural gene for DNA-binding protein; near ori CGSC |
||
|
hslC |
19.9 |
Heat shock locus |
Protein expressed as heat shock regulon member CGSC |
||
|
hslD |
24.1 |
Heat shock locus |
Protein expressed as heat shock regulon member CGSC |
||
|
hslK |
40.7 |
Heat shock locus |
Protein expressed as heat shock regulon member CGSC |
||
|
hslW |
94.2 |
Heat shock locus |
Heat-inducible; regulatory gene, near groE CGSC |
||
|
ilvF |
57.0 |
Isoleucine-valine (requirement) |
Production of valine-resistant acetolactate synthase activity CGSC |
||
|
ilvR |
99.9 |
Isoleucine-valine |
|||
|
ilvU |
6.4 |
Isoleucine-valine (requirement) |
Regulation of ileS and modification of Ile tRNA2 and Val tRNA2 CGSC |
||
|
inm |
79.0 |
Insensitive NG mutagenesis |
Susceptibility to mutagenesis by nitrosoguanidine CGSC |
||
|
isfA |
86.0 |
Inhibits SOS function |
Regulatory gene; SOS-related CGSC |
||
|
ksgB |
37.7 |
Kasugamycin |
High-level resistance to kasugamycin CGSC |
||
|
ksgC |
12.04-12.06 |
Kasugamycin |
Resistance to kasugamycin; affects ribosomal protein S2 CGSC |
||
|
ksgD |
30.9 |
Kasugamycin |
Resistance to kasugamycin CGSC |
||
|
leuJ |
13.7 |
Leucine (biosynthesis) |
flr; regulation of leu and ilv operons CGSC |
||
|
leuR |
79.3 |
Leucine |
Regulates level of leucyl-tRNA synthetase CGSC |
||
|
leuY |
9.5 |
Leucine |
Regulates level of leucyl-tRNA synthetase CGSC |
||
|
lev |
9.0 |
Levallorphan |
Resistance to levallorphan CGSC |
||
|
linB |
29.3 |
Lincomycin |
High-level lincomycin resistance CGSC |
||
|
lpcB |
68.0 |
Lipopolysaccharide core |
mrc, pon; T-phage resistance, novobiocin sensitivity CGSC |
||
|
lrb |
7.3 |
L-Ribose (utilization) |
Affects NADPH-linked L-ribose reductase activity CGSC |
||
|
lysX |
63.3 |
Lysine |
Lysine excretion CGSC |
||
|
lytA |
60.6 |
Lytic |
Tolerance to -lactams; autolysis CGSC |
||
|
mafA |
0.9 |
Maintenance of F |
Maintenance of F-like plasmids CGSC |
||
|
mafB |
1.9 |
Maintenance of F |
Maintenance of F-like plasmids CGSC |
||
|
mbrB |
88.6 |
Mothball resistant |
Resistance to camphor vapors; coupling of cell division and replication, growth rate and partitioning CGSC |
||
|
meb |
78.7 |
malE bypass |
Suppressor of malE secB-defective transport of mal-binding protein CGSC |
||
|
mglR |
16.9 |
Methyl-galactoside |
R-MG; regulatory gene CGSC |
||
|
mng |
40.0 |
Manganese |
Manganese resistance CGSC |
||
|
mraA |
2.0 |
Murein cluster a |
D-Alanine carboxypeptidase CGSC |
||
|
mul |
83.1 |
Mutability lambda |
Mutability in UV-radiated lambda phage CGSC |
||
|
murH |
99.3 |
Murein |
Terminal stage in peptidoglycan synthesis, incorporating disaccharide peptide units into wall CGSC |
||
|
mutG |
43.7 |
Mutator |
Mutation causes high C-to-T mutation in second C of CCAGG; near but distinct from vsr; provisionally termed mutG CGSC |
||
|
nalB |
60.2 |
Nalidixic acid |
Sensitivity to nalidixic acid (NAL) CGSC |
emr locus according to PMID:1409590 | |
|
neaB |
75.0 |
Neamine |
Neamine sensitivity CGSC |
||
|
nfnA |
80.8 |
Nitrofurantoin |
Nitrofurantoin sensitivity CGSC |
||
