hfq:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
hfq |
|---|---|
| Gene Synonym(s) | |
| Product Desc. |
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins[2][3]; Component of HF-I, host factor for RNA phage Q β replication[3] Global regulator of sRNA function; host factor for RNA phage Q beta replication; HF-I; DNA- and RNA-binding protein; RNA chaperone; multiple regulatory roles: destabilzes ompA mRNA, improves rpoS translation, sRNA DsrA co-factor; binds RNAP; ATPase[4] |
| Product Synonyms(s) |
HF-I, host factor for RNA phage Q beta replication[1], B4172[2][1], Hfq[2][1], HF-I[2][1], host factor I[2][1] , ECK4168, JW4130, b4172 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC |
| Regulation/Activity | |
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Notes
The C-terminal of Hfq is not necessary for hexamerization. RNA binding is located primarily at the N-terminal. Hfq has intrinsic ATPase activity (Sukhodolets, 2003; Arluison, 2007).[4]
Hfq enhances RNA-RNA pairing. [5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Zhang, A et al. (2002) The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs. Mol. Cell 9 11-22 PubMed
