yeeO:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

YeeO

Synonyms

predicted multidrug efflux system[1], B1985[2][1], YeeO[2][1] , ECK1980, JW1965, b1985

Product description

YeeO belongs to the MATE (multidrug and toxic compound extrusion) family of transporters[2][3]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0006855

drug transmembrane transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002528

P

Seeded from EcoCyc (v14.0)

complete

GO:0015238

drug transmembrane transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002528

F

Seeded from EcoCyc (v14.0)

complete

GO:0015297

antiporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002528

F

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002528

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0035442

dipeptide transmembrane transport

PMID:20067529[4]

IMP: Inferred from Mutant Phenotype

P

From EcoCyc (v21.0)

complete

GO:0005886

plasma membrane

PMID:15919996[5]

IDA: Inferred from Direct Assay

C

From EcoCyc (v21.0)

C-terminal fusions to alkaline phosphatase and green fluorescent protein.

complete

GO:0005887

integral component of plasma membrane

other:EcoCyc

IC: Inferred by Curator

C

Missing: with/from

GO:0035350

FAD transmembrane transport

PMID:25482085[6]

IDA: Inferred from Direct Assay

P

From EcoCyc (v21.0)

Assay of unpurified protein.

complete

GO:0044610

FMN transmembrane transporter activity

PMID:25482085[6]

IDA: Inferred from Direct Assay

F

From EcoCyc (v21.0)

Assay of unpurified protein

complete

GO:0015230

FAD transmembrane transporter activity

PMID:25482085[6]

IDA: Inferred from Direct Assay

F

From EcoCyc (v21.0)

Assay of unpurified protein

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 12 predicted transmembrane domains

Daley et al. (2005) [5]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLRHILTAKN LLSNPIFKFP NCLPFLSTVC CICRQFVGEN LCSFADSPSL FEMWFHFLQL
RSALNISSAL RQVVHGTRWH AKRKSYKVLF WREITPLAVP IFMENACVLL MGVLSTFLVS
WLGKDAMAGV GLADSFNMVI MAFFAAIDLG TTVVVAFSLG KRDRRRARVA TRQSLVIMTL
FAVLLATLIH HFGEQIIDFV AGDATTEVKA LALTYLELTV LSYPAAAITL IGSGALRGAG
NTKIPLLING SLNILNIIIS GILIYGLFSW PGLGFVGAGL GLTISRYIGA VAILWVLAIG
FNPALRISLK SYFKPLNFSI IWEVMGIGIP ASVESVLFTS GRLLTQMFVA GMGTSVIAGN
FIAFSIAALI NLPGSALGSA STIITGRRLG VGQIAQAEIQ LRHVFWLSTL GLTAIAWLTA
PFAGVMASFY TQDPQVKHVV VILIWLNALF MPIWSASWVL PAGFKGARDA RYAMWVSMLS
MWGCRVVVGY VLGIMLGWGV VGVWMGMFAD WAVRAVLFYW RMVTGRWLWK YPRPEPQKCE
KKPVVSE
Length

547

Mol. Wt

60.062 kDa

pI

10.3 (calculated)

Extinction coefficient

126,390 - 127,390 (calc based on 11 Y, 20 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

100..262

PF01554 MatE

PMID:19920124[7]

Domain

330..491

PF01554 MatE

PMID:19920124[7]

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<motif_map/>

tmhmm.php?gene=yeeO&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yeeO taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:226524727

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946506

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006586

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P76352

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7070

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13383

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946506

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003656

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3164

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Hayashi, M et al. (2010) Effect of multidrug-efflux transporter genes on dipeptide resistance and overproduction in Escherichia coli. FEMS Microbiol. Lett. 304 12-9 PubMed
  5. ↑ 5.0 5.1 Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  6. ↑ 6.0 6.1 6.2 McAnulty, MJ & Wood, TK (2014) YeeO from Escherichia coli exports flavins. Bioengineered 5 386-92 PubMed
  7. ↑ 7.0 7.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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