|
nfrD |
54.2 |
N4 (phage) resistant |
Phage N4 susceptibility CGSC |
||
|
non |
45.7 |
Nonmucoid |
Affects capsule formation CGSC |
||
|
oppE |
98.9 |
Oligopeptide permease |
Oligopeptide transport CGSC |
||
|
opr |
19.0 |
rpo reversed |
Rate of degradation of aberrant RNAP-subunit proteins CGSC |
||
|
ops |
66.1 |
Overproduction of polysaccharide |
Level of exopolysaccharide production CGSC |
||
|
oriJ |
30.5 |
Origin of replication |
Locus in defective prophage rac CGSC |
||
|
pac |
31.0 |
Phenylacetate |
Phenylacetate degradation CGSC |
||
|
phxB |
17.0 |
Phage X |
Adsorption of X154 CGSC |
||
|
poaR |
65.9 |
Proline oxidase |
Regulation of proline oxidase production CGSC |
||
|
popD |
0.2 |
Porphyrin |
5-Aminolevulinate dehydratase (EC 4.2.1.24) CGSC |
||
|
prlZ |
71.4 |
Protein localization |
Suppresses export defects in signal sequence mutations CGSC |
||
|
proT |
83.8 |
Proline |
Proline transport carrier protein, putative CGSC |
||
|
pus |
20.6 |
Reverse of sup (amber) |
Reverses accentuation effects of amber suppressor on relB mutations CGSC |
||
|
qin |
35.1 |
Q independent |
kim; cryptic lambdoid phage CGSC |
||
|
qmeC |
75.3 |
Q membrane |
Glycine resistance; penicillin sensitivity; membrane defect CGSC |
||
|
qmeD |
64.4 |
Q membrane |
Glycine resistance; penicillin sensitivity; membrane defect CGSC |
||
|
qmeE |
37.9 |
Q membrane |
Glycine resistance; penicillin sensitivity; membrane defect CGSC |
||
|
ras |
9.9 |
Radiation sensitive |
Sensitive to X rays and UV CGSC |
||
|
rdgA |
16.1 |
RecA-dependent growth |
Dependence of growth upon recA gene product CGSC |
||
|
relX |
62.8 |
Relaxed |
Control of ppGpp synthesis CGSC |
||
|
rer |
89.9 |
Resistance to radiation |
Resistance to UV and gamma radiation CGSC |
||
|
ridA |
73.1 |
Rifampin dependence |
PMID:7035836[17] (rifampin and Kasugamycin dependence) |
Rifampin resistance and dependence CGSC |
|
|
ridB |
85.5 |
Rifampin dependence |
PMID:6757665[18] (Mutant is dependent on rifampin) |
Transcription and translation; rifampin (rifamycin) sensitivity CGSC |
rho |
|
rimB |
38.9 |
Ribosomal modification |
50S ribosomal subunit maturation CGSC |
||
|
rimC |
26.2 |
Ribosomal modification |
50S ribosomal subunit maturation CGSC |
||
|
rimD |
87.7 |
Ribosomal modification |
50S ribosomal subunit maturation CGSC |
||
|
rimE |
74.1 |
Ribosomal modification |
Ribosomal protein modification CGSC |
||
|
rimH |
13.6 |
Ribosomal modification |
stsB; ribosomal modification CGSC |
||
|
rit |
89.2 |
Ribosomal thermolability |
Affects thermolability of 50S ribosomal subunit CGSC |
||
|
rorB |
85.1 |
Roentgen resistance |
Sensitivity to ionizing radiation, mitomycin C CGSC |
||
|
sds |
30.4 |
Suppresses disulfide bond |
Motility defects CGSC |
||
|
semA |
40.5 |
Reduced sensitivity to microcin |
Sensitivity to microcin E492 CGSC |
Has been mapped near pabB gene | |
|
serR |
2.3 |
Serine |
Regulates level of seryl-tRNA synthetase CGSC |
||
|
sfiC |
25.8 |
Septum formation inhibition |
Element of e14, inhibitor of cell division CGSC |
||
|
