copA:Gene Product(s): Difference between revisions

Standard name	CopA
Synonyms	copper transporter^[1], B0484^[2]^[1], YbaR^[2]^[1], CopA^[2]^[1] , ECK0478, JW0473, ybaR, b0484
Product description	YbaR^[2]; Cu⁺-exporting ATPase^[3] Copper-, silver-translocating P-type ATPase efflux pump; involved in copper resistance; copper- and silver-inducible; regulated by copper-responsive CueR activator^[4]
EC number (for enzymes)	3.6.3.4^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0031224	intrinsic to membrane	PMID:12351646^[5]	IDA: Inferred from Direct Assay		C	Seeded from Riley et al 2006 ^[1]. CopA was purified from everted membrane vesicles (Fig. 6).	complete
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	PMID:11167016^[6]	IDA: Inferred from Direct Assay		F	Figure 2	complete
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	PMID:12351646^[5]	IDA: Inferred from Direct Assay		F		complete
	GO:0006825	copper ion transport	PMID:10639134^[7]	IMP: Inferred from Mutant Phenotype		P	Everted membrane vesicles prepared from a ΔcopA strain that expressed copA from a plasmid accumulated ⁶⁴Cu. Accumulation required ATP.	complete
	GO:0043682	copper-transporting ATPase activity				F		Missing: evidence, reference
	GO:0016021	integral to membrane	PMID:11152613^[8]	ISM: Inferred from Sequence Model		C	Predicted transmembrane domains shown below in the table of Domains/Motifs/Modification sites.	Missing: with/from
	GO:0010273	detoxification of copper ion	PMID:10639134^[7]	IMP: Inferred from Mutant Phenotype		P	copA mutants are sensitive to copper ions.	complete
	GO:0016887	ATPase activity	PMID:12351646^[5]	IDA: Inferred from Direct Assay		F	Fig. 6 shows ATPase activity of CopA purified from membrane vesicles.	complete
	GO:0000166	nucleotide binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc (v14.0)	complete
	GO:0000287	magnesium ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0460	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004008	copper-exporting ATPase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006403	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005507	copper ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0186	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006403	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008250	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018303	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006754	ATP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006754	ATP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006754	ATP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006403	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006754	ATP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006416	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006754	ATP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008250	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006754	ATP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018303	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006825	copper ion transport	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0187	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000150	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005834	P	Seeded from EcoCyc (v14.0)	complete
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	F	Seeded from EcoCyc (v14.0)	complete
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	F	Seeded from EcoCyc (v14.0)	complete
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006416	F	Seeded from EcoCyc (v14.0)	complete
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018303	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006416	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9909	C	Seeded from EcoCyc (v14.0)	complete
	GO:0046872	metal ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006121	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046872	metal ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017969	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046872	metal ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	sdhA	PMID:16606699^[9]	Experiment(s):EBI-1136866
Protein	glpD	PMID:16606699^[9]	Experiment(s):EBI-1136866
Protein	ydcD	PMID:16606699^[9]	Experiment(s):EBI-1136866
Protein	dnaK	PMID:16606699^[9]	Experiment(s):EBI-1136866
Protein	groL	PMID:16606699^[9]	Experiment(s):EBI-1136866
Protein	hflB	PMID:16606699^[9]	Experiment(s):EBI-1136866
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source
plasma membrane	C-terminus localized in the cytoplasm with 8 predicted transmembrane domains	Daley et al. (2005) ^[10]
Inner Membrane		PMID:10639134^[7]	EchoLocation:copA
