copA:Gene Product(s): Difference between revisions

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*  
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****************************************************************************************** -->{{Product_nomenclature_help}}
****************************************************************************************** -->{{Product_nomenclature_help}}
{|  id="R46aa32c577309"  class=" tableEdit Product_nomenclature_table"   
{| {{Prettytable}} id="R46aa32c577309"  class=" tableEdit Product_nomenclature_table"   


|-
|-
!align=left |Standard name
!align=left {{table heading style}} |Standard name
||
||
CopA  
CopA  
|-
|-
!align=left |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
copper transporter<ref name='LIB:Riley_2006'/>, B0484<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CopA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''copper transporter<ref name='LIB:Riley_2006'/>, B0484<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CopA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0478, JW0473, ybaR, b0484''
|-
|-
!align=left |Product description
!align=left {{table heading style}} |Product description
||
||
YbaR<ref name='LIB:EcoCyc10.6'/>; Cu<sup>+</sup>-exporting ATPase<ref name='LIB:EcoCyc11.1'/>
YbaR<ref name='LIB:EcoCyc10.6'/>; Cu<sup>+</sup>-exporting ATPase<ref name='LIB:EcoCyc11.1'/>
Line 52: Line 52:
Copper-, silver-translocating P-type ATPase efflux pump; involved in copper resistance; copper- and silver-inducible; regulated by copper-responsive CueR activator<ref name='LIB:EcoGene'/>
Copper-, silver-translocating P-type ATPase efflux pump; involved in copper resistance; copper- and silver-inducible; regulated by copper-responsive CueR activator<ref name='LIB:EcoGene'/>
|-
|-
!align=left |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
||
||
[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4]<ref name='LIB:Riley_2006'/>
[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4]<ref name='LIB:Riley_2006'/>
Line 75: Line 75:
*  
*  
****************************************************************************************** -->{{Product_GO_help}}
****************************************************************************************** -->{{Product_GO_help}}
{|   id="G46aa32c670c12"  class=" tableEdit GO_table_product dataTable"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="G46aa32c670c12"  class=" tableEdit GO_table_product dataTable"   
|-
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0031224
|
intrinsic to membrane
|
PMID:12351646
|
IDA: Inferred from Direct Assay
|
 
|
C
|
Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
 
CopA was purified from everted membrane vesicles (Fig. 6).
|
complete
|-  
|-  
|
|


|
|
GO:0004008
GO:0015662
|
|
copper-exporting ATPase activity
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
|
|
GO_REF:0000002<br />GO_REF:0000003
PMID:11167016
|
|
IEA: Inferred from Electronic Annotation
IDA: Inferred from Direct Assay
|
|
InterPro:IPR006403<br />EC:3.6.3.4
 
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Figure 2
|
|
complete  
complete  
Line 101: Line 122:


|
|
GO:0005375
GO:0015662
|
|
copper ion transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
|
|
GO_REF:0000004
PMID:12351646
|
|
IEA: Inferred from Electronic Annotation
IDA: Inferred from Direct Assay
|
|
SP_KW:KW-0187
 
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 
|
complete
|-
|
 
|
GO:0006825
|
copper ion transport
|
PMID:10639134
|
IMP: Inferred from Mutant Phenotype
|
 
|
P
|
Everted membrane vesicles prepared from a Δ''copA'' strain that expressed ''copA'' from a plasmid accumulated <sup>64</sup>Cu.  Accumulation required ATP.
|
|
complete  
complete  
Line 120: Line 160:


|
|
GO:0003824
GO:0043682
|
|
catalytic activity
copper-transporting ATPase activity
|
|
GO_REF:0000002
 
|
|
IEA: Inferred from Electronic Annotation
 
|
|
InterPro:IPR005834
 
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
 
|
Missing: evidence, reference
|-
|
 
|
GO:0016021
|
integral to membrane
|
PMID:11152613
|
ISM: Inferred from Sequence Model
|
 
|
C
|
Predicted transmembrane domains shown below in the table of Domains/Motifs/Modification sites.
|
Missing: with/from  
|-
|
 
|
GO:0010273
|
detoxification of copper ion
|
PMID:10639134
|
IMP: Inferred from Mutant Phenotype
|
 
|
P
|
''copA'' mutants are sensitive to copper ions.
|
|
complete  
complete  
Line 139: Line 217:


|
|
GO:0000287
GO:0016887
|
|
magnesium ion binding
ATPase activity
|
|
GO_REF:0000004
PMID:12351646
|
|
IEA: Inferred from Electronic Annotation
IDA: Inferred from Direct Assay
|
|
SP_KW:KW-0460
 
