msbA:Gene Product(s): Difference between revisions

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!align=left {{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
||
||
MsbA  
MsbA
fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
 
Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/>
 
 
 
 
 
 
 
 
 
 
|-
|-
!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
 
''fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ECK0905, JW0897, b0914''
|-
|-
!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
||
||
ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/>
|-
|-
!align=left {{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
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****************************************************************************************** -->{{Product_GO_help}}
****************************************************************************************** -->{{Product_GO_help}}
{|   id="B46aa4b479d593"  class=" tableEdit GO_table_product dataTable"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="B46aa4b479d593"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-  
|-  
|
|


GO:0005319
lipid transporter activity
GOA:hamap<br />GO_REF:0000020
IEA: Inferred from Electronic Annotation
HAMAP:MF_01703
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0005515
|
|
 
protein binding
|
|
 
PMID:18344567
|
|
 
IDA: Inferred from Direct Assay
|
|
 
 
|
|
 
F
|
|
 
 
|
|
complete
|-  
|-  
|
|


GO:0005524
ATP binding
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR001140
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0034040
|
|
 
lipid-transporting ATPase activity
|
|
 
PMID:18344567
|
|
 
IDA: Inferred from Direct Assay
|
|
 
 
|
|
 
F
|
|
 
 
|
|
complete
|-  
|-  
|
|


|
GO:0005524
GO:0005524
|
ATP binding
ATP binding
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR003439
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0067
|
|
 
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
 
|
 
|
|
complete
|-  
|-  
|
|


GO:0005524
ATP binding
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR011527
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0005886
|
|
 
plasma membrane
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0997
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0005524
ATP binding
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR011917
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0005886
|
|
 
plasma membrane
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-1003
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0005524
ATP binding
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR017871
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0006869
|
|
 
lipid transport
|
|
 
GOA:hamap<br />GO_REF:0000020
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
HAMAP:MF_01703
|
|
 
P
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0005524
ATP binding
GOA:spkw<br />SP_KW:GO_REF:0000004
IEA: Inferred from Electronic Annotation
SP_KW:KW-0067
F
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0006869
|
|
 
lipid transport
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR011917
|
|
 
P
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0005886
plasma membrane
GOA:spkw<br />SP_KW:GO_REF:0000004
IEA: Inferred from Electronic Annotation
SP_KW:KW-0997
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0006869
|
|
 
lipid transport
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0445
|
|
 
P
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0005886
plasma membrane
GOA:spkw<br />SP_KW:GO_REF:0000004
IEA: Inferred from Electronic Annotation
SP_KW:KW-1003
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0016020
|
|
 
membrane
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0472
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0006869
lipid transport
GOA:hamap<br />GO_REF:0000020
IEA: Inferred from Electronic Annotation
HAMAP:MF_01703
P
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0016020
|
|
 
membrane
|
|
 
PMID:16858726
|
|
 
IDA: Inferred from Direct Assay
|
|
 
 
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0006869
lipid transport
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR011917
P
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0016021
|
|
 
integral to membrane
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR001140
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0006869
lipid transport
GOA:spkw<br />SP_KW:GO_REF:0000004
IEA: Inferred from Electronic Annotation
SP_KW:KW-0445
P
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0016021
|
|
 
integral to membrane
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0812
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0016020
membrane
GOA:spkw<br />SP_KW:GO_REF:0000004
IEA: Inferred from Electronic Annotation
SP_KW:KW-0472
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0008289
|
|
 
lipid binding
|
|
 
PMID:18344567
|
|
 
IDA: Inferred from Direct Assay
|
|
 
 
|
|
 
F
|
|
 
 
|
|
complete
|-  
|-  
|
|


GO:0016020
membrane
PMID:16858726
IDA: Inferred from Direct Assay
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0016021
|
|
 
integral to membrane
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR011917
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
GO:0016021
GO:0016021
|
integral to membrane
integral to membrane
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR001140
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0812
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
 
|
 
|
|
complete
|-  
|-  
|
|


|
GO:0016021
GO:0016021
|
integral to membrane
integral to membrane
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR011527
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO_REF:0000023
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
SP_SL:SL-9909
|
|
 