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VEQADVSITE AHVTGTASAE QLIETIKQAG YDASVSHPKA KPLAESSIPS EALTAVSEAL PAATADDDDS QQLLLSGMSC ASCVTRVQNA LQSVPGVTQA RVNLAERTAL VMGSASPQDL VQAVEKAGYG AEAIEDDAKR RERQQETAVA TMKRFRWQAI VALAVGIPVM VWGMIGDNMM VTADNRSLWL VIGLITLAVM VFAGGHFYRS AWKSLLNGAA TMDTLVALGT GVAWLYSMSV NLWPQWFPME ARHLYYEASA MIIGLINLGH MLEARARQRS SKALEKLLDL TPPTARLVTD EGEKSVPLAE VQPGMLLRLT TGDRVPVDGE ITQGEAWLDE AMLTGEPIPQ QKGEGDSVHA GTVVQDGSVL FRASAVGSHT TLSRIIRMVR QAQSSKPEIG QLADKISAVF VPVVVVIALV SAAIWYFFGP APQIVYTLVI ATTVLIIACP CALGLATPMS IISGVGRAAE FGVLVRDADA LQRASTLDTV VFDKTGTLTE GKPQVVAVKT FADVDEAQAL RLAAALEQGS SHPLARAILD KAGDMQLPQV NGFRTLRGLG VSGEAEGHAL LLGNQALLNE QQVGTKAIEA EITAQASQGA TPVLLAVDGK AVALLAVRDP LRSDSVAALQ RLHKAGYRLV MLTGDNPTTA NAIAKEAGID EVIAGVLPDG KAEAIKHLQS EGRQVAMVGD GINDAPALAQ ADVGIAMGGG SDVAIETAAI TLMRHSLMGV ADALAISRAT LHNMKQNLLG AFIYNSIGIP VAAGILWPFT GTLLNPVVAG AAMALSSITV VSNANRLLRF KPKE
Length	834
Mol. Wt	87.872 kDa
pI	5.4 (calculated)
Extinction coefficient	69,900 - 70,650 (calc based on 10 Y, 10 W, and 6 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:Q59385
Domain	6..62	PF00403 Heavy-metal-associated domain		PMID:19920124^[11]
Domain	102..160	PF00403 Heavy-metal-associated domain		PMID:19920124^[11]
Domain	517..732	PF00702 haloacid dehalogenase-like hydrolase		PMID:19920124^[11]
Domain	291..513	PF00122 E1-E2 ATPase		PMID:19920124^[11]
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=copA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
Purification protocol	PMID:12351646^[5]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128468	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946106	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0001681	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:Q59385	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6260	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13246	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946106	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002868	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3035	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 Fan, B & Rosen, BP (2002) Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase. J. Biol. Chem. 277 46987-92 PubMed
↑ Petersen, C & Møller, LB (2000) Control of copper homeostasis in Escherichia coli by a P-type ATPase, CopA, and a MerR-like transcriptional activator, CopR. Gene 261 289-98 PubMed
↑ ^7.0 ^7.1 ^7.2 Rensing, C et al. (2000) CopA: An Escherichia coli Cu(I)-translocating P-type ATPase. Proc. Natl. Acad. Sci. U.S.A. 97 652-6 PubMed
↑ Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
↑ ^11.0 ^11.1 ^11.2 ^11.3 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

copA:Gene Product(s): Difference between revisions

Latest revision as of 20:26, 17 February 2015

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

@@ Line 35: / Line 35: @@
 *
 ****************************************************************************************** -->{{Product_nomenclature_help}}
-{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" {{Prettytable}}
+{| {{Prettytable}}  id="R46aa32c577309"  class=" tableEdit Product_nomenclature_table"
 |-
@@ Line 44: / Line 44: @@
 !align=left {{table heading style}} |Synonyms
 ||
-copper transporter<ref name='LIB:Riley_2006'/>, B0484<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CopA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
+''copper transporter<ref name='LIB:Riley_2006'/>, B0484<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CopA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0478, JW0473, ybaR, b0484''
 |-
 !align=left {{table heading style}} |Product description
@@ Line 56: / Line 56: @@
 [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4]<ref name='LIB:Riley_2006'/>
-|-class='sortbottom'
+|- class="tableEdit_footer"
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+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.R46aa32c577309&page=20639&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table]</span> ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.R46aa32c577309-->
@@ Line 75: / Line 75: @@
 *
 ****************************************************************************************** -->{{Product_GO_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" {{Prettytable}}
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="G46aa32c670c12"  class=" tableEdit GO_table_product dataTable"
 |- {{table_heading_style}}
-!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
+!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
 |-
 |
 |
-GO:0005507
+GO:0031224
 |
-copper ion binding
+intrinsic to membrane
 |
-GO_REF:0000004
+PMID:12351646
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-SP_KW:KW-0186
 |
-F
+C
 |
-Seeded from EcoCyc
+Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
+CopA was purified from everted membrane vesicles (Fig. 6).
