htpG:Gene Product(s): Difference between revisions

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*  
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****************************************************************************************** -->{{Product_nomenclature_help}}
****************************************************************************************** -->{{Product_nomenclature_help}}
{| id="Z46aa321dbfef9"  class=" tableEdit Product_nomenclature_table"   
{|   id="Z46aa321dbfef9"  class=" tableEdit Product_nomenclature_table"   


|-
|-
!align=left |Standard name
!align=left {{table heading style}} |Standard name
||
||
HtpG  
HtpG  
|-
|-
!align=left |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
molecular chaperone HSP90 family<ref name='LIB:Riley_2006'/>, B0473<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HtpG<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, C62.5<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hsp90<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''molecular chaperone HSP90 family<ref name='LIB:Riley_2006'/>, B0473<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HtpG<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, C62.5<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hsp90<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0467, JW0462, b0473''
|-
|-
!align=left |Product description
!align=left {{table heading style}} |Product description
||
||
HtpG<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
HtpG<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Heat shock chaperone, HSP90 family; has ATPase activity; binds RpoH; rpoH regulon; dimeric<ref name='LIB:EcoGene'/>
Heat shock chaperone, HSP90 family; has ATPase activity; binds RpoH; rpoH regulon; dimeric<ref name='LIB:EcoGene'/>
|-
|-
!align=left |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
||
||


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****************************************************************************************** -->{{Product_GO_help}}
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{|   id="Y46aa321f28bf5"  class=" tableEdit GO_table_product dataTable"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="Y46aa321f28bf5"  class=" tableEdit GO_table_product dataTable"   
|-
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-  
|-  
|
|


|
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GO:0042623
GO:0000166
|
nucleotide binding
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
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|
ATPase activity, coupled
F
|
|
PMID:9707442
Seeded from [[EcoCyc]] (v14.0)
|
|
IDA: Inferred from Direct Assay
complete
|-
|
|


|
GO:0005524
|
ATP binding
|
GOA:hamap<br />GO_REF:0000020
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IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00505
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0006457
GO:0005524
|
ATP binding
|
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
|
InterPro:IPR001404
|
|
protein folding
F
|
|
PMID:10931286
Seeded from [[EcoCyc]] (v14.0)
|
|
NR
complete
|-
|
|


|
|
P
GO:0005524
|
ATP binding
|
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
|
InterPro:IPR003594
|
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0005515
GO:0005524
|
|
protein binding
ATP binding
|
|
PMID:15690043
GOA:interpro<br />GO_REF:0000002
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0A8T7
InterPro:IPR019805
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0005515
GO:0005524
|
|
protein binding
ATP binding
|
|
PMID:16606699
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0A6Y8
SP_KW:KW-0067
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0005515
GO:0005829
|
|
protein binding
cytosol
|
|
PMID:16606699
PMID:16858726
|
|
IPI: Inferred from Physical Interaction
IDA: Inferred from Direct Assay
|
|
UniProtKB:P36553
 
|
|
F
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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GO:0005515
GO:0005886
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protein binding
plasma membrane
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PMID:16606699
GOA:spkw<br />SP_KW:GO_REF:0000004
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IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
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UniProtKB:Q46808
SP_KW:KW-0997
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|
F
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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GO:0000166
GO:0005886
|
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nucleotide binding
plasma membrane
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GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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SP_KW:KW-0547
SP_KW:KW-1003
|
|
F
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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GO:0005524
GO:0006457
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|
ATP binding
protein folding
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GO_REF:0000002<br />GO_REF:0000004<br />GO_REF:0000020
GOA:hamap<br />GO_REF:0000020
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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InterPro:IPR003594<br />SP_KW:KW-0067<br />HAMAP:MF_00505
HAMAP:MF_00505
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|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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GO:0005737
GO:0006457
|
|
cytoplasm
protein folding
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GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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SP_KW:KW-0963
InterPro:IPR001404
|
|
C
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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protein folding
protein folding
|
|
GO_REF:0000002<br />GO_REF:0000020
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR019805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
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GO:0006950
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response to stress
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GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001404
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0006950
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response to stress
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GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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InterPro:IPR001404<br />HAMAP:MF_00505
InterPro:IPR019805
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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response to stress
response to stress
|
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GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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membrane
membrane
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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C
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0051082
GO:0019898
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|
unfolded protein binding
extrinsic to membrane
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GO_REF:0000002<br />GO_REF:0000020
GO_REF:0000023
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR001404<br />HAMAP:MF_00505
SP_SL:SL-9903
|
|
F
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
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GO:0006457
GO:0009408
|
|
protein folding
response to heat
|
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PMID:10931286
PMID:8349564
|
|
IEP: Inferred from Expression Pattern
|
|
 
