waaA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

WaaA

Synonyms

3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase)[1], B3633[2][1], WaaA[2][1], KdtA[2][1] , ECK3623, JW3608, kdtA, b3633

Product description

3-deoxy-D-manno-octulosonate(Kdo)-lipid A transferase[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0005529

sugar binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007507

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9904

C

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007507

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

PMID:2651435[4]

IDA: Inferred from Direct Assay

F

complete

GO:0016020

membrane

PMID:2651435[4]

IDA: Inferred from Direct Assay

C

complete

GO:0009245

lipid A biosynthetic process

PMID:7499229[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0016740

transferase activity

PMID:1577828[6]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

entB

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplA

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplE

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplL

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplM

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplS

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplT

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplU

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rpmG

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rpsE

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

rpsJ

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

murE

PMID:15690043[7]

Experiment(s):EBI-883387

Protein

murE

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

tufB

PMID:19402753[8]

MALDI(Z-score):22.989507

Protein

tig

PMID:19402753[8]

MALDI(Z-score):38.502574

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLELLYTALL YLIQPLIWIR LWVRGRKAPA YRKRWGERYG FYRHPLKPGG IMLHSVSVGE
TLAAIPLVRA LRHRYPDLPI TVTTMTPTGS ERVQSAFGKD VQHVYLPYDL PDALNRFLNK
VDPKLVLIME TELWPNLIAA LHKRKIPLVI ANARLSARSA AGYAKLGKFV RRLLRRITLI
AAQNEEDGAR FVALGAKNNQ VTVTGSLKFD ISVTPQLAAK AVTLRRQWAP HRPVWIATST
HEGEESVVIA AHQALLQQFP NLLLILVPRH PERFPDAINL VRQAGLSYIT RSSGEVPSTS
TQVVVGDTMG ELMLLYGIAD LAFVGGSLVE RGGHNPLEAA AHAIPVLMGP HTFNFKDICA
RLEQASGLIT VTDATTLAKE VSSLLTDADY RSFYGRHAVE VLYQNQGALQ RLLQLLEPYL
PPKTH
Length

425

Mol. Wt

47.291 kDa

pI

10.2 (calculated)

Extinction coefficient

55,350 - 55,475 (calc based on 15 Y, 6 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

231..401

PF00534 Glycosyl transferases group 1

PMID:19920124[9]

Domain

31..213

PF04413 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)

PMID:19920124[9]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=waaA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131504

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949048

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011873

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AC75

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10520

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10520

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949048

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000513

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0515

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 Brozek, KA et al. (1989) Biosynthesis of lipopolysaccharide in Escherichia coli. Cytoplasmic enzymes that attach 3-deoxy-D-manno-octulosonic acid to lipid A. J. Biol. Chem. 264 6956-66 PubMed
  5. ↑ Belunis, CJ et al. (1995) Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli. J. Biol. Chem. 270 27646-52 PubMed
  6. ↑ Belunis, CJ & Raetz, CR (1992) Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. J. Biol. Chem. 267 9988-97 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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