C
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
 
complete
|
 
|
|-  
|-  
|
|


GO:0016021
integral to membrane
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR011917
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0055085
|
|
 
transmembrane transport
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR001140
|
|
 
P
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0005515
protein binding
PMID:18344567
IDA: Inferred from Direct Assay
C
complete
 
|
|
 
GO:0055085
|
|
 
transmembrane transport
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR011527
|
|
 
P
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0016021
integral to membrane
GOA:spkw<br />SP_KW:GO_REF:0000004
IEA: Inferred from Electronic Annotation
SP_KW:KW-0812
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0005319
|
|
 
lipid transporter activity
|
|
 
GOA:hamap<br />GO_REF:0000020
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
HAMAP:MF_01703
|
|
 
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0034040
lipid-transporting ATPase activity
PMID:18344567
IDA: Inferred from Direct Assay
F
complete
 
|
|
 
GO:0005524
|
|
 
ATP binding
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR001140
|
|
 
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0016021
integral to membrane
GO_REF:0000023
IEA: Inferred from Electronic Annotation
SP_SL:SL-9909
C
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0005524
|
|
 
ATP binding
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR003439
|
|
 
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0008289
lipid binding
PMID:18344567
IDA: Inferred from Direct Assay
F
complete
 
|
|
 
GO:0005524
|
|
 
ATP binding
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR011527
|
|
 
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0055085
transmembrane transport
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR001140
P
Seeded from [[EcoCyc]] (v14.0)
 
|
|
 
GO:0005524
|
|
 
ATP binding
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR011917
|
|
 
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


GO:0008144
drug binding
PMID:18344567
IDA: Inferred from Direct Assay
F
complete
 
|
|
 
GO:0005524
|
|
 
ATP binding
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR017871
|
|
 
F
|
 
|
|-
|
|
GO:0055085
transmembrane transport
GOA:interpro<br />GO_REF:0000002
IEA: Inferred from Electronic Annotation
InterPro:IPR011527
P
Seeded from [[EcoCyc]] (v14.0)
Seeded from [[EcoCyc]] (v14.0)
 
|
 
|
|
 
complete
|
 
|
 
|
 
|
 
|
 
|


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|<div class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21674.B46aa4b479d593&page=21674&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</div> || || || || || || || ||
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Line 1,379: Line 548:
*  
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****************************************************************************************** -->{{Product_interactions_help}}
****************************************************************************************** -->{{Product_interactions_help}}
{|   id="S46aa4b481bdb2"  class=" tableEdit Product_interactions_table dataTable"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="S46aa4b481bdb2"  class=" tableEdit Product_interactions_table dataTable"   
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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
Line 1,400: Line 569:
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****************************************************************************************** -->{{Product_localization_help}}
****************************************************************************************** -->{{Product_localization_help}}
{|   id="G46a7dd1c2b935"  class=" tableEdit Product_localization_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="G46a7dd1c2b935"  class=" tableEdit Product_localization_table"   
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!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-  
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plasma membrane
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
Daley et al. (2005) <ref name=PMID:15919996/>
|


 
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****************************************************************************************** -->{{Product_physical_properties_help}}
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{|  id="W46aa4b49d4e91"  class=" tableEdit Product_phys_prop_table"   
{|  id="W46aa4b49d4e91"  class=" tableEdit Product_phys_prop_table"   
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!align=left {{table heading style}} |Name
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Line 1,467: Line 624:
LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL
LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ</pre>  
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ</pre>
582
64.462 kDa
8.8 (calculated)
46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues)
 
 
 
 
 
 
 
 
 
 
 
 
|-
|-
!align=left {{table heading style}} |Length
!align=left {{table heading style}} |Length
||
||
 
582
|-
|-
!align=left {{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
 
64.462 kDa
|-
|-
!align=left {{table heading style}} |pI
!align=left {{table heading style}} |pI
||
||
 
8.8 (calculated)
|-
|-
!align=left {{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
 
46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues)