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Fig. 6 shows ATPase activity of CopA purified from membrane vesicles.
|
|
complete  
complete  
Line 162: Line 240:
nucleotide binding
nucleotide binding
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 170: Line 248:
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 177: Line 255:


|
|
GO:0016020
GO:0000287
|
|
membrane
magnesium ion binding
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR008250<br />SP_KW:KW-0472
SP_KW:KW-0460
|
|
C
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 196: Line 274:


|
|
GO:0015992
GO:0004008
|
|
proton transport
copper-exporting ATPase activity
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000695
InterPro:IPR006403
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 219: Line 297:
copper ion binding
copper ion binding
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 227: Line 305:
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 238: Line 316:
ATP binding
ATP binding
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR008250<br />SP_KW:KW-0067
InterPro:IPR000695
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 253: Line 331:


|
|
GO:0006810
GO:0005524
|
|
transport
ATP binding
|
|
GO_REF:0000002<br />GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR001757<br />SP_KW:KW-0813
InterPro:IPR001757
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 272: Line 350:


|
|
GO:0006811
GO:0005524
|
|
ion transport
ATP binding
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0406
InterPro:IPR006403
|
|
P
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 291: Line 369:


|
|
GO:0006825
GO:0005524
|
|
copper ion transport
ATP binding
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0187
InterPro:IPR008250
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 310: Line 388:


|
|
GO:0008152
GO:0005524
|
|
metabolic process
ATP binding
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR005834
InterPro:IPR018303
|
|
P
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 329: Line 407:


|
|
GO:0015662
GO:0005524
|
|
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
ATP binding
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006416
SP_KW:KW-0067
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 348: Line 426:


|
|
GO:0016021
GO:0005886
|
|
integral to membrane
plasma membrane
|
|
GO_REF:0000002<br />GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR006416<br />SP_KW:KW-0812
SP_KW:KW-1003
|
|
C
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0006754
|
ATP biosynthetic process
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000695
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 367: Line 464:


|
|
GO:0016787
GO:0006754
|
|
hydrolase activity
ATP biosynthetic process
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0378
InterPro:IPR001757
|
|
F
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 386: Line 483:


|
|
GO:0046873
GO:0006754
|
|
metal ion transmembrane transporter activity
ATP biosynthetic process
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 396: Line 493:
InterPro:IPR006403
InterPro:IPR006403
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 405: Line 502:


|
|
GO:0016820
GO:0006754
|
|
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
ATP biosynthetic process
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR008250
InterPro:IPR006416
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 424: Line 521:


|
|
GO:0030001
GO:0006754
|
|
metal ion transport
ATP biosynthetic process
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR006121<br />InterPro:IPR006403<br />InterPro:IPR006416
InterPro:IPR008250
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 443: Line 540:


|
|
GO:0046872
GO:0006754
|
|
metal ion binding
ATP biosynthetic process
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR006121<br />InterPro:IPR006403<br />SP_KW:KW-0479
InterPro:IPR018303
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 462: Line 559:


|
|
GO:0031224
GO:0006825
|
|
intrinsic to membrane
copper ion transport
|
|
PMID:12351646
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0187
|
|
C
P
|
|
Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
Seeded from [[EcoCyc]] (v14.0)
 
CopA was purified from everted membrane vesicles (Fig. 6).
|
|
complete  
complete  
Line 483: Line 578:


|
|
GO:0005886
GO:0008152
|
|
plasma membrane
metabolic process
|
|
GO_REF:0000004<br />GO_REF:0000023
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-1003<br />SP_SL:SL-0039
InterPro:IPR000150
|
|
C
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 502: Line 597:


|
|
GO:0006754
GO:0008152
|
|
ATP biosynthetic process
metabolic process
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR006416<br />InterPro:IPR008250
InterPro:IPR005834
|
|
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
|
GO:0015662  
GO:0015662
|
|
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
|
|
PMID:11167016
GOA:interpro<br />GO_REF:0000002
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000695
|
|
F
F
|
|
Figure 2
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
|
GO:0015662
GO:0015662
Line 544: Line 639:
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
|
|
PMID:12351646
GOA:interpro<br />GO_REF:0000002
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR001757
|
|
F
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 559: Line 654:


|
|
GO:0006825
GO:0015662
|
|
copper ion transport
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
|
|
PMID:10639134
GOA:interpro<br />GO_REF:0000002
|
|
IMP: Inferred from Mutant Phenotype
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR006416
|
|
P
F
|
|
Everted membrane vesicles prepared from a Δ''copA'' strain that expressed ''copA'' from a plasmid accumulated <sup>64</sup>Cu.  Accumulation required ATP.
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 578: Line 673:


|
|
GO:0043682
GO:0015662
|
|
copper-transporting ATPase activity
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
|
|
 
GOA:interpro<br />GO_REF:0000002
|
|
 
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR018303
|
|
F
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
|


|
|
required field missing
GO:0016021
|
integral to membrane
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006416
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-  
|-  
|
|
Line 601: Line 715:
integral to membrane
integral to membrane
|
|
PMID:11152613
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
|
ISM: Inferred from Sequence Model
complete
|-
|
|


|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9909
|
|
C
C
|
|
Predicted transmembrane domains shown below in the table of Domains/Motifs/Modification sites.
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 616: Line 749:


|
|
GO:0010273
GO:0046872
|
metal ion binding
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006121
|
|
detoxification of copper ion
F
|
|
PMID:10639134
Seeded from [[EcoCyc]] (v14.0)
|
|
IMP: Inferred from Mutant Phenotype
complete
|-
|
|


|
|
P
GO:0046872
|
metal ion binding
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR017969
|
F
|
|
''copA'' mutants are sensitive to copper ions.
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 635: Line 787:


|
|
GO:0016887
GO:0046872
|
|
ATPase activity
metal ion binding
|
|
PMID:12351646
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0479
|
|
F
F
|
|
Fig. 6 shows ATPase activity of CopA purified from membrane vesicles.
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-  
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!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
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|-
!align=left {{table heading style}} |Name
||


|-
|-
!align=left |Sequence
!align=left {{table heading style}} |Sequence
||
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6260-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=G6260-MONOMER at EcoCyc]  
Line 819: Line 975:
AFIYNSIGIP VAAGILWPFT GTLLNPVVAG AAMALSSITV VSNANRLLRF KPKE</pre>  
AFIYNSIGIP VAAGILWPFT GTLLNPVVAG AAMALSSITV VSNANRLLRF KPKE</pre>  
|-
|-
!align=left |Length
!align=left {{table heading style}} |Length
||
||
834
834
|-
|-
!align=left |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
87.872 kDa
87.872 kDa
|-
|-
!align=left |pI
!align=left {{table heading style}} |pI
||
||
5.4 (calculated)
5.4 (calculated)
|-
|-
!align=left |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
69,900 - 70,650 (calc based on 10 Y, 10 W, and 6 C residues)
69,900 - 70,650 (calc based on 10 Y, 10 W, and 6 C residues)
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{|   id="M46aa32cf0cf93"  class=" tableEdit Product_motif_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="M46aa32cf0cf93"  class=" tableEdit Product_motif_table dataTable"   
|-
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-  
|-  
|
|
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Removed
Removed
|
|
[http://www.uniprot.org/uniprot/Q59385#section_features UniProt:Q59385]  
[http://www.uniprot.org/uniprot/Q59385#section_features UniProt:Q59385]
|
|-
|
Domain
|
6..62
|
[http://pfam.janelia.org/family/PF00403 PF00403  Heavy-metal-associated domain]
|
 
|
PMID:19920124
|-
|
Domain
|
102..160
|
[http://pfam.janelia.org/family/PF00403 PF00403  Heavy-metal-associated domain]
|
 
|
PMID:19920124
|-
|
Domain
|
517..732
|
[http://pfam.janelia.org/family/PF00702 PF00702  haloacid dehalogenase-like hydrolase]
|
 
|
PMID:19920124
|-
|
Domain
|
291..513
|
[http://pfam.janelia.org/family/PF00122 PF00122  E1-E2 ATPase]
|
 