|
|
P  
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
 
|
|
required fields missing 
complete
|-  
|-  
|
|


|
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GO:0005829
GO:0051082
|
|
cytosol
unfolded protein binding
|
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PMID:16858726
GOA:hamap<br />GO_REF:0000020
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
HAMAP:MF_00505
|
|
C
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0005886
GO:0051082
|
|
plasma membrane
unfolded protein binding
|
|
GO_REF:0000004<br />GO_REF:0000004<br />GO_REF:0000023
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0997<br />SP_KW:KW-1003<br />SP_SL:SL-0037
InterPro:IPR001404
|
|
C
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
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GO:0042623
GO:0051082
|
|
ATPase activity, coupled
unfolded protein binding
|
|
PMID:9707442
GOA:interpro<br />GO_REF:0000002
|
|
IDA
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR019805
|
|
F  
F
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
GO:0009408
GO:0006974
|
|
response to heat
response to DNA damage stimulus
|
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PMID:8349564
PMID:11967071
|
|
IEP: Inferred from Expression Pattern
IEP: Inferred from Expression Pattern
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*  
*  
****************************************************************************************** -->{{Product_interactions_help}}
****************************************************************************************** -->{{Product_interactions_help}}
{|   id="A46aa322796726"  class=" tableEdit Product_interactions_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="A46aa322796726"  class=" tableEdit Product_interactions_table dataTable"   
|-
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-  
|-  
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Experiment(s):EBI-1136800<br />  
Experiment(s):EBI-1136800<br />  
|-
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Protein
|
ugpB
|
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
hyfG
|
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
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Protein
|
mcrB
|
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
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Protein
|
yggR
|
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
ycbW
|
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
yeaI
|
|
PMID:19402753
|
LCMS(ID Probability):99.0


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*  
*  
****************************************************************************************** -->{{Product_localization_help}}
****************************************************************************************** -->{{Product_localization_help}}
{|   id="K46a7c398ef9f1"  class=" tableEdit Product_localization_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="K46a7c398ef9f1"  class=" tableEdit Product_localization_table"   
|-
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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****************************************************************************************** -->{{Product_physical_properties_help}}
{| id="K46aa3229ae1c5"  class=" tableEdit Product_phys_prop_table"   
{|   id="K46aa3229ae1c5"  class=" tableEdit Product_phys_prop_table"   
 
|-
!align=left {{table heading style}} |Name
||


|-
|-
!align=left |Sequence
!align=left {{table heading style}} |Sequence
||
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10461-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=EG10461-MONOMER at EcoCyc]  
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LLAERGTLED PNLFIRRMNQ LLVS</pre>  
LLAERGTLED PNLFIRRMNQ LLVS</pre>  
|-
|-
!align=left |Length
!align=left {{table heading style}} |Length
||
||
624
624
|-
|-
!align=left |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
71.424 kDa
71.424 kDa
|-
|-
!align=left |pI
!align=left {{table heading style}} |pI
||
||
5.0 (calculated)
5.0 (calculated)
|-
|-
!align=left |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
81,820 (calc based on 18 Y, 10 W, and C residues)
81,820 (calc based on 18 Y, 10 W, and 0 C residues)