 |
 complete
@@ Line 101: / Line 103: @@
 |
-GO:0004008
+GO:0015662
 |
-copper-exporting ATPase activity
+ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
 |
-GO_REF:0000002<br />GO_REF:0000003
+PMID:11167016
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-InterPro:IPR006403<br />EC:3.6.3.4
 |
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Figure 2
 |
 complete
@@ Line 120: / Line 122: @@
 |
-GO:0005375
+GO:0015662
 |
-copper ion transmembrane transporter activity
+ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
 |
-GO_REF:0000004
+PMID:12351646
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-SP_KW:KW-0187
 |
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 |
 complete
@@ Line 139: / Line 141: @@
 |
-GO:0003824
+GO:0006825
 |
-catalytic activity
+copper ion transport
 |
-GO_REF:0000002
+PMID:10639134
 |
-IEA: Inferred from Electronic Annotation
+IMP: Inferred from Mutant Phenotype
 |
-InterPro:IPR005834
 |
-F
+P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Everted membrane vesicles prepared from a Δ''copA'' strain that expressed ''copA'' from a plasmid accumulated <sup>64</sup>Cu.  Accumulation required ATP.
 |
 complete
@@ Line 158: / Line 160: @@
 |
-GO:0000287
+GO:0043682
 |
-magnesium ion binding
+copper-transporting ATPase activity
 |
-GO_REF:0000004
 |
-IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0460
 |
 F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
 |
-complete
+Missing: evidence, reference
 |-
 |
 |
-GO:0000166
+GO:0016021
 |
-nucleotide binding
+integral to membrane
 |
-GO_REF:0000004
+PMID:11152613
 |
-IEA: Inferred from Electronic Annotation
+ISM: Inferred from Sequence Model
-|
-SP_KW:KW-0547
-|
-F
-|
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
-|
-complete
-|-
 |
-|
-GO:0016020
-|
-membrane
-|
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
-|
-IEA: Inferred from Electronic Annotation
-|
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR008250<br />SP_KW:KW-0472
 |
 C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Predicted transmembrane domains shown below in the table of Domains/Motifs/Modification sites.
 |
-complete
+Missing: with/from
 |-
 |
 |
-GO:0015992
+GO:0010273
 |
-proton transport
+detoxification of copper ion
 |
-GO_REF:0000002
+PMID:10639134
 |
-IEA: Inferred from Electronic Annotation
+IMP: Inferred from Mutant Phenotype
 |
-InterPro:IPR000695
 |
 P
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+''copA'' mutants are sensitive to copper ions.
 |
 complete
@@ Line 234: / Line 217: @@
 |
-GO:0005507
+GO:0016887
 |
-copper ion binding
+ATPase activity
 |
-GO_REF:0000004
+PMID:12351646
 |
-IEA: Inferred from Electronic Annotation
+IDA: Inferred from Direct Assay
 |
-SP_KW:KW-0186
 |
 F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Fig. 6 shows ATPase activity of CopA purified from membrane vesicles.