|
PMID:19920124


|- class="tableEdit_footer"  
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|-
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!align=left |Structures
!align=left {{table heading style}} |Structures
||
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<beststructure>
<beststructure>
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</beststructure>
|-
|-
!align=left |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/Q59385 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=Q59385 PSI-PRED (Q59385)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=Q59385 Genomes TO Protein (Q59385)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="J46aa32cfecb2f"  class=" tableEdit Gene_accessions_table"   
|-
|- {{table_heading_style}}
!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-  
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128468 GI:16128468]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415017.1 GeneID:946106]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0001681
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/Q59385 UniProtKB/Swiss-Prot:Q59385]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[EcoCyc]]
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6260-MONOMER EcoCyc:G6260-MONOMER]
EcoCyc:G6260
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|-  
|
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
[[EcoGene]]
|
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=Q59385 SwissModel:Q59385]
EcoGene:EG13246
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|-  
|
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[[uniprot:Q59385|UniProt:Q59385]]
[http://www.ncbi.nlm.nih.gov/gene?term=946106 GeneID:946106]
|
|
Escherichia coli str. K-12 substr. MG1655
|-  
|-  
|
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://pfam.sanger.ac.uk/family?acc=PF00403 PFAM:PF00403]
RegulonDB:ECK120002868
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|-  
|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415017 RefSeq:NP_415017]
EchoBASE:EB3035
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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{{BacktoTop}}
{{BacktoTop}}
[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0016021_!_integral to membrane]][[Category:GO:0015662_!_ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism]]
[[Category:RefGenome_Annotated_Gene]]
[[Category:RefGenome_Annotated_Gene]]
[[Category:RefGenome_Annotated_Gene]]
[[Category:RefGenome_Annotated_Gene]]

Latest revision as of 20:26, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CopA

Synonyms

copper transporter[1], B0484[2][1], YbaR[2][1], CopA[2][1] , ECK0478, JW0473, ybaR, b0484

Product description

YbaR[2]; Cu+-exporting ATPase[3]

Copper-, silver-translocating P-type ATPase efflux pump; involved in copper resistance; copper- and silver-inducible; regulated by copper-responsive CueR activator[4]

EC number (for enzymes)

3.6.3.4[1]

edit table


Notes

Function

[back to top]


Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031224

intrinsic to membrane

PMID:12351646[5]

IDA: Inferred from Direct Assay

C

Seeded from Riley et al 2006 [1].

CopA was purified from everted membrane vesicles (Fig. 6).

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

PMID:11167016[6]

IDA: Inferred from Direct Assay

F

Figure 2

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

PMID:12351646[5]

IDA: Inferred from Direct Assay

F

complete

GO:0006825

copper ion transport

PMID:10639134[7]

IMP: Inferred from Mutant Phenotype

P

Everted membrane vesicles prepared from a ΔcopA strain that expressed copA from a plasmid accumulated 64Cu. Accumulation required ATP.

complete

GO:0043682

copper-transporting ATPase activity

F

Missing: evidence, reference

GO:0016021

integral to membrane

PMID:11152613[8]

ISM: Inferred from Sequence Model

C

Predicted transmembrane domains shown below in the table of Domains/Motifs/Modification sites.

Missing: with/from

GO:0010273

detoxification of copper ion

PMID:10639134[7]

IMP: Inferred from Mutant Phenotype

P

copA mutants are sensitive to copper ions.

complete

GO:0016887

ATPase activity

PMID:12351646[5]

IDA: Inferred from Direct Assay

F

Fig. 6 shows ATPase activity of CopA purified from membrane vesicles.

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0004008

copper-exporting ATPase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006403

F

Seeded from EcoCyc (v14.0)

complete

GO:0005507

copper ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0186

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000695

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006403

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008250

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018303

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006754

ATP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000695

P

Seeded from EcoCyc (v14.0)

complete

GO:0006754

ATP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

P

Seeded from EcoCyc (v14.0)

complete

GO:0006754

ATP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006403

P

Seeded from EcoCyc (v14.0)

complete

GO:0006754

ATP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006416

P

Seeded from EcoCyc (v14.0)

complete

GO:0006754

ATP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008250

P

Seeded from EcoCyc (v14.0)

complete

GO:0006754

ATP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018303

P

Seeded from EcoCyc (v14.0)

complete

GO:0006825

copper ion transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0187

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000150

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005834

P

Seeded from EcoCyc (v14.0)

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000695

F

Seeded from EcoCyc (v14.0)

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

F

Seeded from EcoCyc (v14.0)

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006416

F

Seeded from EcoCyc (v14.0)

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018303

F

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006416

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006121

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017969

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

sdhA

PMID:16606699[9]

