xapB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

XapB

Synonyms

xanthosine transporter[1], B2406[2][1], XapB[2][1] , ECK2400, JW2397, b2406

Product description

XapB xanthosine MFS transporter[2][3]

Xanthosine transporter[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0015553

xanthosine transmembrane transporter activity

PMID:7559336[5]

ISS: Inferred from Sequence or Structural Similarity

EcoliWiki:NupG

F

complete

GO:0005337

nucleoside transmembrane transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004740

F

Seeded from EcoCyc (v14.0)

complete

GO:0055086

nucleobase, nucleoside and nucleotide metabolic process

PMID:7559336[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0015858

nucleoside transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004740

P

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

PMID:7559336[5]

ISA: Inferred from Sequence Alignment

EcoliWiki:NupG

P

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0005337

nucleoside transmembrane transporter activity

PMID:7559336[5]

ISA: Inferred from Sequence Alignment

EcoliWiki:NupG

F

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004740

C

Seeded from EcoCyc (v14.0)

complete

GO:0015858

nucleoside transport

PMID:7559336[5]

ISA: Inferred from Sequence Alignment

EcoliWiki:NupG

P

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:7559336[5]

IDA: Inferred from Direct Assay

C

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

PMID:7559336[5]

ISS: Inferred from Sequence or Structural Similarity

EcoliWiki:NupG

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 12 predicted transmembrane domains

Daley et al. (2005) [6]

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSIAMRLKVM SFLQYFIWGS WLVTLGSYMI NTLHFTGANV GMVYSSKGIA AIIMPGIMGI
IADKWLRAER AYMLCHLVCA GVLFYAASVT DPDMMFWVML VNAMAFMPTI ALSNSVSYSC
LAQAGLDPVT AFPPIRVFGT VGFIVAMWAV SLLHLELSSL QLYIASGASL LLSAYALTLP
KIPVAEKKAT TSLASKLGLD AFVLFKNPRM AIFFLFAMML GAVLQITNVF GNPFLHDFAR
NPEFADSFVV KYPSILLSVS QMAEVGFILT IPFFLKRFGI KTVMLMSMVA WTLRFGFFAY
GDPSTTGFIL LLLSMIVYGC AFDFFNISGS VFVEQEVDSS IRASAQGLFM TMVNGVGAWV
GSILSGMAVD YFSVDGVKDW QTIWLVFAGY ALFLAVIFFF GFKYNHDPEK IKHRAVTH
Length

418

Mol. Wt

46.141 kDa

pI

8.5 (calculated)

Extinction coefficient

70,360 - 70,860 (calc based on 14 Y, 9 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..407

PF03825 Nucleoside H+ symporter

PMID:19920124[7]

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tmhmm.php?gene=xapB&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=xapB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130332

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946868

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007925

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P45562

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG13159

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13159

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946868

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002428

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2951

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Seeger, C et al. (1995) Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli. J. Bacteriol. 177 5506-16 PubMed
  6. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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