trpR:Gene Product(s): Difference between revisions

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|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Gene Product Resources|Resources]]
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|-
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!{{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
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TrpR product
TrpR
|-
|-
!{{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
|
||
DNA-binding transcriptional repressor, tryptophan-binding product<ref name='LIB:Riley_2006'/>, B4393 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RtrY product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TrpR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, regulator for trp operon and aroH; trp aporepressor product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''DNA-binding transcriptional repressor, tryptophan-binding <ref name='LIB:Riley_2006'/>, B4393 <ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RtrY <ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TrpR <ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, regulator for trp operon and aroH; trp aporepressor <ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4385, JW4356, b4393''
|-
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!{{table heading style}} |Product description
!align=left {{table heading style}} |Product description
|
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TrpR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
TrpR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  


Component of ; [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Autogenously regulated tryptophan repressor protein; regulator of trp operon, aroH, and other members of the TrpR regulon; 5-Methyltryptophan resistance<ref name='LIB:EcoGene'/>
|-
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!{{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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<protect><!--Nomenclature_notes--></protect>
<protect><!--Nomenclature_notes--></protect>
===Notes===
===Notes===
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{{BacktoTop}}
<protect>
<protect>
<big>'''Gene Ontology'''</big>
<big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.29544.T46ab32134d6b7-->
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="T46ab32134d6b7"  class=" tableEdit GO_table_product dataTable" 
|- {{table_heading_style}}
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!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
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|-  
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|
|
GO:0003677
|
|
GO:0006350
DNA binding
|
|
transcription
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
|
|
HAMAP:MF_00475
|
|
F
|
|
P
Seeded from [[EcoCyc]] (v14.0)
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
complete
|-
|
|
required fields missing 
 
|-
|
|
GO:0003677
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|
GO:0016564
DNA binding
|
|
transcription repressor activity
GOA:spkw<br />SP_KW:GO_REF:0000004
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|
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0238
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|
F
|
|
F
Seeded from [[EcoCyc]] (v14.0)
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
complete
|-
|
|
required fields missing 
 
|-
|
|
GO:0003700
|
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GO:0000162
transcription factor activity
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tryptophan biosynthetic process
GOA:interpro<br />GO_REF:0000002
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|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000831
|
|
F
|
|
P
Seeded from [[EcoCyc]] (v14.0)
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
complete
|-
|
|
required fields missing 
 
|-
|
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GO:0003700
|
|
GO:0005737
transcription factor activity
|
|
cytoplasm
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR013318
|
|
F
|
|
C
Seeded from [[EcoCyc]] (v14.0)
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
complete
|-
|
|
required fields missing 
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<span id="Interactions"></span><big>'''Interactions'''</big>
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!Partner Type!!Partner!!Notes
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Protein
GO:0005622
|
intracellular
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
|
Subunits of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]
InterPro:IPR013318
|
|
could be indirect 
C
|-
|
|
Protein
Seeded from [[EcoCyc]] (v14.0)
|
|
Subunits of [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]
complete
|-  
|
|
could be indirect 
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<!--Function_notes--></protect>
===Notes===


''trpR55'' is synonymous with ''trpR2,'' as studied by Yanofsky, et al, in 1984. <ref>http://cgsc2.biology.yale.edu/Mutation.php?ID=4525</ref>
|
GO:0005737
|
cytoplasm
|
GOA:hamap<br />GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00475
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
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''trpR2'' acts as a frameshift mutation within the ''trp'' repressor. As a result, the repressor remains inactive and is unable to bind to the operator of the ''trp'' operon, allowing transcription on the trp operon to proceed with tryptophan synthesis, instead of inhibiting production as it normally would in high levels of tryptophan. 
|
GO:0005737
|
cytoplasm
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|


''trpR2'' does not target a specific functional repressor, since levels of ''trp'' enzymes in strains with ''trpR2'' mutations do not differ from levels found within strains undergoing ''trpR'' amber and ''trpR'' deletion mutations. <ref name='PMID:6233264'/>
|
GO:0005737
|
cytoplasm
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0086
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|


Last updated 11/8/07 by user JHeyrman.
|
GO:0006350
|
transcription
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
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complete
|-
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==Localization==
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GO:0006355
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regulation of transcription, DNA-dependent
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GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR000831
!Compartment!!Description!!Evidence!!Notes
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P
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Seeded from [[EcoCyc]] (v14.0)
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complete
<protect><!--Localization_notes--></protect>
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===Notes===
|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR013318
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|