Experiment(s):EBI-1136866

Protein

glpD

PMID:16606699[9]

Experiment(s):EBI-1136866

Protein

ydcD

PMID:16606699[9]

Experiment(s):EBI-1136866

Protein

dnaK

PMID:16606699[9]

Experiment(s):EBI-1136866

Protein

groL

PMID:16606699[9]

Experiment(s):EBI-1136866

Protein

hflB

PMID:16606699[9]

Experiment(s):EBI-1136866
edit table


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 8 predicted transmembrane domains

Daley et al. (2005) [10]

Inner Membrane

PMID:10639134[7]

EchoLocation:copA


edit table


Notes

Structure and Physical Properties

[back to top]


Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VEQADVSITE AHVTGTASAE QLIETIKQAG
YDASVSHPKA KPLAESSIPS EALTAVSEAL PAATADDDDS QQLLLSGMSC ASCVTRVQNA
LQSVPGVTQA RVNLAERTAL VMGSASPQDL VQAVEKAGYG AEAIEDDAKR RERQQETAVA
TMKRFRWQAI VALAVGIPVM VWGMIGDNMM VTADNRSLWL VIGLITLAVM VFAGGHFYRS
AWKSLLNGAA TMDTLVALGT GVAWLYSMSV NLWPQWFPME ARHLYYEASA MIIGLINLGH
MLEARARQRS SKALEKLLDL TPPTARLVTD EGEKSVPLAE VQPGMLLRLT TGDRVPVDGE
ITQGEAWLDE AMLTGEPIPQ QKGEGDSVHA GTVVQDGSVL FRASAVGSHT TLSRIIRMVR
QAQSSKPEIG QLADKISAVF VPVVVVIALV SAAIWYFFGP APQIVYTLVI ATTVLIIACP
CALGLATPMS IISGVGRAAE FGVLVRDADA LQRASTLDTV VFDKTGTLTE GKPQVVAVKT
FADVDEAQAL RLAAALEQGS SHPLARAILD KAGDMQLPQV NGFRTLRGLG VSGEAEGHAL
LLGNQALLNE QQVGTKAIEA EITAQASQGA TPVLLAVDGK AVALLAVRDP LRSDSVAALQ
RLHKAGYRLV MLTGDNPTTA NAIAKEAGID EVIAGVLPDG KAEAIKHLQS EGRQVAMVGD
GINDAPALAQ ADVGIAMGGG SDVAIETAAI TLMRHSLMGV ADALAISRAT LHNMKQNLLG
AFIYNSIGIP VAAGILWPFT GTLLNPVVAG AAMALSSITV VSNANRLLRF KPKE
Length

834

Mol. Wt

87.872 kDa

pI

5.4 (calculated)

Extinction coefficient

69,900 - 70,650 (calc based on 10 Y, 10 W, and 6 C residues)

edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:Q59385

Domain

6..62

PF00403 Heavy-metal-associated domain

PMID:19920124[11]

Domain

102..160

PF00403 Heavy-metal-associated domain

PMID:19920124[11]

Domain

517..732

PF00702 haloacid dehalogenase-like hydrolase

PMID:19920124[11]

Domain

291..513

PF00122 E1-E2 ATPase

PMID:19920124[11]

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<motif_map/>

tmhmm.php?gene=copA&show=pic&.jpg
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Structure
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Structures

<beststructure> gene=copA taxon=562,83333 </beststructure>

Models

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Structure figures

Notes

Gene Product Resources

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Resource type Source Notes/Reference

Purification protocol

PMID:12351646[5]


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Notes

Accessions in Other Databases

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Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128468

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946106

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001681

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:Q59385

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6260

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13246

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946106

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002868

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3035

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Fan, B & Rosen, BP (2002) Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase. J. Biol. Chem. 277 46987-92 PubMed
  6. ↑ Petersen, C & Møller, LB (2000) Control of copper homeostasis in Escherichia coli by a P-type ATPase, CopA, and a MerR-like transcriptional activator, CopR. Gene 261 289-98 PubMed
  7. ↑ 7.0 7.1 7.2 Rensing, C et al. (2000) CopA: An Escherichia coli Cu(I)-translocating P-type ATPase. Proc. Natl. Acad. Sci. U.S.A. 97 652-6 PubMed
  8. ↑ Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  11. ↑ 11.0 11.1 11.2 11.3 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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