 |
 complete
@@ Line 253: / Line 236: @@
 |
-GO:0005524
+GO:0000166
 |
-ATP binding
+nucleotide binding
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR008250<br />SP_KW:KW-0067
+SP_KW:KW-0547
 |
 F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 272: / Line 255: @@
 |
-GO:0006810
+GO:0000287
 |
-transport
+magnesium ion binding
 |
-GO_REF:0000002<br />GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR001757<br />SP_KW:KW-0813
+SP_KW:KW-0460
 |
-P
+F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 291: / Line 274: @@
 |
-GO:0006811
+GO:0004008
 |
-ion transport
+copper-exporting ATPase activity
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0406
+InterPro:IPR006403
 |
-P
+F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 310: / Line 293: @@
 |
-GO:0006825
+GO:0005507
 |
-copper ion transport
+copper ion binding
 |
-GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0187
+SP_KW:KW-0186
 |
-P
+F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 329: / Line 312: @@
 |
-GO:0008152
+GO:0005524
 |
-metabolic process
+ATP binding
 |
-GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR005834
+InterPro:IPR000695
-|
-P
-|
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
-|
-complete
-|-
-|
-|
-GO:0015662
-|
-ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
-|
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
-|
-IEA: Inferred from Electronic Annotation
-|
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006416
 |
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 367: / Line 331: @@
 |
-GO:0016021
+GO:0005524
 |
-integral to membrane
+ATP binding
-|
-GO_REF:0000002<br />GO_REF:0000004
-|
-IEA: Inferred from Electronic Annotation
-|
-InterPro:IPR006416<br />SP_KW:KW-0812
-|
-C
-|
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
-|
-complete
-|-
-|
-|
-GO:0016787
-|
-hydrolase activity
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0378
+InterPro:IPR001757
 |
 F
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 405: / Line 350: @@
 |
-GO:0046873
+GO:0005524
 |
-metal ion transmembrane transporter activity
+ATP binding
 |
-GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
@@ Line 417: / Line 362: @@
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 424: / Line 369: @@
 |
-GO:0016820
+GO:0005524
 |
-hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
+ATP binding
 |
-GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
@@ Line 436: / Line 381: @@
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 443: / Line 388: @@
 |
-GO:0030001
+GO:0005524
 |
-metal ion transport
+ATP binding
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR006121<br />InterPro:IPR006403<br />InterPro:IPR006416
+InterPro:IPR018303
 |
-P
+F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 462: / Line 407: @@
 |
-GO:0046872
+GO:0005524
 |
-metal ion binding
+ATP binding
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR006121<br />InterPro:IPR006403<br />SP_KW:KW-0479
+SP_KW:KW-0067
 |
 F
 |
-Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
+Seeded from [[EcoCyc]] (v14.0)
-|
-complete
-|-
-|
-|
-GO:0031224
-|
-intrinsic to membrane
-|
-PMID:12351646
-|
-IDA: Inferred from Direct Assay
-|
-|
-C
-|
-Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
-CopA was purified from everted membrane vesicles (Fig. 6).
 |
 complete
@@ Line 506: / Line 430: @@
 plasma membrane
 |
-GO_REF:0000004<br />GO_REF:0000023
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-1003<br />SP_SL:SL-0039
+SP_KW:KW-1003
 |
 C
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 525: / Line 449: @@
 ATP biosynthetic process
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR006416<br />InterPro:IPR008250
+InterPro:IPR000695
 |
 P
 |
-Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 540: / Line 464: @@
 |
-GO:0000166
+GO:0006754
 |
-nucleotide binding
+ATP biosynthetic process
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0547
+InterPro:IPR001757
 |
-F
+P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 559: / Line 483: @@
 |
-GO:0000287
+GO:0006754
 |
-magnesium ion binding
+ATP biosynthetic process
-|
-GO_REF:0000004
-|
-IEA: Inferred from Electronic Annotation
-|
-SP_KW:KW-0460
-|
-F
-|
-Seeded from EcoCyc
-|
-complete
-|-
-|
-|
-GO:0003824
-|
-catalytic activity
-|
-GO_REF:0000002
-|
-IEA: Inferred from Electronic Annotation
-|
-InterPro:IPR005834
-|
-F
-|
-Seeded from EcoCyc
-|
-complete
-|-
-|
-|
-GO:0004008
-|
-copper-exporting ATPase activity
 |
-GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
@@ Line 607: / Line 493: @@
