hfq:Quickview: Difference between revisions

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Quickview

Standard Name	hfq
Gene Synonym(s)	ECK4168, b4172, JW4130, HF-I, HF-1^[1]^[2]
Product Desc.	RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins^[2]^[3]; Component of HF-I, host factor for RNA phage Q β replication^[3] Global regulator of sRNA function; host factor for RNA phage Q beta replication; HF-I; DNA- and RNA-binding protein; RNA chaperone; multiple regulatory roles: destabilzes ompA mRNA, improves rpoS translation, sRNA DsrA co-factor; binds RNAP; ATPase^[4]
Product Synonyms(s)	HF-I, host factor for RNA phage Q beta replication^[1], B4172^[2]^[1], Hfq^[2]^[1], HF-I^[2]^[1], host factor I^[2]^[1] , ECK4168, JW4130, b4172
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC^[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC
Regulation/Activity
Quick Links
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Notes

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The C-terminal of Hfq is not necessary for hexamerization. RNA binding is located primarily at the N-terminal. Hfq has intrinsic ATPase activity (Sukhodolets, 2003; Arluison, 2007).^[4]

Hfq enhances RNA-RNA pairing. ^[5]

References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ Zhang, A et al. (2002) The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs. Mol. Cell 9 11-22 PubMed

[LIB:Riley_2006-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)

[LIB:EcoCyc10.6-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

[LIB:EcoCyc11.1-3] 3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

[LIB:EcoGene-4] 4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.

[PMID:11804582-5] Zhang, A et al. (2002) The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs. Mol. Cell 9 11-22 PubMed

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[4]

[5]

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-{|{{Prettytable}}
+{|   id="G49aee8b7dd8ab"  class=" tableEdit New_Quickview_Table"
 |-
-!{{table_heading_style}} |Gene Name
+!align=left {{table_heading_style}} |Standard Name
-|
+||
-[[hfq:Gene|''hfq]]'' (synonyms: ''ECK4168, b4172, JW4130, HF-I, HF-1'')<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
+''hfq''
 |-
-!{{table_heading_style}} |Product(s)
+!align=left {{table_heading_style}} |Gene Synonym(s)
-|
+||
-[[hfq:Gene_Product(s)|Hfq product]]<ref name='LIB:Riley_2006'/>: HF-I, host factor for RNA phage Q beta replication product, B4172 product, HF-I product, host factor I product
+''ECK4168, b4172, JW4130, HF-I, HF-1''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
 |-
-!{{table_heading_style}} |Description
+!align=left {{table_heading_style}} |Product Desc.
-|
+||
-RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
+RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;
-Component of [[:Category:Complex:HF-I, host factor for RNA phage Q &beta; replication|HF-I, host factor for RNA phage Q &beta; replication]]<ref name='LIB:EcoCyc11.1'/>
+Component of [[:Category:Complex:HF-I, host factor for RNA phage Q beta replication|HF-I, host factor for RNA phage Q β replication]]<ref name='LIB:EcoCyc11.1'/>
+Global regulator of sRNA function; host factor for RNA phage Q beta replication; HF-I; DNA- and RNA-binding protein; RNA chaperone; multiple regulatory roles: destabilzes ompA mRNA, improves rpoS translation, sRNA DsrA co-factor; binds RNAP; ATPase<ref name='LIB:EcoGene'/>
+|-
+!align=left {{table_heading_style}} |Product Synonyms(s)
+||
+''HF-I, host factor for RNA phage Q beta replication<ref name='LIB:Riley_2006'/>, B4172<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hfq<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HF-I<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, host factor I<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4168, JW4130, b4172''
+|-
+!align=left {{table_heading_style}} |Function from GO
+||
+<GO_nr />
 |-
-!{{table_heading_style}} |Knock-Out Phenotype
+!align=left {{table_heading_style}} |Knock-Out Phenotype
-|
+||
 |-
-!{{table_heading_style}} |Regulation/Expression
+!align=left {{table_heading_style}} |Regulation/Expression
-|
+||
 transcription unit(s): [[:Category:Txn_unit:yjeFE-amiB-mutL-miaA-hfq-hflXKC|yjeFE-amiB-mutL-miaA-hfq-hflXKC]]<ref name='LIB:EcoCyc10.6'/>, ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC
 |-
-!{{table_heading_style}} |Regulation/Activity
+!align=left {{table_heading_style}} |Regulation/Activity
-|
+||
 |-
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+!align=left {{table_heading_style}} |Quick Links
+||
+[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=hfq&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10438]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000431&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=hfq&loc=MG1655%3A4398311..4398619,W3110%3A4404968..4405276,DH10B%3A4498673..4498981,REL606%3A4378443..4378751,BW2952%3A4337046..4337354]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4337046&end=4337354&gene=hfq&aa=makgqslqdpflnalrrervpvsiylvngiklqgqiesfdqfvillkntvsqmvykhaistvvpsrpvshhsnnagggtssnyhhgssaqntsaqqdseete]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=hfq+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=hfq]]&nbsp;&nbsp;
+|- class="tableEdit_footer"
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+The C-terminal of Hfq is not necessary for hexamerization.  RNA binding is located primarily at the N-terminal. Hfq has intrinsic ATPase activity (Sukhodolets, 2003; Arluison, 2007).<ref name='LIB:EcoGene'/>
+Hfq enhances RNA-RNA pairing. <ref name='PMID:11804582'/>
 <noinclude>
 ==References==
 {{BacktoTop}}
-{{RefHelp}}
 <references/>
 </noinclude>

hfq:Quickview: Difference between revisions

Latest revision as of 21:49, 27 May 2013

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