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{{Tab On|Quickview|mrcA}}{{Tab|Gene|mrcA}}{{Tab|Gene Product(s)|mrcA}}{{Tab|Expression|mrcA}}{{Tab|Evolution|mrcA}}{{Tab|On One Page|mrcA}}{{TabsBottom}}
{{Tab On|Quickview|mrcA}}{{Tab|Gene|mrcA}}{{Tab|Gene Product(s)|mrcA}}{{Tab|Expression|mrcA}}{{Tab|Evolution|mrcA}}{{Tab|On One Page|mrcA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[mrcA:Gene|''mrcA]]'' (synonyms: ''ECK3383, b3396, JW3359, ponA'')<ref name='LIB:Riley_2006'/>
''mrcA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[mrcA:Gene_Product(s)|MrcA product]]<ref name='LIB:Riley_2006'/>: fused penicillin-binding protein 1a: murein transglycosylase<ref name='LIB:Riley_2006'/>, murein transpeptidase<ref name='LIB:Riley_2006'/>, B3396<ref name='LIB:EcoCyc10.6'/>, PonA<ref name='LIB:EcoCyc10.6'/>, MrcA<ref name='LIB:EcoCyc10.6'/>, PBP1A<ref name='LIB:EcoCyc10.6'/>
''ECK3383, b3396, JW3359, ponA''<ref name='LIB:Riley_2006'/>, ponA''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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peptidoglycan synthetase; penicillin-binding protein 1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
peptidoglycan synthetase; penicillin-binding protein 1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''fused penicillin-binding protein 1a: murein transglycosylase<ref name='LIB:Riley_2006'/>, murein transpeptidase<ref name='LIB:Riley_2006'/>, B3396<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1A<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3383, JW3359, ponA, b3396''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:mrcA|mrcA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mrcA|mrcA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=mrcA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10748]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000739&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=mrcA&loc=MG1655%3A3520893..3523445,W3110%3A4117545..4114993,REL606%3A3451553..3454105,DH10B%3A3618638..3621190,BW2952%3A3408050..3410602]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3408050&end=3410602&gene=mrcA&aa=mklngkfpvkfvkyflilavccillgagsiyglyryiepqlpdvatlkdvrlqipmqiysadgeliaqygekrripvtldqippemvkafiatedsrfyehhgvdpvgifraasvalfsghasqgastitqqlarnfflspertlmrkikevflairieqlltkdeilelylnkiylgyraygvgaaaqvyfgktvdqltlnemaviaglpkapstfnplysmdravarrnvvlsrmldegyitqqqfdqtrteainanyhapeiafsapylsemvrqemynrygesayedgyriyttitrkvqqaaqqavrnnvldydmrhgyrgpanvlwkvgesawdnnkitdtlkalptygpllpaavtsanpqqatamladgstvalsmegvrwarpyrsdtqqgptprkvtdvlqtgqqiwvrqvgdawwlaqvpevnsalvsinpqngavmalvggfdfnqskfnratqalrqvgsnikpflytaamdkgltlasmlndvpisrwdasagsdwqpknsppqyagpirlrqglgqsknvvmvramramgvdyaaeylqrfgfpaqnivhteslalgsasftpmqvargyavmanggflvdpwfiskiendqggvifeakpkvacpecdipviygdtqksnvlenndvedvaisreqqnvsvpmpqleqanqalvaktgaqeyaphvintplafliksalntnifgepgwqgtgwragrdlqrrdiggktgttnsskdawfsgygpgvvtsvwigfddhrrnlghttasgaikdqisgyeggaksaqpawdaymkavlegvpeqpltpppgivtvnidrstgqlanggnsreeyfiegtqptqqavhevgttiidngeaqelf]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mrcA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=mrcA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Several phenotypes were associated with an mrcA deletion strain that inadvertantly deleted two neighboring genes, nudE(yrfE) and yrfF. One or both of these other genes turned out to be responsible for the observed mrcA-associated phenotypes.  Murein polymerase is an essential function satisfied by either MrcA or MrcB.  MrcA contains a PDZ domain involved in substrate recognition. MrcA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:47, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

mrcA

Gene Synonym(s)

ECK3383, b3396, JW3359, ponA[1], ponA

Product Desc.

peptidoglycan synthetase; penicillin-binding protein 1A[2][3]

Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric[4]

Product Synonyms(s)

fused penicillin-binding protein 1a: murein transglycosylase[1], murein transpeptidase[1], B3396[2][1], PonA[2][1], MrcA[2][1], PBP1A[2][1] , ECK3383, JW3359, ponA, b3396

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mrcA[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Several phenotypes were associated with an mrcA deletion strain that inadvertantly deleted two neighboring genes, nudE(yrfE) and yrfF. One or both of these other genes turned out to be responsible for the observed mrcA-associated phenotypes. Murein polymerase is an essential function satisfied by either MrcA or MrcB. MrcA contains a PDZ domain involved in substrate recognition. MrcA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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