ubiF:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

UbiF

Synonyms

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase[1], B0662[2][1], YleB[2][1], UbiF[2][1] , ECK0654, JW0659, yleB, b0662

Product description

OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON[2][3]

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; produces 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol; required for ubiquinone synthesis; mutation confers resistance to bleomycin, phleomycin and heat[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0008682

2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity

PMID:10802164[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0004497

monooxygenase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002938

F

Seeded from EcoCyc (v14.0)

complete

GO:0004497

monooxygenase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0503

F

Seeded from EcoCyc (v14.0)

complete

GO:0006744

ubiquinone biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010971

P

Seeded from EcoCyc (v14.0)

complete

GO:0006744

ubiquinone biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0831

P

Seeded from EcoCyc (v14.0)

complete

GO:0016709

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010971

F

Seeded from EcoCyc (v14.0)

complete

GO:0050660

FAD binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010971

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002938

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010971

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ydaC

PMID:15690043[6]

Experiment(s):EBI-882246

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1137645

Protein

glpD

PMID:16606699[7]

Experiment(s):EBI-1137645

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1137645

Protein

ydaC

PMID:19402753[8]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTNQPTEIAI VGGGMVGGAL ALGLAQHGFA VTVIEHAEPA PFVADSQPDV RISAISAASV
SLLKGLGVWD AVQAMRCHPY RRLETWEWET AHVVFDAAEL KLPLLGYMVE NTVLQQALWQ
ALEAHPKVTL RVPGSLIALH RHDDLQELEL KGGEVIRAKL VIGADGANSQ VRQMAGIGVH
AWQYAQSCML ISVQCENDPG DSTWQQFTPD GPRAFLPLFD NWASLVWYDS PARIRQLQNM
NMAQLQAEIA KHFPSRLGYV TPLAAGAFPL TRRHALQYVQ PGLALVGDAA HTIHPLAGQG
VNLGYRDVDA LIDVLVNARS YGEAWASYPV LKRYQMRRMA DNFIMQSGMD LFYAGFSNNL
PPLRFMRNLG LMAAERAGVL KRQALKYALG L
Length

391

Mol. Wt

42.953 kDa

pI

7.1 (calculated)

Extinction coefficient

67,380 - 67,755 (calc based on 12 Y, 9 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

5..342

PF01494 FAD binding domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ubiF taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128645

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945261

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002265

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P75728

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6365

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13658

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945261

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002972

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3422

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Kwon, O et al. (2000) Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene. FEMS Microbiol. Lett. 186 157-61 PubMed
  6. ↑ Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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