|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR013335
|
P
|
Seeded from [[EcoCyc]] (v14.0)
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complete
|-
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==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<span id="Sequence"></span><big>'''Physical Properties'''</big>
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!{{table heading style}} |Sequence
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[http://biocyc.org/ECOLI/sequence-aa?object=PD00423 at EcoCyc]
GO:0016564
<pre>MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
|
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD</pre>  
transcription repressor activity
|-
|
!{{table heading style}} |Mol. Wt
GOA:hamap<br />GO_REF:0000020
|
|
12.36 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
IEA: Inferred from Electronic Annotation
|-
!{{table heading style}} |pI
|
|
5.39<ref name='LIB:EcoCyc10.6'/>
HAMAP:MF_00475
|-
!{{table heading style}} |Extinction coefficient
|
|
13980 (calc based on 2 Y, 2 W, and 0 C residues)
F
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<big>'''Domains/Motifs/Modification Sites'''</big>
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!Type!!Residues!!Description!!Notes
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<span id="Structure"></span><big>'''Structure'''</big>
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!Structure Type!!Organism!!Accession!!Residues covered!!Notes
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X-RAY DIFFRACTION
Seeded from [[EcoCyc]] (v14.0)
|
|
Escherichia coli
complete
|-
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRO 1TRO] CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION
 
|
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GO:0016564
|
|
 
transcription repressor activity
|-
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|
NMR, 15 STRUCTURES
GOA:interpro<br />GO_REF:0000002
|
|
Escherichia coli
IEA: Inferred from Electronic Annotation
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RCS 1RCS] NMR STUDY OF TRP REPRESSOR-OPERATOR DNA COMPLEX
InterPro:IPR013335
|
|
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|-
|
|
X-RAY DIFFRACTION
complete
|-  
|
|
Escherichia coli
 
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MI7 1MI7] Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol
GO:0043565
|
|
sequence-specific DNA binding
|
|
 
GOA:interpro<br />GO_REF:0000002
|-
|
|
NMR, 15 STRUCTURES
IEA: Inferred from Electronic Annotation
|
|
Escherichia coli
InterPro:IPR010921
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CO0 1CO0] NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX
F
|
|
Seeded from [[EcoCyc]] (v14.0)
|
|
 
complete
|-
|-  
|
|
X-RAY DIFFRACTION
 
|
|
Escherichia coli
GO:0045892
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1P6Z 1P6Z] E. Coli Trp Apo-Repressor, Monoclinic Crystal Form
negative regulation of transcription, DNA-dependent
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|
GOA:hamap<br />GO_REF:0000020
|
|
 
IEA: Inferred from Electronic Annotation
|-
|
|
X-RAY DIFFRACTION
HAMAP:MF_00475
|
|
Escherichia coli
P
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3WRP 3WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
Seeded from [[EcoCyc]] (v14.0)
|
|
   
complete
 
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<span id="Interactions"></span><big>'''Interactions'''</big>
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!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
|
 
Protein
|-
|
|
Subunits of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]
|
|
could be indirect
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2WRP 2WRP]
 
|
|
   
   
|-
|
|
 
Protein
|-
|
|
NMR, 15 STRUCTURES
rpsC<br />
|
|
Escherichia coli
 
|
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[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRT 1WRT] NMR STUDY OF APO TRP REPRESSOR
PMID:16606699
|
|
Experiment(s):EBI-1147985<br />
|-
|
|
 
Protein
|-
|
|
NMR, 15 STRUCTURES
rnc<br />
|
|
Escherichia coli
 
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRS 1WRS] NMR STUDY OF HOLO TRP REPRESSOR
PMID:16606699
|
|
Experiment(s):EBI-1147985<br />
|-
|
|
 
Protein
|-
|
|
X-RAY DIFFRACTION
Subunits of [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]
|
|
Escherichia coli
could be indirect
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRP 1WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
 
|
|
   
   
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<!--Function_notes--></protect>
===Notes===
''trpR55'' is synonymous with ''trpR2,'' as studied by Yanofsky, et al, in 1984. <ref>http://cgsc2.biology.yale.edu/Mutation.php?ID=4525</ref>
''trpR2'' acts as a frameshift mutation within the ''trp'' repressor.  As a result, the repressor remains inactive and is unable to bind to the operator of the ''trp'' operon, allowing transcription on the trp operon to proceed with tryptophan synthesis, instead of inhibiting production as it normally would in high levels of tryptophan. 
''trpR2'' does not target a specific functional repressor, since levels of ''trp'' enzymes in strains with ''trpR2'' mutations do not differ from levels found within strains undergoing ''trpR'' amber and ''trpR'' deletion mutations.  <ref name='PMID:6233264'/>
==Localization==
<!--box uid=421aa90e079fa326b6494f812ad13e79.29544.F46ab3227a8d24-->
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!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
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<protect><!--Localization_notes--></protect>
===Notes===
==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<span id="Sequence"></span><big>'''Physical Properties'''</big>
<!--box uid=421aa90e079fa326b6494f812ad13e79.29544.O46ab3228dbb58-->
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{|  id="O46ab3228dbb58"  class=" tableEdit Product_phys_prop_table" 
|-
!align=left {{table heading style}} |Name
||
|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=PD00423 at EcoCyc]
<pre>MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD</pre>
|-
!align=left {{table heading style}} |Length
||
108
|-
!align=left {{table heading style}} |Mol. Wt
||
12.355 kDa
|-
!align=left {{table heading style}} |pI
||
5.3 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
13,980 (calc based on 2 Y, 2 W, and 0 C residues)
|- class="tableEdit_footer"
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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
<tr align="left" valign="top">
<td><!--box uid=421aa90e079fa326b6494f812ad13e79.29544.O46ab322963224-->
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|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
|
 
