recA:Quickview: Difference between revisions

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{|   id="O49b021ebddde8"  class=" tableEdit New_Quickview_Table" 
 
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[recA:Gene|''recA]]'' (synonyms: ''ECK2694, b2699, JW2669, lexB, srf, umuB, zab, recH, rnmB, tif, umuR'')<ref name='LIB:Riley_2006'/>
''recA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[recA:Gene_Product(s)|RecA product]]<ref name='LIB:Riley_2006'/>: B2699 product, Tif product, UmuB product, Zab product, Srf product, RnmB product, RecH product, LexB product
''ECK2694, b2699, JW2669, lexB, srf, umuB, zab, recH, rnmB, tif, umuR''<ref name='LIB:Riley_2006'/>, umuR''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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DNA strand exchange and renaturation, DNA-dependent ATPase, DNA- and ATP-dependent coprotease<ref name='LIB:EcoCyc10.6'/> DNA strand exchange and recombination protein with protease and nuclease activity<ref name='LIB:EcoCyc11.1'/>  
DNA strand exchange and renaturation, DNA-dependent ATPase, DNA- and ATP-dependent coprotease<ref name='LIB:EcoCyc10.6'/>; DNA strand exchange and recombination protein with protease and nuclease activity<ref name='LIB:EcoCyc11.1'/>


General recombination and DNA repair; pairing and strand exchange; role in cleavage of LexA repressor, SOS mutagenesis<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''B2699<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Tif<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, UmuB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Zab<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Srf<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RnmB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LexB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2694, JW2669, lexB, recH, rnmB, srf, tif, umuB, umuR, zab, b2699''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:recAX|recAX]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:recA|recA]]<ref name='LIB:EcoCyc10.6'/>, OP00086  
transcription unit(s): [[:Category:Txn_unit:recAX|recAX]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:recA|recA]]<ref name='LIB:EcoCyc10.6'/>, OP00086  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=recA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10823]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000814&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=recA&loc=MG1655%3A2821791..2820730,W3110%3A2822425..2821364,REL606%3A2718628..2717567,BW2952%3A2706542..2707603]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2706542&end=2707603&gene=recA&aa=maidenkqkalaaalgqiekqfgkgsimrlgedrsmdvetistgslsldialgagglpmgriveiygpessgkttltlqviaaaqregktcafidaehaldpiyarklgvdidnllcsqpdtgeqaleicdalarsgavdvivvdsvaaltpkaeiegeigdshmglaarmmsqamrklagnlkqsntllifinqirmkigvmfgnpetttggnalkfyasvrldirrigavkegenvvgsetrvkvvknkiaapfkqaefqilygeginfygelvdlgvkekliekagawysykgekigqgkanatawlkdnpetakeiekkvrelllsnpnstpdfsvddsegvaetnedf]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=recA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=recA]]&nbsp;&nbsp;


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===Notes===
===Notes===
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RecA does not bind to DNA with extensive stem-loop structures, except in the presence of SSB.  RecA is required for polV lesion bypass. RecA filamentation is inhibited by RecX. Binds TrxA (Kumar, 2004).<ref name='LIB:EcoGene'/>
RecA lacking mutants exhibited the same frequency as the wild type when exposed to sublethal concentrations of the antibiotics Ampicillin, Ceftazidime, Imipenem, Fosfomycin, Ciprofloxacin, Trimethoprim, and Sulfamethoxazole.(PMID:21212055)
RecA lacking mutants exhibited different frequencies then the wild type when exposed to sublethal concentrations of the antibiotics Gentamicin, Rifampicin, Chloramphenicol (PMID:21212055)




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==References==
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Latest revision as of 21:43, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

recA

Gene Synonym(s)

ECK2694, b2699, JW2669, lexB, srf, umuB, zab, recH, rnmB, tif, umuR[1], umuR

Product Desc.

DNA strand exchange and renaturation, DNA-dependent ATPase, DNA- and ATP-dependent coprotease[2]; DNA strand exchange and recombination protein with protease and nuclease activity[3]

General recombination and DNA repair; pairing and strand exchange; role in cleavage of LexA repressor, SOS mutagenesis[4]

Product Synonyms(s)

B2699[2][1], Tif[2][1], UmuB[2][1], Zab[2][1], Srf[2][1], RnmB[2][1], RecH[2][1], LexB[2][1], RecA[2][1] , ECK2694, JW2669, lexB, recH, rnmB, srf, tif, umuB, umuR, zab, b2699

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): recAX[2], recA[2], OP00086

Regulation/Activity
Quick Links



        

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Notes

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RecA does not bind to DNA with extensive stem-loop structures, except in the presence of SSB. RecA is required for polV lesion bypass. RecA filamentation is inhibited by RecX. Binds TrxA (Kumar, 2004).[4]

RecA lacking mutants exhibited the same frequency as the wild type when exposed to sublethal concentrations of the antibiotics Ampicillin, Ceftazidime, Imipenem, Fosfomycin, Ciprofloxacin, Trimethoprim, and Sulfamethoxazole.(PMID:21212055)

RecA lacking mutants exhibited different frequencies then the wild type when exposed to sublethal concentrations of the antibiotics Gentamicin, Rifampicin, Chloramphenicol (PMID:21212055)



References

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  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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