ubiG:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

UbiG

Synonyms

bifunctional 3-demethylubiquinone-9 3-methyltransferase and 2-octaprenyl-6-hydroxy phenol methylase[1], B2232[2][1], PufX[2][1], YfaB[2][1], UbiG[2][1] , ECK2224, JW2226, pufX, yfaB, b2232

Product description

UbiG[2][3];

Component of 3-demethylubiquinone 3-methyltransferase[2]; bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase[3]

SAM:OMHMB methyltransferase; Reactions: 2-octaprenyl-6-hydroxylphenol to 2-octaprenyl-6-methoxyphenol; 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone to ubiquinone 8[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010233

F

Seeded from EcoCyc (v14.0)

complete

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00472

F

Seeded from EcoCyc (v14.0)

complete

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.1.1.64

F

Seeded from EcoCyc (v14.0)

complete

GO:0099119

3-demethylubiquinone-8 3-O-methyltransferase activity

PMID:10419476[5]

IDA: Inferred from Direct Assay

F

Imported from EcoCyc (v 23.5)

complete

GO:0006744

ubiquinone biosynthetic process

PMID:8703953[6]

IGI: Inferred from Genetic Interaction

P

imported from EcoCyc (v 23.5) complementation of coq3 mutant of Saccharomyces cerevisiae

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of 3-demethylubiquinone 3-methyltransferase

could be indirect

Protein

rpsA

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

phrB

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

dnaK

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

hemG

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

rplS

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

rpsM

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

glpD

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

hycF

PMID:16606699[7]

Experiment(s):EBI-1142262

Protein

rplV

PMID:15690043[8]

Experiment(s):EBI-890550
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MNAEKSPVNH NVDHEEIAKF EAVASRWWDL EGEFKPLHRI NPLRLGYIAE RAGGLFGKKV
LDVGCGGGIL AESMAREGAT VTGLDMGFEP LQVAKLHALE SGIQVDYVQE TVEEHAAKHA
GQYDVVTCME MLEHVPDPQS VVRACAQLVK PGGDVFFSTL NRNGKSWLMA VVGAEYILRM
VPKGTHDVKK FIKPAELLGW VDQTSLKERH ITGLHYNPIT NTFKLGPGVD VNYMLHTQNK
Length

240

Mol. Wt

26.554 kDa

pI

6.6 (calculated)

Extinction coefficient

30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

61..157

PF08241 Methyltransferase domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ubiG taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130167

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946607

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007374

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P17993

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11143

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11143

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946607

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001127

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1133

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Poon, WW et al. (1999) Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. J. Biol. Chem. 274 21665-72 PubMed
  6. ↑ Hsu, AY et al. (1996) Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis. Biochemistry 35 9797-806 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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