 InterPro:IPR006403
 |
-F
+P
-|
-Seeded from EcoCyc
-|
-complete
-|-
-|
-|
-GO:0005524
-|
-ATP binding
-|
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
-|
-IEA: Inferred from Electronic Annotation
-|
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR008250<br />SP_KW:KW-0067
-|
-F
-|
-Seeded from EcoCyc
-|
-complete
-|-
-|
-|
-GO:0005886
-|
-plasma membrane
-|
-GO_REF:0000004<br />GO_REF:0000023
-|
-IEA: Inferred from Electronic Annotation
-|
-SP_KW:KW-1003<br />SP_SL:SL-0039
-|
-C
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 658: / Line 506: @@
 ATP biosynthetic process
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR006416<br />InterPro:IPR008250
+InterPro:IPR006416
 |
 P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 673: / Line 521: @@
 |
-GO:0006810
+GO:0006754
 |
-transport
+ATP biosynthetic process
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0813
+InterPro:IPR008250
 |
 P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 692: / Line 540: @@
 |
-GO:0006811
+GO:0006754
 |
-ion transport
+ATP biosynthetic process
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0406
+InterPro:IPR018303
 |
 P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 715: / Line 563: @@
 copper ion transport
 |
-GO_REF:0000004<br />PMID:10639134
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
-IMP: Inferred from Mutant Phenotype
+IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0187<br />
+SP_KW:KW-0187
 |
 P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 734: / Line 582: @@
 metabolic process
 |
-GO_REF:0000002
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR005834
+InterPro:IPR000150
 |
 P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 749: / Line 597: @@
 |
-GO:0010273
+GO:0008152
 |
-detoxification of copper ion
+metabolic process
 |
-PMID:10639134
+GOA:interpro<br />GO_REF:0000002
 |
-IMP: Inferred from Mutant Phenotype
+IEA: Inferred from Electronic Annotation
 |
+InterPro:IPR005834
 |
 P
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 772: / Line 620: @@
 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />PMID:11167016<br />PMID:12351646
+GOA:interpro<br />GO_REF:0000002
 |
-IDA: Inferred from Direct Assay
+IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006416<br /><br />
+InterPro:IPR000695
 |
 F
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 787: / Line 635: @@
 |
-GO:0016020
+GO:0015662
 |
-membrane
+ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR000695<br />InterPro:IPR001757<br />InterPro:IPR006403<br />InterPro:IPR008250<br />SP_KW:KW-0472
+InterPro:IPR001757
 |
-C
+F
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 806: / Line 654: @@
 |
-GO:0016021
+GO:0015662
 |
-integral to membrane
+ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
 |
-GO_REF:0000002<br />GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR006416<br />SP_KW:KW-0812
+InterPro:IPR006416
 |
-C
+F
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 825: / Line 673: @@
 |
-GO:0016787
+GO:0015662
 |
-hydrolase activity
+ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
 |
-GO_REF:0000004
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-SP_KW:KW-0378
+InterPro:IPR018303
 |
 F
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 844: / Line 692: @@
 |
-GO:0016820
+GO:0016021
 |
-hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
+integral to membrane
 |
-GO_REF:0000002<br />GO_REF:0000003
+GOA:interpro<br />GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR008250<br />EC:3.6.3
+InterPro:IPR006416
 |
-F
+C
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 863: / Line 711: @@
 |
-GO:0030001
+GO:0016021
 |
-metal ion transport
+integral to membrane
 |
-GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
 |
-InterPro:IPR006121<br />InterPro:IPR006403<br />InterPro:IPR006416<br />InterPro:IPR017969
+SP_KW:KW-0812
 |
-P
+C
-|
-Seeded from EcoCyc
-|
-complete
-|-
-|
-|
-GO:0015662
-|
-ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
-|
-PMID:11167016
-|
-IDA: Inferred from Direct Assay
-|
-|
-F
-|
-Figure 2
-|
-complete
-|-
-|
-|
-GO:0015662
-|
-ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
-|
-PMID:12351646
-|
-IDA: Inferred from Direct Assay
-|
-|
-F
 |
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
-|-
-|
-|
-GO:0006825
-|
-copper ion transport
-|
-PMID:10639134
-|
-IMP: Inferred from Mutant Phenotype
-|
-|
-P
-|
-Everted membrane vesicles prepared from a Δ''copA'' strain that expressed ''copA'' from a plasmid accumulated <sup>64</sup>Cu.  Accumulation required ATP.
