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{{Tab On|Quickview|dnaA}}{{Tab|Gene|dnaA}}{{Tab|Gene Product(s)|dnaA}}{{Tab|Expression|dnaA}}{{Tab|Evolution|dnaA}}{{Tab|On One Page|dnaA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[dnaA:Gene|''dnaA]]'' (synonyms: ''ECK3694, b3702, JW3679'')<ref name='LIB:Riley_2006'/>
''dnaA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[dnaA:Gene_Product(s)|DnaA product]]<ref name='LIB:Riley_2006'/>: chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator<ref name='LIB:Riley_2006'/>, B3702<ref name='LIB:EcoCyc10.6'/>, DnaA<ref name='LIB:EcoCyc10.6'/>, DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator<ref name='LIB:EcoCyc10.6'/>
''ECK3694, b3702, JW3679''<ref name='LIB:Riley_2006'/>, JW3679''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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DnaA transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
DnaA transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
DNA synthesis initiator and global transcription regulator; binds DNA at DnaA boxes, binds cardiolipin and other acidic phospholipids, binds ATP<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator<ref name='LIB:Riley_2006'/>, B3702<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3694, JW3679, b3702''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:dnaAN-recF|dnaAN-recF]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:dnaAN-recF|dnaAN-recF]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=dnaA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10235]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000229&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=dnaA&loc=MG1655%3A3881752..3880349,W3110%3A3756686..3758089,REL606%3A3844090..3842687,BW2952%3A3768682..3770085]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3768682&end=3770085&gene=dnaA&aa=mslslwqqclarlqdelpatefsmwirplqaelsdntlalyapnrfvldwvrdkylnninglltsfcgadapqlrfevgtkpvtqtpqaavtsnvaapaqvaqtqpqraapstrsgwdnvpapaeptyrsnvnvkhtfdnfvegksnqlaraaarqvadnpggaynplflyggtglgkthllhavgngimarkpnakvvymhserfvqdmvkalqnnaieefkryyrsvdalliddiqffankersqeeffhtfnallegnqqiiltsdrypkeingvedrlksrfgwgltvaieppeletrvailmkkadendirlpgevaffiakrlrsnvrelegalnrviananftgraitidfvrealrdllalqeklvtidniqktvaeyykikvadllskrrsrsvarprqmamalakeltnhslpeigdafggrdhttvlhacrkieqlreeshdikedfsnlirtlss]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=dnaA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=dnaA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. Acidic phospholipids release bound ADP, reactivating DnaA by allowing ATP to rebind. Null mutations in seqA, yccV or rpoN suppress dna46(Ts).  Increases in DnaA levels reduce Fis oriC primary binding thus allowing DnaA to bind, this may play a role in the dynamics of prereplication complexes.  Collapsed replication forks (primarily within 10 map units of oriC) are a result of the level of initiation induced by elevated dnaA expression.  Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:55, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

dnaA

Gene Synonym(s)

ECK3694, b3702, JW3679[1], JW3679

Product Desc.

DnaA transcriptional dual regulator[2][3]

DNA synthesis initiator and global transcription regulator; binds DNA at DnaA boxes, binds cardiolipin and other acidic phospholipids, binds ATP[4]

Product Synonyms(s)

chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator[1], B3702[2][1], DnaA[2][1], DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator[2][1] , ECK3694, JW3679, b3702

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): dnaAN-recF[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. Acidic phospholipids release bound ADP, reactivating DnaA by allowing ATP to rebind. Null mutations in seqA, yccV or rpoN suppress dna46(Ts). Increases in DnaA levels reduce Fis oriC primary binding thus allowing DnaA to bind, this may play a role in the dynamics of prereplication complexes. Collapsed replication forks (primarily within 10 map units of oriC) are a result of the level of initiation induced by elevated dnaA expression. Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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