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*  
*  
****************************************************************************************** -->{{Product_domains_motifs_help}}
****************************************************************************************** -->{{Product_domains_motifs_help}}
{|   id="I46aa322a137ed"  class=" tableEdit Product_motif_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="I46aa322a137ed"  class=" tableEdit Product_motif_table dataTable"   
|-
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-
|
Modification Site
|
409
|
phosphorylation site at S409
|
[[PHOSIDA#p-values|probability less than 75%]]
|
PMID:17938405
|-
|
Modification Site
|
410
|
phosphorylation site at S410
|
[[PHOSIDA#p-values|probability less than 75%]]
|
PMID:17938405
|-
|
Modification Site
|
405
|
phosphorylation site at T405
|
[[PHOSIDA#p-values|probability less than 75%]]
|
PMID:17938405
|-
|
Modification Site
|
104
|
phosphorylation site at S104
|
[[PHOSIDA#p-values|probability greater than 75%]]
|
PMID:17938405
|-
|
Modification Site
|
404
|
phosphorylation site at S404
|
[[PHOSIDA#p-values|probability less than 75%]]
|
PMID:17938405
|-
|
Domain
|
27..183
|
[http://pfam.janelia.org/family/PF02518 PF02518  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase]
|
 
|
PMID:19920124
|-
|
Domain
|
209..624
|
[http://pfam.janelia.org/family/PF00183 PF00183  Hsp90 protein]
|
 
|
PMID:19920124


|- class="tableEdit_footer"  
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|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20615.I46aa322a137ed&page=20615&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
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<!--box uid=421aa90e079fa326b6494f812ad13e79.20615.I46aa322a137ed--></td>
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****************************************************************************************** -->{{Product_structure_help}}
{| id="G46aa322a5d1b4"  class=" tableEdit Product_structure_table"   
{|   id="G46aa322a5d1b4"  class=" tableEdit Product_structure_table"   


|-
|-
!align=left |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>
<beststructure>
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</beststructure>
</beststructure>
|-
|-
!align=left |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0A6Z3 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0A6Z3 PSI-PRED (P0A6Z3)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0A6Z3 Genomes TO Protein (P0A6Z3)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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*  
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****************************************************************************************** -->{{Product_resources_help}}
****************************************************************************************** -->{{Product_resources_help}}
{|   id="X46aa322ee511c"  class=" tableEdit Product_resource_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="X46aa322ee511c"  class=" tableEdit Product_resource_table"   
|-
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference


Line 801: Line 1,022:
*  
*  
****************************************************************************************** -->{{Gene_accessions_help}}
****************************************************************************************** -->{{Gene_accessions_help}}
{|   id="M46aa322f3b769"  class=" tableEdit Gene_accessions_table"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="M46aa322f3b769"  class=" tableEdit Gene_accessions_table"   
|-
|- {{table_heading_style}}
!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-  
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10461-MONOMER EcoCyc:EG10461-MONOMER]
[http://www.ncbi.nlm.nih.gov/protein/16128457 GI:16128457]
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Escherichia coli str. K-12 substr. MG1655
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[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
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[http://www.ncbi.nlm.nih.gov/protein/NP_415006.1 GeneID:945099]
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Escherichia coli str. K-12 substr. MG1655
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[[ASAP]]
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ASAP:ABE-0001642
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.uniprot.org/uniprot/P0A6Z3 UniProtKB/Swiss-Prot:P0A6Z3]
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Escherichia coli str. K-12 substr. MG1655
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[[EcoCyc]]
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EcoCyc:EG10461
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[[EcoGene]]
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EcoGene:EG10461
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
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[[uniprot:P0A6Z3|UniProt:P0A6Z3]]
[http://www.ncbi.nlm.nih.gov/gene?term=945099 GeneID:945099]
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Escherichia coli str. K-12 substr. MG1655
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
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[http://pfam.sanger.ac.uk/family?acc=PF02518 PFAM:PF02518]
RegulonDB:ECK120000454
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415006 RefSeq:NP_415006]
EchoBASE:EB0456
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0006457_!_protein folding]][[Category:GO:0042623_!_ATPase activity, coupled]][[Category:Complex:molecular chaperone, HSP90 family]][[Category:Products with structures in PDB]]

Latest revision as of 20:26, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HtpG

Synonyms

molecular chaperone HSP90 family[1], B0473[2][1], HtpG[2][1], C62.5[2][1], Hsp90[2][1] , ECK0467, JW0462, b0473

Product description

HtpG[2][3];

Component of molecular chaperone, HSP90 family[3]

