yniC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

YniC

Synonyms

predicted hydrolase[1], YniC[2][1], B1727[2][1] , ECK1725, JW1716, b1727

Product description

2-deoxyglucose-6-phosphatase[2][3]

2-deoxyglucose-6-P phosphatase; mutants are hypersensitive to 2-deoxyglucose; overproduction confers 2-deoxyglucose resistance; additional in vitro substrates: mannose-6-P phosphate, 2-deoxyribose-5-P, ribose-5-P, glucose-6-P; HAD1[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004346

glucose-6-phosphatase activity

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

Figure 1. Note that activity on glucose-6-P was lower than other substrates tested.

complete

GO:0050308

sugar-phosphatase activity

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

complete

GO:0003850

2-deoxyglucose-6-phosphatase activity

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

Figure 1.

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005834

F

Seeded from EcoCyc (v14.0)

complete

GO:0003850

2-deoxyglucose-6-phosphatase activity

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0004346

glucose-6-phosphatase activity

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005833

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005834

P

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016791

phosphatase activity

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

YniC had phosphatase activity on 11 of 80 phosphorylated compounds tested (listed in order of decreasing activity): 2-deoxy-glucose-6-P, erythrose-4-P, mannose-6-P, 3-phosphoglyceraldehyde, 2-dedoxyribose-5-P, glucose-6-P, ribose-5-P, glucosamine-6-P, fructose-6-P, fructose-1-P, and FMN.

complete

GO:0046872

metal ion binding

PMID:16990279[5]

IDA: Inferred from Direct Assay

F

Binds to Mg2+, Mn2+, Co2+, and Zn2+ (Suppl. Table 2). Km varies depending upon substrate present.

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

uidC

PMID:16606699[6]

Experiment(s):EBI-1140627

Protein

rplJ

PMID:16606699[6]

Experiment(s):EBI-1140627
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSTPRQILAA IFDMDGLLID SEPLWDRAEL DVMASLGVDI SRRNELPDTL GLRIDMVVDL
WYARQPWNGP SRQEVVERVI ARAISLVEET RPLLPGVREA VALCKEQGLL VGLASASPLH
MLEKVLTMFD LRDSFDALAS AEKLPYSKPH PQVYLDCAAK LGVDPLTCVA LEDSVNGMIA
SKAARMRSIV VPAPEAQNDP RFVLADVKLS SLTELTAKDL LG
Length

222

Mol. Wt

24.33 kDa

pI

4.7 (calculated)

Extinction coefficient

20,970 - 21,345 (calc based on 3 Y, 3 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

7..185

PF00702 haloacid dehalogenase-like hydrolase

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yniC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129681

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945632

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0005761

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P77247

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6932

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13988

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945632

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003520

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3744

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Kuznetsova, E et al. (2006) Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. J. Biol. Chem. 281 36149-61 PubMed
  6. ↑ 6.0 6.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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