-|
-complete
-|-
-|
-|
-GO:0043682
-|
-copper-transporting ATPase activity
-|
-|
-|
-|
-F
-|
-|
-required field missing
 |-
 |
@@ Line 962: / Line 734: @@
 integral to membrane
 |
-PMID:11152613
+GO_REF:0000023
 |
-ISM: Inferred from Sequence Model
+IEA: Inferred from Electronic Annotation
 |
+SP_SL:SL-9909
 |
 C
 |
-Predicted transmembrane domains shown below in the table of Domains/Motifs/Modification sites.
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 977: / Line 749: @@
 |
-GO:0010273
+GO:0046872
 |
-detoxification of copper ion
+metal ion binding
 |
-PMID:10639134
+GOA:interpro<br />GO_REF:0000002
 |
-IMP: Inferred from Mutant Phenotype
+IEA: Inferred from Electronic Annotation
 |
+InterPro:IPR006121
 |
-P
+F
 |
-''copA'' mutants are sensitive to copper ions.
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 996: / Line 768: @@
 |
-GO:0016887
+GO:0046872
 |
-ATPase activity
+metal ion binding
 |
-PMID:12351646
+GOA:interpro<br />GO_REF:0000002
 |
-IDA: Inferred from Direct Assay
+IEA: Inferred from Electronic Annotation
 |
+InterPro:IPR017969
 |
 F
 |
-Fig. 6 shows ATPase activity of CopA purified from membrane vesicles.
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
@@ Line 1,015: / Line 787: @@
 |
-GO:0031224
+GO:0046872
 |
-intrinsic to membrane
+metal ion binding
 |
-PMID:12351646
+GOA:spkw<br />SP_KW:GO_REF:0000004
 |
-IDA: Inferred from Direct Assay
+IEA: Inferred from Electronic Annotation
 |
+SP_KW:KW-0479
 |
-C
+F
 |
-Seeded from EcoCyc
+Seeded from [[EcoCyc]] (v14.0)
 |
 complete
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.G46aa32c670c12&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.G46aa32c670c12&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</span> || || || || || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.G46aa32c670c12-->
@@ Line 1,044: / Line 816: @@
 *
 ****************************************************************************************** -->{{Product_interactions_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="V46aa32cce9c76"  class=" tableEdit Product_interactions_table dataTable"
 |- {{table heading style}}
 !|Partner Type!!Partner!!Notes!!References!!Evidence
@@ Line 1,114: / Line 886: @@
 Experiment(s):EBI-1136866<br />
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.V46aa32cce9c76&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.V46aa32cce9c76&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table]</span> || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.V46aa32cce9c76-->
@@ Line 1,131: / Line 903: @@
 *
 ****************************************************************************************** -->{{Product_localization_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="L46a7c43f303b5"  class=" tableEdit Product_localization_table"
 |- {{table heading style}}
-!|Compartment!!Description!!Evidence!!Notes
+!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
 |-
 |
@@ Line 1,141: / Line 913: @@
 |
 Daley et al. (2005) <ref name=PMID:15919996/>
+|
 |
+|-
+|
+Inner Membrane
+|
-|-class='sortbottom'
+|
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.L46a7c43f303b5&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || ||
+PMID:10639134
+|
+[http://www.york.ac.uk/res/thomas/Echolocation.cfm?EB_SubLocID=EB3035 EchoLocation:copA]
+|
+|- class="tableEdit_footer"
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.L46a7c43f303b5&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table]</span> || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.L46a7c43f303b5-->
@@ Line 1,165: / Line 950: @@
 *
 ****************************************************************************************** -->{{Product_physical_properties_help}}
-{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{|   id="X46aa32cea7bff"  class=" tableEdit Product_phys_prop_table"
+|-
+!align=left {{table heading style}} |Name
+||
 |-
@@ Line 1,192: / Line 981: @@
 !align=left {{table heading style}} |Mol. Wt
 ||
-.87 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
+.872 kDa
 |-
 !align=left {{table heading style}} |pI
 ||
+.4 (calculated)
 |-
 !align=left {{table heading style}} |Extinction coefficient
 ||
-- 70650 (calc based on 10 Y, 10 W, and 6 C residues)
+,900 - 70,650 (calc based on 10 Y, 10 W, and 6 C residues)
