xapR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

XapR

Synonyms

DNA-binding transcriptional activator[1], B2405[2][1], YfeB[2][1], PndR[2][1], XapR[2][1] , ECK2399, JW2396, pRndR, yfeB, b2405

Product description

XapR transcriptional activator[2][3]

Regulatory gene for xapAB[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:2201776[5]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0A2Q4
UniProtKB:P05827
UniProtKB:P0A9F3

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:7559336[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:2201776[5]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0A2Q4
UniProtKB:P05827
UniProtKB:P0A9F3

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:7559336[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:2201776[5]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0A2Q4
UniProtKB:P05827
UniProtKB:P0A9F3

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:7559336[6]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ttdA

PMID:16606699[7]

Experiment(s):EBI-1142731

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1142731

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MERVYRTDLK LLRYFLAVAE ELHFGRAAAR LNMSQPPLSI HIKELENQLG TQLFIRHSRS
VVLTHAGKIL MEESRRLLVN ANNVLARIEQ IGRGEAGRIE LGVVGTAMWG RMRPVMRRFL
RENPNVDVLF REKMPAMQMA LLERRELDAG IWRMATEPPT GFTSLRLHES AFLVAMPEEH
HLSSFSTVPL EALRDEYFVT MPPVYTDWDF LQRVCQQVGF SPVVIREVNE PQTVLAMVSM
GIGITLIADS YAQMNWPGVI FRPLKQRIPA DLYIVYETQQ VTPAMVKLLA ALTQ
Length

294

Mol. Wt

33.627 kDa

pI

8.9 (calculated)

Extinction coefficient

32,430 - 32,555 (calc based on 7 Y, 4 W, and 1 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

92..294

PF03466 LysR substrate binding domain

PMID:19920124[8]

Domain

9..68

PF00126 Bacterial regulatory helix-turn-helix protein, lysR family

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=xapR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130331

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946862

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007922

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P23841

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11146

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11146

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946862

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001130

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1136

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 Brun, YV et al. (1990) Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. J. Mol. Biol. 214 825-43 PubMed
  6. 6.0 6.1 6.2 Seeger, C et al. (1995) Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli. J. Bacteriol. 177 5506-16 PubMed
  7. 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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