wzb:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Wzb

Synonyms

protein-tyrosine phosphatase[1], B2061[2][1], Wzb[2][1] , ECK2055, JW2046, b2061

Product description

G7106[2][3]

Phosphotyrosine-protein phosphatase Wzb; activates colanic acid synthesis for capsule production by dephosphorylating Wzc-P; mutants do not make capsules; induced by AI-2 pheromone[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000271

polysaccharide biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0270

P

Seeded from EcoCyc (v14.0)

complete

GO:0004721

phosphoprotein phosphatase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0904

F

Seeded from EcoCyc (v14.0)

complete

GO:0004725

protein tyrosine phosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000106

F

Seeded from EcoCyc (v14.0)

complete

GO:0004725

protein tyrosine phosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017867

F

Seeded from EcoCyc (v14.0)

complete

GO:0004725

protein tyrosine phosphatase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

F

Seeded from EcoCyc (v14.0)

complete

GO:0006470

protein amino acid dephosphorylation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000106

P

Seeded from EcoCyc (v14.0)

complete

GO:0006470

protein amino acid dephosphorylation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017867

P

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:10348860[5]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

degQ

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rplQ

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

folX

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rplN

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

yafO

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

ymfG

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rpsM

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

feoA

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rplB

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

lsrG

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

yraN

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rpmB

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rplS

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rpsI

PMID:16606699[6]

Experiment(s):EBI-1141802

Protein

rem

PMID:16606699[6]

Experiment(s):EBI-1141802
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MFNNILVVCV GNICRSPTAE RLLQRYHPEL KVESAGLGAL VGKGADPTAI SVAAEHQLSL
EGHCARQISR RLCRNYDLIL TMEKRHIERL CEMAPEMRGK VMLFGHWDNE CEIPDPYRKS
RETFAAVYTL LERSARQWAQ ALNAEQV
Length

147

Mol. Wt

16.708 kDa

pI

7.8 (calculated)

Extinction coefficient

16,960 - 17,710 (calc based on 4 Y, 2 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

3..141

PF01451 Low molecular weight phosphotyrosine protein phosphatase

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=wzb taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130001

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946564

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006822

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AAB2

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7106

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13567

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946564

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003692

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3337

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Vincent, C et al. (1999) Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb. J. Bacteriol. 181 3472-7 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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