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.X46aa32cea7bff&page=20639&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.X46aa32cea7bff&page=20639&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table]</span> ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.X46aa32cea7bff-->
@@ Line 1,220: / Line 1,009: @@
 *
 ****************************************************************************************** -->{{Product_domains_motifs_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="M46aa32cf0cf93"  class=" tableEdit Product_motif_table dataTable"
 |- {{table heading style}}
-!|Type!!Residues!!Description!!Notes
+!|Type!!Residues!!Description!!Notes!!References
 |-
 |
-Domain
+Initiator Methionine
 |
-- 65
 |
-[[interpro:IPR006121|HMA 1]]
+Removed
 |
 [http://www.uniprot.org/uniprot/Q59385#section_features UniProt:Q59385]
-|-
 |
-Domain
-|
-- 163
-|
-[[interpro:IPR006121|HMA 2]]
-|
-[http://www.uniprot.org/uniprot/Q59385#section_features UniProt:Q59385]
 |-
 |
 Domain
 |
-- 824
+..62
 |
-Predicted membrane-spanning helix.
+[http://pfam.janelia.org/family/PF00403 PF00403  Heavy-metal-associated domain]
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
-|-
-|
-Domain
-|
-- 206
-|
-Predicted membrane-spanning helix.
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
+PMID:19920124
 |-
 |
 Domain
 |
-- 238
+..160
 |
-Predicted membrane-spanning helix.
+[http://pfam.janelia.org/family/PF00403 PF00403  Heavy-metal-associated domain]
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
-|-
-|
-Domain
-|
-- 267
-|
-Predicted membrane-spanning helix.
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
+PMID:19920124
 |-
 |
 Domain
 |
-- 299
+..732
 |
-Predicted membrane-spanning helix.
+[http://pfam.janelia.org/family/PF00702 PF00702  haloacid dehalogenase-like hydrolase]
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
-|-
-|
-Domain
 |
-- 458
+PMID:19920124
-|
-Predicted membrane-spanning helix.
-|
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
 |-
 |
 Domain
 |
-- 485
+..513
 |
-Predicted membrane-spanning helix.
+[http://pfam.janelia.org/family/PF00122 PF00122  E1-E2 ATPase]
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
-|-
-|
-Domain
-|
-- 797
-|
-Predicted membrane-spanning helix.
 |
-TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
+PMID:19920124
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.M46aa32cf0cf93&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.M46aa32cf0cf93&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.M46aa32cf0cf93-->
@@ Line 1,329: / Line 1,083: @@
 </table>
-<span id="Structure"></span><big>'''Structure'''</big>
+<table><tr valign='top'><td>
+<span id='Structure'></span><big>'''Structure'''</big><br />
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.X46a7c440c27bf-->
 <!--
@@ Line 1,337: / Line 1,092: @@
 *
 ****************************************************************************************** -->{{Product_structure_help}}
-{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{|   id="X46a7c440c27bf"  class=" tableEdit Product_structure_table"
 |-
 !align=left {{table heading style}} |Structures
 ||
-<beststructure>copA
+<beststructure>
-</beststructure>
+gene=copA
+taxon=562,83333
+</beststructure>
 |-
 !align=left {{table heading style}} |Models
 ||
 View models at:
-* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=copA&sub=keywordSearc EcoliPredict]
+* [http://www.proteinmodelportal.org/query/uniprot/Q59385 Protein Model Portal]
-* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=copA&organism=562&organismtext= ModBase]
+* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=Q59385 PSI-PRED (Q59385)]
-* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
+* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=Q59385 Genomes TO Protein (Q59385)] (GTOP)
-* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
-* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.X46a7c440c27bf&page=20639&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.X46a7c440c27bf&page=20639&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table]</span> ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.X46a7c440c27bf-->
-<!--Structure_notes--></protect>
+</td><td></protect>
+==== Structure figures ====
+<protect><!--          ***** PLEASE DO NOT EDIT BELOW THIS LINE *****         -->
+</td><tr><table><!--Structure_notes--></protect>