sipC |
82.6 |
Suppressor of increased permeability |
Mutations reverse the susceptibility to vancomycin and other hydrophobic antibiotics caused by TraT plasmid gene CGSC |
||
|
sipD |
82.7 |
Suppressor of increased permeability |
Same phenotype as that produced by sipC CGSC |
||
|
sir |
61.2 |
SOS-independent repair |
SOS-independent repair of mitomycin C-induced DNA damage CGSC |
||
|
sloB |
75.0 |
Slow growth |
Tolerance for amidinopenicillin and nalidixic acid; slow growth rate CGSC |
||
|
slrR |
60.9 |
Sorbitol |
gutR; regulatory gene for srl CGSC |
||
|
srnA |
9.4 |
Stable RNA |
Degradation of stable RNA CGSC |
||
|
ssaE |
52.5 |
Suppression secA |
Suppresses secA mutations CGSC |
||
|
ssaG |
41.8 |
Suppression secA |
Suppresses secA mutations CGSC |
||
|
ssaH |
94.1 |
Suppression secA |
Suppresses secA mutations CGSC |
||
|
ssyD |
3.0 |
Suppression of secY |
Suppressor of secY mutation CGSC |
||
|
stfZ |
2.3 |
fts in reverse |
Antisense RNA blocks ftsZ mRNA translation, only inhibits cell division when overexpressed at high temperatures CGSC |
||
|
stkA |
77.5 |
Suppressor of transposase killing |
Suppresses cell aberrations and death caused by Tn5 transposase overexpression CGSC |
||
|
stkB |
86.1 |
Suppressor of transposase killing |
Suppresses cell aberrations and death caused by Tn5 transposase overexpression CGSC |
||
|
stkC |
98.5 |
Suppressor of transposase killing |
Suppresses cell aberrations and death caused by Tn5 transposase overexpression CGSC |
||
|
stkD |
28.6 |
Suppressor of transposase killing |
Suppresses cell aberrations and death caused by Tn5 transposase overexpression CGSC |
||
|
strC |
7.0 |
Streptomycin |
strB; low-level streptomycin resistance; modifies ribosome structure CGSC |
||
|
strM |
78.3 |
Streptomycin |
asuF?; control of ribosomal ambiguity CGSC |
||
|
stsA |
84.7 |
Altered RNase activity CGSC |
|||
|
suhA |
78.4 |
Suppressor heat-shock proteins |
Induction of heat shock genes CGSC |
||
|
tabC |
86.3 |
T4 abortion |
Mutants fail to support growth of T4 CGSC |
||
|
tanA |
41.6 |
Trehalose, anaerobic |
Anaerobic growth on trehalose CGSC |
||
|
tanB |
68.1 |
Trehalose, anaerobic |
Anaerobic growth on trehalose CGSC |
||
|
tdi |
4.3 |
Transduction inhibition |
Affects transduction, transformation, and rates of mutation CGSC |
||
|
thdA |
10.5 |
Thiophene degradation |
Degradation of furans and thiophenes; may be tlnA? CGSC |
||
|
psu |
1.3 min |
polarity suppressor |
|||
|
thdC |
94.2 |
Thiophene degradation |
Degradation of furans and thiophenes CGSC |
||
|
thdD |
99.8 |
Thiophene degradation |
Degradation of furans and thiophenes CGSC |
||
|
ackB |
39 min |
acetate kinase |
Ack- mutants were defective in aerobic growth on acetate or glucose as well as acetate accumulation from glucose & mapped near 39' (ackA mapped to ~50'). CGSC |
||
|
tlnA |
10.5 |
Thiolutin |
tlnI; resistance or sensitivity to thiolutin; may be thdA? CGSC |
||
|
alaB |
alanine-glutamate transaminase |
alaB was found to be capable of multi-copy suppression of an alanine auxotrophy. |
