trpD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TrpD

Synonyms

fused glutamine amidotransferase (component II) of anthranilate synthase[1], anthranilate phosphoribosyl transferase[1], B1263[2][1], TrpD[2][1], TrpGD[2][1] , ECK1257, JW1255, trpGD, b1263

Product description

anthranilate synthase component II[2][3];

Component of anthranilate synthase[2][3]

Tryptophan synthesis, bifunctional: anthranilate synthase component II and phosphoribosyl anthranilate transferase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000162

tryptophan biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00211

P

Seeded from EcoCyc (v14.0)

complete

GO:0000162

tryptophan biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005940

P

Seeded from EcoCyc (v14.0)

complete

GO:0000162

tryptophan biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0822

P

Seeded from EcoCyc (v14.0)

complete

GO:0004048

anthranilate phosphoribosyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00211

F

Seeded from EcoCyc (v14.0)

complete

GO:0004048

anthranilate phosphoribosyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005940

F

Seeded from EcoCyc (v14.0)

complete

GO:0004048

anthranilate phosphoribosyltransferase activity

PMID:4886290[5]

IDA: Inferred from Direct Assay

F

Fig. 9

complete

Contributes to

GO:0004049

anthranilate synthase activity

PMID:5331787[6]

IDA: Inferred from Direct Assay

F

Anthranilate synthase activity restored when extracts of trpD9778 and trpE5972 mutants are combined (Fig. 1).

complete

GO:0004049

anthranilate synthase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.3.27

F

Seeded from EcoCyc (v14.0)

complete

GO:0006541

glutamine metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001317

P

Seeded from EcoCyc (v14.0)

complete

GO:0006541

glutamine metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011702

P

Seeded from EcoCyc (v14.0)

complete

GO:0006541

glutamine metabolic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0315

P

Seeded from EcoCyc (v14.0)

complete

GO:0004049

anthranilate synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006221

F

Seeded from EcoCyc (v14.0)

complete

GO:0004048

anthranilate phosphoribosyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.4.2.18

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of anthranilate synthase

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Cytoplasm

PMID:4594441[7], PMID:6283099[8].

EchoLocation:trpD


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MADILLLDNI DSFTYNLADQ LRSNGHNVVI YRNHIPAQTL IERLATMSNP VLMLSPGPGV
PSEAGCMPEL LTRLRGKLPI IGICLGHQAI VEAYGGYVGQ AGEILHGKAS SIEHDGQAMF
AGLTNPLPVA RYHSLVGSNI PAGLTINAHF NGMVMAVRHD ADRVCGFQFH PESILTTQGA
RLLEQTLAWA QQKLEPANTL QPILEKLYQA QTLSQQESHQ LFSAVVRGEL KPEQLAAALV
SMKIRGEHPN EIAGAATALL ENAAPFPRPD YLFADIVGTG GDGSNSINIS TASAFVAAAC
GLKVAKHGNR SVSSKSGSSD LLAAFGINLD MNADKSRQAL DELGVCFLFA PKYHTGFRHA
MPVRQQLKTR TLFNVLGPLI NPAHPPLALI GVYSPELVLP IAETLRVLGY QRAAVVHSGG
MDEVSLHAPT IVAELHDGEI KSYQLTAEDF GLTPYHQEQL AGGTPEENRD ILTRLLQGKG
DAAHEAAVAA NVAMLMRLHG HEDLQANAQT VLEVLRSGSA YDRVTALAAR G
Length

531

Mol. Wt

56.87 kDa

pI

6.5 (calculated)

Extinction coefficient

24,870 - 25,495 (calc based on 13 Y, 1 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P00904

Domain

5..190

PF00117 Glutamine amidotransferase class-I

PMID:19920124[9]

Domain

199..264

PF02885 Glycosyl transferase family, helical bundle domain

PMID:19920124[9]

Domain

270..521

PF00591 Glycosyl transferase family, a/b domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=trpD taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129224

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945109

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004241

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P00904

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11027

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11027

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945109

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001016

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1020

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Ito, J & Yanofsky, C (1969) Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits. J. Bacteriol. 97 734-42 PubMed
  6. ↑ Ito, J & Yanofsky, C (1966) The nature of the anthranilic acid synthetase complex of Escherichia coli. J. Biol. Chem. 241 4112-4 PubMed
  7. ↑ Li, SL et al. (1974) Structural homology of the glutamine amidotransferase subunits of the anthranilate synthetases of Escherichia coli, Salmonella typhimurium and Serratia marcescens. Nature 248 48-50 PubMed
  8. ↑ Horowitz, H et al. (1982) Nucleotide sequence of the trpD gene, encoding anthranilate synthetase component II of Escherichia coli. J. Mol. Biol. 156 245-56 PubMed
  9. ↑ 9.0 9.1 9.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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