 ===Notes===
@@ Line 1,374: / Line 1,148: @@
 *
 ****************************************************************************************** -->{{Product_resources_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" {{Prettytable}}
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="W46aa32cfa235b"  class=" tableEdit Product_resource_table"
 |- {{table_heading_style}}
 !|Resource type!!Source!!Notes/Reference
@@ Line 1,385: / Line 1,159: @@
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.W46aa32cfa235b&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.W46aa32cfa235b&page=20639&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table]</span> || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.W46aa32cfa235b-->
@@ Line 1,403: / Line 1,177: @@
 *
 ****************************************************************************************** -->{{Gene_accessions_help}}
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="J46aa32cfecb2f"  class=" tableEdit Gene_accessions_table"
 |- {{table_heading_style}}
 !|Database!!Accession!!Notes
 |-
 |
-[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
+[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
+|
+[http://www.ncbi.nlm.nih.gov/protein/16128468 GI:16128468]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
 |
-[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6260-MONOMER EcoCyc:G6260-MONOMER]
+[http://www.ncbi.nlm.nih.gov/protein/NP_415017.1 GeneID:946106]
 |
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[[ASAP]]
+|
+ASAP:ABE-0001681
+|
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
+|-
+|
+[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
+|
+[http://www.uniprot.org/uniprot/Q59385 UniProtKB/Swiss-Prot:Q59385]
+|
+Escherichia coli str. K-12 substr. MG1655
 |-
 |
-[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
+[[EcoCyc]]
 |
-[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=Q59385 SwissModel:Q59385]
+EcoCyc:G6260
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
+[[EcoGene]]
 |
-[[uniprot:Q59385|UniProt:Q59385]]
+EcoGene:EG13246
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
+[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
 |
-[http://pfam.sanger.ac.uk/family?acc=PF00403 PFAM:PF00403]
+[http://www.ncbi.nlm.nih.gov/gene?term=946106 GeneID:946106]
 |
+Escherichia coli str. K-12 substr. MG1655
 |-
 |
-[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
+[[RegulonDB]]
 |
-[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415017 RefSeq:NP_415017]
+RegulonDB:ECK120002868
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
+[[EchoBASE]]
 |
-[http://salilab.org/modbase/searchbyid?databaseID=Q59385 ModBase:Q59385]
+EchoBASE:EB3035
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.J46aa32cfecb2f&page=20639&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.J46aa32cfecb2f&page=20639&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table]</span> || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.J46aa32cfecb2f-->
@@ Line 1,467: / Line 1,262: @@
 *
 ****************************************************************************************** -->
-{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="S46a7c444ea657"  class=" tableEdit Links_table"
 |- {{table_heading_style}}
 !|Name!!URL!!Comments
-|-class='sortbottom'
+|- class="tableEdit_footer"
-|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.S46a7c444ea657&page=20639&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
+|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20639.S46a7c444ea657&page=20639&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table]</span> || ||
 |}
 <!--box uid=421aa90e079fa326b6494f812ad13e79.20639.S46a7c444ea657-->
@@ Line 1,482: / Line 1,277: @@
 ==References==
 {{BacktoTop}}
+{{RefHelp}}
-<references/>
+<references />
 __NOTOC__
-</noinclude>
 ===Categories===
 {{BacktoTop}}
 [[Category:Proteins]]
-[[Category:GO:0016021_!_integral to membrane]][[Category:GO:0015662_!_ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism]]
+[[Category:RefGenome_Annotated_Gene]]
+[[Category:RefGenome_Annotated_Gene]]

copA:Gene Product(s): Difference between revisions

Latest revision as of 20:26, 17 February 2015

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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