|||
|
tnm |
92.0 |
Tn migration |
Transposition of Tn9 and other transposons, development of phage Mu CGSC |
||
|
dgd |
D-galactose dehydrogenase |
||||
|
tolD |
22.9 |
Tolerance |
Bacteriocin tolerant; tolerance to colicins E2, E3, and ampicillin CGSC |
||
|
treE |
catabolic trehalose-6-phosphate phosphatase |
In the absence of osmotic stress, trehalose induces converstion to free glucose and a glucose polymer, in a pathway involving TreE. |
|||
|
tolE |
22.9 |
Tolerance |
Bacteriocin tolerant; tolerance to colicins E2, E3, and ampicillin CGSC |
||
|
tolI |
0.1 |
Tolerance |
Bacteriocin tolerant; sensitivity to colicins Ia and Ib CGSC |
||
|
tolJ |
0.1 |
Tolerance |
Bacteriocin tolerant; sensitivity to L, A, S4, E, and K CGSC |
||
|
tsmA |
40.1 |
Thymine suppression modifier |
Affects suppression efficiency for nonsense and frameshift mutations of Thy strains CGSC |
||
|
ups |
27.1 |
Up-suppression |
Increases efficiency of nonsense suppressors |
Proposed to be an allele of prfA[27] | |
|
uvh |
90.2 |
UV hyperresistant to UVC |
Resistance to UVC, peroxide and antibiotics; may affect SOS repair CGSC |
||
|
uvs |
91.1 |
UV sensitivity |
UV-sensitive mutants, locus linked to uvr CGSC |
||
|
adhB |
19.1 |
Alcohol dehydrogenase |
Alcohol dehydrogenase CGSC |
||
|
tlmR |
57.5 min |
Thiolactomycin resistance. |
|||
|
hipQ |
.7 minfrom the leu locus (2 min) |
Persistence |
High persistence mutation. |
| |
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Berlyn, MK (1998) Linkage map of Escherichia coli K-12, edition 10: the traditional map. Microbiol. Mol. Biol. Rev. 62 814-984 PubMed
- ↑ 2.0 2.1 Guardiola, J et al. (1974) Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12. J. Bacteriol. 117 393-405 PubMed
- ↑ Fayerman, JT et al. (1979) ilvU, a locus in Escherichia coli affecting the derepression of isoleucyl-tRNA synthetase and the RPC-5 chromatographic profiles of tRNAIle and tRNAVal. J. Biol. Chem. 254 9429-40 PubMed
- ↑ 4.0 4.1 Fouts, KE & Barbour, SD (1981) Transductional mapping of ksgB and a new Tn5-induced kasugamycin resistance gene, ksgD, in Escherichia coli K-12. J. Bacteriol. 145 914-9 PubMed
- ↑ Sparling, PF et al. (1973) Two genetic loci for resistance to kasugamycin in Escherichia coli. J. Bacteriol. 113 704-10 PubMed
- ↑ Yoshikawa, M et al. (1975) A third kasugamycin resistance locus, ksgC, affecting ribosomal protein S2 in Escherichia coli K-12. J. Bacteriol. 122 796-7 PubMed
- ↑ Wada, C et al. (1977) Replication of Fpoh+ plasmid in mafA mutants of Escherichia coli defective in plasmid maintenance. Mol. Gen. Genet. 152 211-7 PubMed
- ↑ 8.0 8.1 Wada, C & Yura, T (1979) Escherichia coli mutants incapable of supporting replication of F-like plasmids at high temperature: isolation and characterization of mafA and mafB mutants. J. Bacteriol. 140 864-73 PubMed
- ↑ Trun, NJ & Gottesman, S (1990) On the bacterial cell cycle: Escherichia coli mutants with altered ploidy. Genes Dev. 4 2036-47 PubMed
- ↑ Hane, MW & Wood, TH (1969) Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance studies. J. Bacteriol. 99 238-41 PubMed