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****************************************************************************************** -->{{Product_domains_motifs_help}}
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{|   id="M46aa4b4a3c914"  class=" tableEdit Product_motif_table dataTable"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="M46aa4b4a3c914"  class=" tableEdit Product_motif_table dataTable"   
|- {{table heading style}}
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!|Type!!Residues!!Description!!Notes!!References
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
24..298
|
[http://pfam.janelia.org/family/PF00664 PF00664  ABC transporter transmembrane region]
|
|
PMID:19920124
|-
|
Domain
|
383..509
|
[http://pfam.janelia.org/family/PF00005 PF00005  ABC transporter]
|
|
PMID:19920124


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taxon=562,83333
taxon=562,83333
</beststructure>
</beststructure>
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
 
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P60752 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P60752 PSI-PRED (P60752)]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P60752 Genomes TO Protein (P60752)] (GTOP)


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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10613-MONOMER EcoCyc:EG10613-MONOMER]
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[http://www.ncbi.nlm.nih.gov/protein/16128881 GI:16128881]
 
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Escherichia coli str. K-12 substr. MG1655
 
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[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
 
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[http://www.ncbi.nlm.nih.gov/protein/NP_415434.1 GeneID:945530]
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Escherichia coli str. K-12 substr. MG1655
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[[ASAP]]
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ASAP:ABE-0003113
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.uniprot.org/uniprot/P60752 UniProtKB/Swiss-Prot:P60752]
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Escherichia coli str. K-12 substr. MG1655
|-  
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[[EcoCyc]]
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EcoCyc:EG10613
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[[EcoGene]]
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EcoGene:EG10613
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
[[uniprot:P60752|UniProt:P60752]]
 
 
 
 
 
 
 
|
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[http://www.ncbi.nlm.nih.gov/gene?term=945530 GeneID:945530]
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Escherichia coli str. K-12 substr. MG1655
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
[http://pfam.sanger.ac.uk/family?acc=PF00664 PFAM:PF00664]
 
 
 
 
 
 
 
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RegulonDB:ECK120000606
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415434 RefSeq:NP_415434]
 
 
 
 
 
 
 
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EchoBASE:EB0608
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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{{BacktoTop}}
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[[Category:Proteins]]
[[Category:Proteins]]
[[Category:RefGenome_Annotated_Gene]]
[[Category:Pfam:PF00664_!_ABC transporter transmembrane region]]
[[Category:Pfam:PF00005_!_ABC transporter]]
[[Category:RefGenome_Annotated_Gene]]
[[Category:RefGenome_Annotated_Gene]]

Latest revision as of 20:54, 6 July 2021

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MsbA

Synonyms

fused lipid transporter subunits of ABC superfamily: membrane component[1], ATP-binding component[1], B0914[2][1], MsbA[2][1], ECK0905, JW0897, b0914

Product description

ATP-binding transport protein[2][3]

Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

PMID:18344567[5]

IDA: Inferred from Direct Assay

F

complete

GO:0034040

lipid-transporting ATPase activity

PMID:18344567[5]

IDA: Inferred from Direct Assay

F

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006869

lipid transport

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01703

P

Seeded from EcoCyc (v14.0)

complete

GO:0006869

lipid transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

P

Seeded from EcoCyc (v14.0)

complete

GO:0006869

lipid transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0445

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[6]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0008289

lipid binding

PMID:18344567[5]

IDA: Inferred from Direct Assay

F

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0055085

transmembrane transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140

P

Seeded from EcoCyc (v14.0)

complete

GO:0055085

transmembrane transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

P

Seeded from EcoCyc (v14.0)

complete

GO:0005319

lipid transporter activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01703

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017871

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 6 predicted transmembrane domains

Daley et al. (2005) [7]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD
RSVLVWMPLV VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS
TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI
AIRVVSKRFR NISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ
GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS
LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT YPGRDVPALR
NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA
LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ
Length

582

Mol. Wt

64.462 kDa

pI

8.8 (calculated)

Extinction coefficient

46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

24..298

PF00664 ABC transporter transmembrane region

PMID:19920124[8]

Domain

383..509

PF00005 ABC transporter

PMID:19920124[8]

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<motif_map/>

tmhmm.php?gene=msbA&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=msbA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128881

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945530

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003113

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P60752

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10613

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10613

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945530

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000606

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0608

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Eckford, PD & Sharom, FJ (2008) Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. J. Biol. Chem. 283 12840-50 PubMed
  6. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  7. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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