Initiator Methionine
|-
|
|
X-RAY DIFFRACTION
1
|
|
Escherichia coli
Removed
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRR 1TRR] TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX
[http://www.uniprot.org/uniprot/P0A881#section_features UniProt:P0A881]
|
|
   
   
|-
|
|
 
Domain
|-
|
|
X-RAY DIFFRACTION
17..104
|
|
Escherichia coli
[http://pfam.janelia.org/family/PF01371 PF01371 Trp repressor protein]
   
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG 1JHG] TRP REPRESSOR MUTANT V58I
 
|
|
PMID:19920124
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<motif_map/>
 
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</table>
 
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=trpR
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0A881 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0A881 PSI-PRED (P0A881)]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0A881 Genomes TO Protein (P0A881)] (GTOP)
 
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<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===


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===Notes===
===Notes===
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|- {{table_heading_style}}
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!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16132210 GI:16132210]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_418810.1 GeneID:948917]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0014408
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0A881 UniProtKB/Swiss-Prot:P0A881]
|
Escherichia coli str. K-12 substr. MG1655
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
[[EcoCyc]]
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00423 EcoCyc:PD00423] 
EcoCyc:EG11029
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
[[EcoGene]]
|
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A881 UniProt:P0A881] 
EcoGene:EG11029
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01371 PFAM:PF01371]
[http://www.ncbi.nlm.nih.gov/gene?term=948917 GeneID:948917]
|
|
Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418810 RefSeq:NP_418810] 
RegulonDB:ECK120001018
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG PDB:1JHG] 
EchoBASE:EB1022
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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===Notes===
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{{RefHelp}}
<references/>
<references />
__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0000162_!_tryptophan biosynthetic process]][[Category:GO:0005737_!_cytoplasm]][[Category:Complex:TrpR transcriptional repressor]][[Category:Complex:TrpR-Tryptophan transcriptional repressor]][[Category:Products with structures in PDB]]
[[Category:Proteins]]

Latest revision as of 21:16, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TrpR

Synonyms

DNA-binding transcriptional repressor, tryptophan-binding [1], B4393 [2][1], RtrY [2][1], TrpR [2][1], regulator for trp operon and aroH; trp aporepressor [2][1] , ECK4385, JW4356, b4393

Product description

TrpR[2][3];

Component of TrpR transcriptional repressor[2][3]; TrpR-Tryptophan transcriptional repressor[2][3]

Autogenously regulated tryptophan repressor protein; regulator of trp operon, aroH, and other members of the TrpR regulon; 5-Methyltryptophan resistance[4]

EC number (for enzymes)


edit table


Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00475

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000831

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013318

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013318

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00475

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000831

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013318

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013335

P

Seeded from EcoCyc (v14.0)

complete

GO:0016564

transcription repressor activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00475

F

Seeded from EcoCyc (v14.0)

complete

GO:0016564

transcription repressor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013335

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010921

F

Seeded from EcoCyc (v14.0)

complete

GO:0045892

negative regulation of transcription, DNA-dependent

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00475

P

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of TrpR transcriptional repressor

could be indirect

Protein

rpsC

PMID:16606699[5]

Experiment(s):EBI-1147985

Protein

rnc

PMID:16606699[5]

Experiment(s):EBI-1147985

Protein

Subunits of TrpR-Tryptophan transcriptional repressor

could be indirect


edit table


Notes

trpR55 is synonymous with trpR2, as studied by Yanofsky, et al, in 1984. [6]

trpR2 acts as a frameshift mutation within the trp repressor. As a result, the repressor remains inactive and is unable to bind to the operator of the trp operon, allowing transcription on the trp operon to proceed with tryptophan synthesis, instead of inhibiting production as it normally would in high levels of tryptophan.

trpR2 does not target a specific functional repressor, since levels of trp enzymes in strains with trpR2 mutations do not differ from levels found within strains undergoing trpR amber and trpR deletion mutations. [7]

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
edit table


Notes

Structure and Physical Properties

[back to top]


Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD
Length

108

Mol. Wt

12.355 kDa

pI

5.3 (calculated)

Extinction coefficient

13,980 (calc based on 2 Y, 2 W, and 0 C residues)

edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A881

Domain

17..104

PF01371 Trp repressor protein

PMID:19920124[8]

edit table

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=trpR taxon=562,83333 </beststructure>

Models

View models at:

edit table

Structure figures

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table


Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16132210

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948917

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0014408

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A881

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11029

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11029

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948917

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001018

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1022

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ http://cgsc2.biology.yale.edu/Mutation.php?ID=4525
  7. ↑ Yanofsky, C et al. (1984) Repression is relieved before attenuation in the trp operon of Escherichia coli as tryptophan starvation becomes increasingly severe. J. Bacteriol. 158 1018-24 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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