- ↑ 11.0 11.1 Furukawa, H et al. (1993) Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB. J. Bacteriol. 175 3723-9 PubMed
- ↑ Cannon, M et al. (1974) Mapping of neamine resistance: identification to two genetic loci, nea A and nea B. Mol. Gen. Genet. 130 321-6 PubMed
- ↑ Delcuve, G et al. (1978) Resistance to the aminoglycoside antibiotic neamine in Escherichia coli. A new mutant whose NeaR phenotype results from the cumulative effects of two distinct mutations. Biochem. J. 174 1-7 PubMed
- ↑ Sastry, SS & Jayaraman, R (1984) Nitrofurantoin-resistant mutants of Escherichia coli: isolation and mapping. Mol. Gen. Genet. 196 379-80 PubMed
- ↑ Andrews, JC & Short, SA (1985) Genetic analysis of Escherichia coli oligopeptide transport mutants. J. Bacteriol. 161 484-92 PubMed
- ↑ 16.0 16.1 16.2 Wijsman, HJ & Pafort, HC (1974) Pleiotropic mutations in Escherichia coli conferring tolerance to glycine and sensitivity to penicillin. Mol. Gen. Genet. 128 349-57 PubMed
- ↑ Dabbs, ER & Looman, K (1981) An antibiotic dependent conditional lethal mutant with a lesion affecting transcription and translation. Mol. Gen. Genet. 184 224-9 PubMed
- ↑ 18.0 18.1 Dabbs, ER (1982) Three additional loci of rifampicin dependence in Escherichia coli. Mol. Gen. Genet. 187 519-22 PubMed
- ↑ Pugsley, AP et al. (1986) Microcin-E492-insensitive mutants of Escherichia coli K12. J. Gen. Microbiol. 132 3253-9 PubMed
- ↑ Maguin, E et al. (1986) Reversibility of SOS-associated division inhibition in Escherichia coli. J. Bacteriol. 166 733-8 PubMed
- ↑ Dewar, SJ & Donachie, WD (1993) Antisense transcription of the ftsZ-ftsA gene junction inhibits cell division in Escherichia coli. J. Bacteriol. 175 7097-101 PubMed
- ↑ Ephrati-Elizur, E (1993) A mutation in a new gene of Escherichia coli, psu, requires secondary mutations for survival: psu mutants express a pleiotropic suppressor phenotype. J. Bacteriol. 175 207-13 PubMed
- ↑ Pascal, MC et al. (1981) Mutants of Escherichia coli K12 with defects in anaerobic pyruvate metabolism. J. Gen. Microbiol. 124 35-42 PubMed
- ↑ Wang, MD et al. (1987) Cloning of genes that suppress an Escherichia coli K-12 alanine auxotroph when present in multicopy plasmids. J. Bacteriol. 169 5610-4 PubMed
- ↑ Strøm, AR & Kaasen, I (1993) Trehalose metabolism in Escherichia coli: stress protection and stress regulation of gene expression. Mol. Microbiol. 8 205-10 PubMed
- ↑ Davidoff-Abelson, R & Mindich, L (1978) A mutation that increases the activity of nonsense suppressors in Escherichia coli. Mol. Gen. Genet. 159 161-9 PubMed
- ↑ Riley, M (1993) Functions of the gene products of Escherichia coli. Microbiol. Rev. 57 862-952 PubMed
- ↑ 28.0 28.1 Ahmad, SI (1996) A mutant of Escherichia coli hyper-resistant to a number of DNA damaging agents: location of the mutational site. J. Photochem. Photobiol. B, Biol. 36 47-53 PubMed
- ↑ Wolfson, JS et al. (1990) Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents. Antimicrob. Agents Chemother. 34 1938-43 PubMed