Heat shock chaperone, HSP90 family; has ATPase activity; binds RpoH; rpoH regulon; dimeric[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00505

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003594

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019805

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00505

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019805

P

Seeded from EcoCyc (v14.0)

complete

GO:0006950

response to stress

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404

P

Seeded from EcoCyc (v14.0)

complete

GO:0006950

response to stress

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019805

P

Seeded from EcoCyc (v14.0)

complete

GO:0006950

response to stress

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0019898

extrinsic to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9903

C

Seeded from EcoCyc (v14.0)

complete

GO:0009408

response to heat

PMID:8349564[6]

IEP: Inferred from Expression Pattern

P

complete

GO:0051082

unfolded protein binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00505

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019805

F

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

PMID:11967071[7]

IEP: Inferred from Expression Pattern

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of molecular chaperone, HSP90 family

could be indirect

Protein

rpoC

PMID:15690043[8]

Experiment(s):EBI-889372

Protein

hyfG

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

mcrB

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

pepB

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

rplB

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

rpmC

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

rpmG

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

rpsF

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

rpsG

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

ugpB

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

ycbW

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

yeaI

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

yggR

PMID:15690043[8]

Experiment(s):EBI-894374

Protein

hemF

PMID:16606699[9]

Experiment(s):EBI-1136800

Protein

ugpB

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

hyfG

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

mcrB

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

yggR

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

ycbW

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

yeaI

PMID:19402753[10]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKGQETRGFQ SEVKQLLHLM IHSLYSNKEI FLRELISNAS DAADKLRFRA LSNPDLYEGD
GELRVRVSFD KDKRTLTISD NGVGMTRDEV IDHLGTIAKS GTKSFLESLG SDQAKDSQLI
GQFGVGFYSA FIVADKVTVR TRAAGEKPEN GVFWESAGEG EYTVADITKE DRGTEITLHL
REGEDEFLDD WRVRSIISKY SDHIALPVEI EKREEKDGET VISWEKINKA QALWTRNKSE
ITDEEYKEFY KHIAHDFNDP LTWSHNRVEG KQEYTSLLYI PSQAPWDMWN RDHKHGLKLY
VQRVFIMDDA EQFMPNYLRF VRGLIDSSDL PLNVSREILQ DSTVTRNLRN ALTKRVLQML
EKLAKDDAEK YQTFWQQFGL VLKEGPAEDF ANQEAIAKLL RFASTHTDSS AQTVSLEDYV
SRMKEGQEKI YYITADSYAA AKSSPHLELL RKKGIEVLLL SDRIDEWMMN YLTEFDGKPF
QSVSKVDESL EKLADEVDES AKEAEKALTP FIDRVKALLG ERVKDVRLTH RLTDTPAIVS
TDADEMSTQM AKLFAAAGQK VPEVKYIFEL NPDHVLVKRA ADTEDEAKFS EWVELLLDQA
LLAERGTLED PNLFIRRMNQ LLVS
Length

624

Mol. Wt

71.424 kDa

pI

5.0 (calculated)

Extinction coefficient

81,820 (calc based on 18 Y, 10 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Modification Site

409

phosphorylation site at S409

probability less than 75%

PMID:17938405[11]

Modification Site

410

phosphorylation site at S410

probability less than 75%

PMID:17938405[11]

Modification Site

405

phosphorylation site at T405

probability less than 75%

PMID:17938405[11]

Modification Site

104

phosphorylation site at S104

probability greater than 75%

PMID:17938405[11]

Modification Site

404

phosphorylation site at S404

probability less than 75%

PMID:17938405[11]

Domain

27..183

PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

PMID:19920124[12]

Domain

209..624

PF00183 Hsp90 protein

PMID:19920124[12]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=htpG taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128457

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945099

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001642

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6Z3

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10461

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10461

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945099

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000454

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0456

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Chuang, SE & Blattner, FR (1993) Characterization of twenty-six new heat shock genes of Escherichia coli. J. Bacteriol. 175 5242-52 PubMed
  7. ↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  9. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  11. ↑ 11.0 11.1 11.2 11.3 11.4 Macek, B et al. (2008) Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol. Cell Proteomics 7 299-307 PubMed
  12. ↑ 12.0 12.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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